Film-nanoparticle composite for enhanced oral delivery of alpha-casozepine

[Display omitted] •Alpha-casozepine peptide was successfully entrapped within PLGA nanoparticles.•Nanoparticles were incorporated in guar-gum films for improved peptide buccal permeability.•Nanoparticles were incorporated in guar-gum films for improved peptide intestinal permeability.•Film-nanoparti...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2019-09, Vol.181, p.149-157
Hauptverfasser:	Castro, Pedro M., Baptista, Patrícia, Zuccheri, Giampaolo, Madureira, Ana Raquel, Sarmento, Bruno, Pintado, Manuela E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Alpha-Casozepine Buccal delivery Caseins - administration & dosage Caseins - chemistry Caseins - pharmacology Cell Survival - drug effects Coculture Techniques Dose-Response Relationship, Drug Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Delivery Systems Humans Mitochondria - drug effects Nanoparticles - administration & dosage Nanoparticles - chemistry Oral delivery Oral films Peptide Fragments - administration & dosage Peptide Fragments - chemistry Peptide Fragments - pharmacology PLGA nanoparticles Polyglycolic Acid - administration & dosage Polyglycolic Acid - chemistry Structure-Activity Relationship Tumor Cells, Cultured
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