Improved synthesis and characterization of cholesteryl oleate-loaded cationic solid lipid nanoparticles with high transfection efficiency for gene therapy applications

[Display omitted] •A cholesteryl oleate-loaded cSLNs formulation was improved to enhance performance.•The obtained nanoparticles showed good particle size and zeta potential.•The obtained nanoparticles exhibited enhanced stability.•Optimal binding capacity and transfection efficiency was achieved.•S...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2019-08, Vol.180, p.159-167
Hauptverfasser:	Suñé-Pou, Marc, Limeres, María J., Nofrerias, Isaac, Nardi-Ricart, Anna, Prieto-Sánchez, Silvia, El-Yousfi, Younes, Pérez-Lozano, Pilar, García-Montoya, Encarna, Miñarro-Carmona, Montserrat, Ticó, Josep Ramón, Hernández-Munain, Cristina, Suñé, Carlos, Suñé-Negre, Josep Mª
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Carbocyanines - chemistry Carbocyanines - metabolism Cations Cholesterol Esters - chemistry Cholesteryl oleate Factor Analysis, Statistical Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism Gene therapy Gene Transfer Techniques HeLa Cells Humans Microscopy, Fluorescence Nanoparticles - chemistry Nanoparticles - metabolism Nanoparticles - ultrastructure Particle Size Plasmids - chemistry Plasmids - metabolism Poloxamer - chemistry QbD RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Solid lipid nanoparticles Stearic Acids - chemistry Storage conditions Transfection - methods Transfection efficiency
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