DNA methylation of shelf, shore and open sea CpG positions distinguish high microsatellite instability from low or stable microsatellite status colon cancer stem cells
To investigate the genome-wide methylation of genetically characterized colorectal cancer stem cell (CR-CSC) lines. Eight CR-CSC lines were isolated from primary colorectal cancer (CRC) tissues, cultured and characterized for aneuploidy, mutational status of CRC-related genes and microsatellite inst...
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| Veröffentlicht in: | Epigenomics 2019-05, Vol.11 (6), p.587-604 |
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| creator | Visone, Rosa Bacalini, Maria Giulia Di Franco, Simone Ferracin, Manuela Colorito, Maria Luisa Pagotto, Sara Laprovitera, Noemi Licastro, Danilo Di Marco, Mirco Scavo, Emanuela Bassi, Cristian Saccenti, Elena Nicotra, Annalisa Grzes, Maria Garagnani, Paolo De Laurenzi, Vincenzo Valeri, Nicola Mariani-Costantini, Renato Negrini, Massimo Stassi, Giorgio Veronese, Angelo |
| description | To investigate the genome-wide methylation of genetically characterized colorectal cancer stem cell (CR-CSC) lines.
Eight CR-CSC lines were isolated from primary colorectal cancer (CRC) tissues, cultured and characterized for aneuploidy, mutational status of CRC-related genes and microsatellite instability (MSI). Genome-wide DNA methylation was assessed by MethylationEPIC microarray.
We describe a distinctive methylation pattern that is maintained following
passages in immune-compromised mice. We identified an epigenetic CR-CSC signature associated with MSI. We noticed that the preponderance of the differentially methylated positions do not reside at CpG islands, but spread to shelf and open sea regions.
Given that CRCs with MSI-high status have a lower metastatic potential, the identification of a MSI-related methylation signature could provide new insights and possible targets into metastatic CRC. |
| doi_str_mv | 10.2217/epi-2018-0153 |
| format | Article |
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Eight CR-CSC lines were isolated from primary colorectal cancer (CRC) tissues, cultured and characterized for aneuploidy, mutational status of CRC-related genes and microsatellite instability (MSI). Genome-wide DNA methylation was assessed by MethylationEPIC microarray.
We describe a distinctive methylation pattern that is maintained following
passages in immune-compromised mice. We identified an epigenetic CR-CSC signature associated with MSI. We noticed that the preponderance of the differentially methylated positions do not reside at CpG islands, but spread to shelf and open sea regions.
Given that CRCs with MSI-high status have a lower metastatic potential, the identification of a MSI-related methylation signature could provide new insights and possible targets into metastatic CRC.</description><identifier>ISSN: 1750-1911</identifier><identifier>EISSN: 1750-192X</identifier><identifier>DOI: 10.2217/epi-2018-0153</identifier><identifier>PMID: 31066579</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Aneuploidy ; Animals ; Cancer ; Colon ; Colon cancer ; colon cancer stem cells ; Colonic Neoplasms - genetics ; Colonic Neoplasms - pathology ; Colorectal cancer ; Colorectal carcinoma ; CpG islands ; CpG Islands - genetics ; Deoxyribonucleic acid ; DNA ; DNA Methylation ; DNA microarrays ; Drug Resistance, Neoplasm - genetics ; Epigenesis, Genetic ; Epigenetics ; Genes ; Genomes ; Heterografts ; Humans ; Kinases ; Metastases ; Mice ; Microsatellite Instability ; MSI ; MSS ; Neoplastic Stem Cells - pathology ; Stability ; Stability analysis ; Stem cell transplantation ; Stem cells ; Tumors</subject><ispartof>Epigenomics, 2019-05, Vol.11 (6), p.587-604</ispartof><rights>2019 Angelo Veronese</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-e923e7e2be3792f04b1b725b25592a362d8a411927f944233c1ee977074925f13</citedby><cites>FETCH-LOGICAL-c410t-e923e7e2be3792f04b1b725b25592a362d8a411927f944233c1ee977074925f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2275990741/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2275990741?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,27923,27924,33529,33530,43658,64384,64386,64388,72340,73975</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31066579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Visone, Rosa</creatorcontrib><creatorcontrib>Bacalini, Maria Giulia</creatorcontrib><creatorcontrib>Di Franco, Simone</creatorcontrib><creatorcontrib>Ferracin, Manuela</creatorcontrib><creatorcontrib>Colorito, Maria Luisa</creatorcontrib><creatorcontrib>Pagotto, Sara</creatorcontrib><creatorcontrib>Laprovitera, Noemi</creatorcontrib><creatorcontrib>Licastro, Danilo</creatorcontrib><creatorcontrib>Di Marco, Mirco</creatorcontrib><creatorcontrib>Scavo, Emanuela</creatorcontrib><creatorcontrib>Bassi, Cristian</creatorcontrib><creatorcontrib>Saccenti, Elena</creatorcontrib><creatorcontrib>Nicotra, Annalisa</creatorcontrib><creatorcontrib>Grzes, Maria</creatorcontrib><creatorcontrib>Garagnani, Paolo</creatorcontrib><creatorcontrib>De Laurenzi, Vincenzo</creatorcontrib><creatorcontrib>Valeri, Nicola</creatorcontrib><creatorcontrib>Mariani-Costantini, Renato</creatorcontrib><creatorcontrib>Negrini, Massimo</creatorcontrib><creatorcontrib>Stassi, Giorgio</creatorcontrib><creatorcontrib>Veronese, Angelo</creatorcontrib><title>DNA methylation of shelf, shore and open sea CpG positions distinguish high microsatellite instability from low or stable microsatellite status colon cancer stem cells</title><title>Epigenomics</title><addtitle>Epigenomics</addtitle><description>To investigate the genome-wide methylation of genetically characterized colorectal cancer stem cell (CR-CSC) lines.
Eight CR-CSC lines were isolated from primary colorectal cancer (CRC) tissues, cultured and characterized for aneuploidy, mutational status of CRC-related genes and microsatellite instability (MSI). Genome-wide DNA methylation was assessed by MethylationEPIC microarray.
We describe a distinctive methylation pattern that is maintained following
passages in immune-compromised mice. We identified an epigenetic CR-CSC signature associated with MSI. We noticed that the preponderance of the differentially methylated positions do not reside at CpG islands, but spread to shelf and open sea regions.
Given that CRCs with MSI-high status have a lower metastatic potential, the identification of a MSI-related methylation signature could provide new insights and possible targets into metastatic CRC.</description><subject>Aneuploidy</subject><subject>Animals</subject><subject>Cancer</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>colon cancer stem cells</subject><subject>Colonic Neoplasms - genetics</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>CpG islands</subject><subject>CpG Islands - genetics</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Methylation</subject><subject>DNA microarrays</subject><subject>Drug Resistance, Neoplasm - genetics</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Genes</subject><subject>Genomes</subject><subject>Heterografts</subject><subject>Humans</subject><subject>Kinases</subject><subject>Metastases</subject><subject>Mice</subject><subject>Microsatellite Instability</subject><subject>MSI</subject><subject>MSS</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>Stability</subject><subject>Stability analysis</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Tumors</subject><issn>1750-1911</issn><issn>1750-192X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU9rFTEUxQdRbGm7dCsBNy4cmz-TyWRZnlqFopsW3IVM3k0nZSYZkwzyPpFf04RXuyiYzb25_HI4uadp3hD8kVIiLmF1LcVkaDHh7EVzSgTHLZH058unnpCT5iKlB1wOo4PsyevmhBHc91zI0-bPp-9XaIE8HWadXfAoWJQmmO2HUkIEpP0ehRU8SqDRbr1Ga0iukgntXcrO328uTWhy9xNanIkh6Qzz7DIg51PWoyv9AdkYFjSH3yhEVKczPKfLNG8JmTAXF0Z7A5WEBZkCpPPmldVzgovHetbcffl8u_va3vy4_ra7umlNR3BuQVIGAugITEhqcTeSUVA-Us4l1ayn-0F3pGxIWNl1lDFDAKQQWHSSckvYWfP-qLvG8GuDlNXiUnWgPYQtKUoZGbqh57yg756hD2GLvrgrlOBSFtEq2B6p-tkUwao1ukXHgyJY1RBVCVHVEFUNsfBvH1W3cYH9E_0vsgLII2C3vEVIxkHZlTreygtnnIf_iP8Fig2s7Q</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Visone, Rosa</creator><creator>Bacalini, Maria Giulia</creator><creator>Di Franco, Simone</creator><creator>Ferracin, Manuela</creator><creator>Colorito, Maria Luisa</creator><creator>Pagotto, Sara</creator><creator>Laprovitera, Noemi</creator><creator>Licastro, Danilo</creator><creator>Di Marco, Mirco</creator><creator>Scavo, Emanuela</creator><creator>Bassi, Cristian</creator><creator>Saccenti, Elena</creator><creator>Nicotra, Annalisa</creator><creator>Grzes, Maria</creator><creator>Garagnani, Paolo</creator><creator>De Laurenzi, Vincenzo</creator><creator>Valeri, Nicola</creator><creator>Mariani-Costantini, Renato</creator><creator>Negrini, Massimo</creator><creator>Stassi, Giorgio</creator><creator>Veronese, Angelo</creator><general>Future Medicine Ltd</general><scope>FUMOA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190501</creationdate><title>DNA methylation of shelf, shore and open sea CpG positions distinguish high microsatellite instability from low or stable microsatellite status colon cancer stem cells</title><author>Visone, Rosa ; Bacalini, Maria Giulia ; Di Franco, Simone ; Ferracin, Manuela ; Colorito, Maria Luisa ; Pagotto, Sara ; Laprovitera, Noemi ; Licastro, Danilo ; Di Marco, Mirco ; Scavo, Emanuela ; Bassi, Cristian ; Saccenti, Elena ; Nicotra, Annalisa ; Grzes, Maria ; Garagnani, Paolo ; De Laurenzi, Vincenzo ; Valeri, Nicola ; Mariani-Costantini, Renato ; Negrini, Massimo ; Stassi, Giorgio ; Veronese, Angelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-e923e7e2be3792f04b1b725b25592a362d8a411927f944233c1ee977074925f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aneuploidy</topic><topic>Animals</topic><topic>Cancer</topic><topic>Colon</topic><topic>Colon cancer</topic><topic>colon cancer stem cells</topic><topic>Colonic Neoplasms - genetics</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>CpG islands</topic><topic>CpG Islands - genetics</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Methylation</topic><topic>DNA microarrays</topic><topic>Drug Resistance, Neoplasm - genetics</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Genes</topic><topic>Genomes</topic><topic>Heterografts</topic><topic>Humans</topic><topic>Kinases</topic><topic>Metastases</topic><topic>Mice</topic><topic>Microsatellite Instability</topic><topic>MSI</topic><topic>MSS</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>Stability</topic><topic>Stability analysis</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Visone, Rosa</creatorcontrib><creatorcontrib>Bacalini, Maria Giulia</creatorcontrib><creatorcontrib>Di Franco, Simone</creatorcontrib><creatorcontrib>Ferracin, Manuela</creatorcontrib><creatorcontrib>Colorito, Maria Luisa</creatorcontrib><creatorcontrib>Pagotto, Sara</creatorcontrib><creatorcontrib>Laprovitera, Noemi</creatorcontrib><creatorcontrib>Licastro, Danilo</creatorcontrib><creatorcontrib>Di Marco, Mirco</creatorcontrib><creatorcontrib>Scavo, Emanuela</creatorcontrib><creatorcontrib>Bassi, Cristian</creatorcontrib><creatorcontrib>Saccenti, Elena</creatorcontrib><creatorcontrib>Nicotra, Annalisa</creatorcontrib><creatorcontrib>Grzes, Maria</creatorcontrib><creatorcontrib>Garagnani, Paolo</creatorcontrib><creatorcontrib>De Laurenzi, Vincenzo</creatorcontrib><creatorcontrib>Valeri, Nicola</creatorcontrib><creatorcontrib>Mariani-Costantini, Renato</creatorcontrib><creatorcontrib>Negrini, Massimo</creatorcontrib><creatorcontrib>Stassi, Giorgio</creatorcontrib><creatorcontrib>Veronese, Angelo</creatorcontrib><collection>Future Medicine (Open Access)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Epigenomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Visone, Rosa</au><au>Bacalini, Maria Giulia</au><au>Di Franco, Simone</au><au>Ferracin, Manuela</au><au>Colorito, Maria Luisa</au><au>Pagotto, Sara</au><au>Laprovitera, Noemi</au><au>Licastro, Danilo</au><au>Di Marco, Mirco</au><au>Scavo, Emanuela</au><au>Bassi, Cristian</au><au>Saccenti, Elena</au><au>Nicotra, Annalisa</au><au>Grzes, Maria</au><au>Garagnani, Paolo</au><au>De Laurenzi, Vincenzo</au><au>Valeri, Nicola</au><au>Mariani-Costantini, Renato</au><au>Negrini, Massimo</au><au>Stassi, Giorgio</au><au>Veronese, Angelo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA methylation of shelf, shore and open sea CpG positions distinguish high microsatellite instability from low or stable microsatellite status colon cancer stem cells</atitle><jtitle>Epigenomics</jtitle><addtitle>Epigenomics</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>11</volume><issue>6</issue><spage>587</spage><epage>604</epage><pages>587-604</pages><issn>1750-1911</issn><eissn>1750-192X</eissn><abstract>To investigate the genome-wide methylation of genetically characterized colorectal cancer stem cell (CR-CSC) lines.
Eight CR-CSC lines were isolated from primary colorectal cancer (CRC) tissues, cultured and characterized for aneuploidy, mutational status of CRC-related genes and microsatellite instability (MSI). Genome-wide DNA methylation was assessed by MethylationEPIC microarray.
We describe a distinctive methylation pattern that is maintained following
passages in immune-compromised mice. We identified an epigenetic CR-CSC signature associated with MSI. We noticed that the preponderance of the differentially methylated positions do not reside at CpG islands, but spread to shelf and open sea regions.
Given that CRCs with MSI-high status have a lower metastatic potential, the identification of a MSI-related methylation signature could provide new insights and possible targets into metastatic CRC.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>31066579</pmid><doi>10.2217/epi-2018-0153</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Epigenomics, 2019-05, Vol.11 (6), p.587-604 |
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| source | MEDLINE; ProQuest Central (Alumni Edition); ProQuest Central UK/Ireland; PubMed Central |
| subjects | Aneuploidy Animals Cancer Colon Colon cancer colon cancer stem cells Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal cancer Colorectal carcinoma CpG islands CpG Islands - genetics Deoxyribonucleic acid DNA DNA Methylation DNA microarrays Drug Resistance, Neoplasm - genetics Epigenesis, Genetic Epigenetics Genes Genomes Heterografts Humans Kinases Metastases Mice Microsatellite Instability MSI MSS Neoplastic Stem Cells - pathology Stability Stability analysis Stem cell transplantation Stem cells Tumors |
| title | DNA methylation of shelf, shore and open sea CpG positions distinguish high microsatellite instability from low or stable microsatellite status colon cancer stem cells |
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