Anti-NMDA receptor antibody positivity in acute psychotic states: An exploratory study
The glutamatergic theory of schizophrenia postulates N-methyl-D-aspartate receptor (NMDA-R) dysfunction. Anti-NMDA receptor antibodies may be present in some patients with psychosis. Fifteen patients presenting with acute psychotic states having one additional clinical feature suggestive of autoimmu...
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| Veröffentlicht in: | Asian journal of psychiatry 2019-06, Vol.43, p.95-98 |
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| creator | Bharadwaj, Balaji Sathyanarayanan, Gopinath Kaliaperumal, Venkatesh Dhodapkar, Rahul |
| description | The glutamatergic theory of schizophrenia postulates N-methyl-D-aspartate receptor (NMDA-R) dysfunction. Anti-NMDA receptor antibodies may be present in some patients with psychosis. Fifteen patients presenting with acute psychotic states having one additional clinical feature suggestive of autoimmune etiology were recruited. Serum antibodies against NMDA-receptor were tested at baseline and at follow-up using Indirect Immunofluorescence Technique. None of the 15 patients had positive anti-NMDA antibody at baseline or at follow-up. The study failed to detect anti-NMDA antibodies in patients with acute psychotic states with clinical suspicion of autoimmunity. This does not rule out other mechanisms of NMDA receptor dysfunction in these patients. The glutamatergic theory of schizophrenia postulates N-methyl-D-aspartate receptor (NMDA-R) dysfunction. Anti-NMDA receptor antibodies may be present in some patients with psychosis. Fifteen patients presenting with acute psychotic states having one additional clinical feature suggestive of autoimmune etiology were recruited. Serum antibodies against NMDA-receptor were tested at baseline and at follow-up using Indirect Immunofluorescence Technique. None of the 15 patients had positive anti-NMDA antibody at baseline or at follow-up. The study failed to detect anti-NMDA antibodies in patients with acute psychotic states with clinical suspicion of autoimmunity. This does not rule out other mechanisms of NMDA receptor dysfunction in these patients.
•Patients with acute psychosis and features of possible autoimmune etiology were taken.•The serology was negative at baseline and at follow-up after a period of few weeks.•The study does not rule out other possible causes of NMDA-receptor dysfunction. |
| doi_str_mv | 10.1016/j.ajp.2019.05.023 |
| format | Article |
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•Patients with acute psychosis and features of possible autoimmune etiology were taken.•The serology was negative at baseline and at follow-up after a period of few weeks.•The study does not rule out other possible causes of NMDA-receptor dysfunction.</description><identifier>ISSN: 1876-2018</identifier><identifier>EISSN: 1876-2026</identifier><identifier>DOI: 10.1016/j.ajp.2019.05.023</identifier><identifier>PMID: 31121536</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acute Disease ; acute psychosis ; Adolescent ; Autoantibodies - blood ; autoimmunity ; Female ; Fluorescent Antibody Technique, Indirect ; Follow-Up Studies ; Humans ; Male ; N-methyl-D-aspartate receptors ; NR1 NMDA receptor ; Psychotic disorders ; Psychotic Disorders - blood ; Psychotic Disorders - immunology ; Psychotic Disorders - physiopathology ; Receptors, N-Methyl-D-Aspartate - immunology ; Young Adult</subject><ispartof>Asian journal of psychiatry, 2019-06, Vol.43, p.95-98</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-1e00a930741edf224e0dd7c95f5d40006fe52a6e7710c0f47482351d1eb2d8333</citedby><cites>FETCH-LOGICAL-c353t-1e00a930741edf224e0dd7c95f5d40006fe52a6e7710c0f47482351d1eb2d8333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1876201818311602$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31121536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bharadwaj, Balaji</creatorcontrib><creatorcontrib>Sathyanarayanan, Gopinath</creatorcontrib><creatorcontrib>Kaliaperumal, Venkatesh</creatorcontrib><creatorcontrib>Dhodapkar, Rahul</creatorcontrib><title>Anti-NMDA receptor antibody positivity in acute psychotic states: An exploratory study</title><title>Asian journal of psychiatry</title><addtitle>Asian J Psychiatr</addtitle><description>The glutamatergic theory of schizophrenia postulates N-methyl-D-aspartate receptor (NMDA-R) dysfunction. Anti-NMDA receptor antibodies may be present in some patients with psychosis. Fifteen patients presenting with acute psychotic states having one additional clinical feature suggestive of autoimmune etiology were recruited. Serum antibodies against NMDA-receptor were tested at baseline and at follow-up using Indirect Immunofluorescence Technique. None of the 15 patients had positive anti-NMDA antibody at baseline or at follow-up. The study failed to detect anti-NMDA antibodies in patients with acute psychotic states with clinical suspicion of autoimmunity. This does not rule out other mechanisms of NMDA receptor dysfunction in these patients. The glutamatergic theory of schizophrenia postulates N-methyl-D-aspartate receptor (NMDA-R) dysfunction. Anti-NMDA receptor antibodies may be present in some patients with psychosis. Fifteen patients presenting with acute psychotic states having one additional clinical feature suggestive of autoimmune etiology were recruited. Serum antibodies against NMDA-receptor were tested at baseline and at follow-up using Indirect Immunofluorescence Technique. None of the 15 patients had positive anti-NMDA antibody at baseline or at follow-up. The study failed to detect anti-NMDA antibodies in patients with acute psychotic states with clinical suspicion of autoimmunity. This does not rule out other mechanisms of NMDA receptor dysfunction in these patients.
•Patients with acute psychosis and features of possible autoimmune etiology were taken.•The serology was negative at baseline and at follow-up after a period of few weeks.•The study does not rule out other possible causes of NMDA-receptor dysfunction.</description><subject>Acute Disease</subject><subject>acute psychosis</subject><subject>Adolescent</subject><subject>Autoantibodies - blood</subject><subject>autoimmunity</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>N-methyl-D-aspartate receptors</subject><subject>NR1 NMDA receptor</subject><subject>Psychotic disorders</subject><subject>Psychotic Disorders - blood</subject><subject>Psychotic Disorders - immunology</subject><subject>Psychotic Disorders - physiopathology</subject><subject>Receptors, N-Methyl-D-Aspartate - immunology</subject><subject>Young Adult</subject><issn>1876-2018</issn><issn>1876-2026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPHDEQhC0UFAjJD-AS-ZjLTLrtecJpRRJA4nEhuVpeu0fxanc82B7E_PsYLXDMqVulqlL3x9gpQomAzfdNqTdTKQD7EuoShDxgx9i1TSFANB_ed-yO2KcYNwBNJ6v2IzuSiAJr2RyzP6sxueLu9seKBzI0JR-4ztLa24VPPrrknlxauBu5NnMiPsXF_PXJGR6TThTP-Grk9DxtfdA5vGR5tstndjjobaQvr_OE_f718-Hiqri5v7y-WN0URtYyFUgAupfQVkh2EKIisLY1fT3UtoJ870C10A21LYKBoWqrTsgaLdJa2E5KecK-7Xun4B9nikntXDS03eqR_ByVEBK7qu2hz1bcW03wMQYa1BTcTodFIagXnGqjMk71glNBrTLOnPn6Wj-vd2TfE2_8suF8b6D85JOjoKJxNBqyLuNMynr3n_p_Av-FNg</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Bharadwaj, Balaji</creator><creator>Sathyanarayanan, Gopinath</creator><creator>Kaliaperumal, Venkatesh</creator><creator>Dhodapkar, Rahul</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201906</creationdate><title>Anti-NMDA receptor antibody positivity in acute psychotic states: An exploratory study</title><author>Bharadwaj, Balaji ; Sathyanarayanan, Gopinath ; Kaliaperumal, Venkatesh ; Dhodapkar, Rahul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-1e00a930741edf224e0dd7c95f5d40006fe52a6e7710c0f47482351d1eb2d8333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute Disease</topic><topic>acute psychosis</topic><topic>Adolescent</topic><topic>Autoantibodies - blood</topic><topic>autoimmunity</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>N-methyl-D-aspartate receptors</topic><topic>NR1 NMDA receptor</topic><topic>Psychotic disorders</topic><topic>Psychotic Disorders - blood</topic><topic>Psychotic Disorders - immunology</topic><topic>Psychotic Disorders - physiopathology</topic><topic>Receptors, N-Methyl-D-Aspartate - immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bharadwaj, Balaji</creatorcontrib><creatorcontrib>Sathyanarayanan, Gopinath</creatorcontrib><creatorcontrib>Kaliaperumal, Venkatesh</creatorcontrib><creatorcontrib>Dhodapkar, Rahul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Asian journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bharadwaj, Balaji</au><au>Sathyanarayanan, Gopinath</au><au>Kaliaperumal, Venkatesh</au><au>Dhodapkar, Rahul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-NMDA receptor antibody positivity in acute psychotic states: An exploratory study</atitle><jtitle>Asian journal of psychiatry</jtitle><addtitle>Asian J Psychiatr</addtitle><date>2019-06</date><risdate>2019</risdate><volume>43</volume><spage>95</spage><epage>98</epage><pages>95-98</pages><issn>1876-2018</issn><eissn>1876-2026</eissn><abstract>The glutamatergic theory of schizophrenia postulates N-methyl-D-aspartate receptor (NMDA-R) dysfunction. Anti-NMDA receptor antibodies may be present in some patients with psychosis. Fifteen patients presenting with acute psychotic states having one additional clinical feature suggestive of autoimmune etiology were recruited. Serum antibodies against NMDA-receptor were tested at baseline and at follow-up using Indirect Immunofluorescence Technique. None of the 15 patients had positive anti-NMDA antibody at baseline or at follow-up. The study failed to detect anti-NMDA antibodies in patients with acute psychotic states with clinical suspicion of autoimmunity. This does not rule out other mechanisms of NMDA receptor dysfunction in these patients. The glutamatergic theory of schizophrenia postulates N-methyl-D-aspartate receptor (NMDA-R) dysfunction. Anti-NMDA receptor antibodies may be present in some patients with psychosis. Fifteen patients presenting with acute psychotic states having one additional clinical feature suggestive of autoimmune etiology were recruited. Serum antibodies against NMDA-receptor were tested at baseline and at follow-up using Indirect Immunofluorescence Technique. None of the 15 patients had positive anti-NMDA antibody at baseline or at follow-up. The study failed to detect anti-NMDA antibodies in patients with acute psychotic states with clinical suspicion of autoimmunity. This does not rule out other mechanisms of NMDA receptor dysfunction in these patients.
•Patients with acute psychosis and features of possible autoimmune etiology were taken.•The serology was negative at baseline and at follow-up after a period of few weeks.•The study does not rule out other possible causes of NMDA-receptor dysfunction.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31121536</pmid><doi>10.1016/j.ajp.2019.05.023</doi><tpages>4</tpages></addata></record> |
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| subjects | Acute Disease acute psychosis Adolescent Autoantibodies - blood autoimmunity Female Fluorescent Antibody Technique, Indirect Follow-Up Studies Humans Male N-methyl-D-aspartate receptors NR1 NMDA receptor Psychotic disorders Psychotic Disorders - blood Psychotic Disorders - immunology Psychotic Disorders - physiopathology Receptors, N-Methyl-D-Aspartate - immunology Young Adult |
| title | Anti-NMDA receptor antibody positivity in acute psychotic states: An exploratory study |
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