Prevention by L-carnitine of DNA damage induced by 3-hydroxy-3-methylglutaric and 3-methylglutaric acids and experimental evidence of lipid and DNA damage in patients with 3-hydroxy-3-methylglutaric aciduria

3-hydroxy-3-methylglutaric aciduria (HMGA) is an inherited disorder of the leucine catabolic pathway in which occurs a deficiency of the 3-hydroxy-3-methylglutaryl-CoA lyase enzyme. Therefore, the organic acids 3-hydroxy-3-methylglutaric (HMG) and 3-methylglutaric (MGA), mainly, accumulate in tissue...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of biochemistry and biophysics 2019-06, Vol.668, p.16-22
Hauptverfasser:	Delgado, Camila Aguilar, Balbueno Guerreiro, Gilian Batista, Diaz Jacques, Carlos Eduardo, de Moura Coelho, Daniella, Sitta, Angela, Manfredini, Vanusa, Wajner, Moacir, Vargas, Carmen Regla
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxy-3-methylglutaric aciduria 8-Hydroxy-2'-Deoxyguanosine - urine Acetyl-CoA C-Acetyltransferase - deficiency Acetyl-CoA C-Acetyltransferase - metabolism Acetyl-CoA C-Acetyltransferase - urine Adolescent Amino Acid Metabolism, Inborn Errors - drug therapy Amino Acid Metabolism, Inborn Errors - metabolism Amino Acid Metabolism, Inborn Errors - urine Carnitine Carnitine - therapeutic use Child Child, Preschool Dinoprost - analogs & derivatives Dinoprost - urine DNA damage DNA Damage - drug effects Guanine - analogs & derivatives Guanine - urine Guanosine - analogs & derivatives Guanosine - urine Humans Infant Lipid Peroxidation - drug effects Meglutol - analogs & derivatives Meglutol - metabolism Organic acidurias Oxidative damage Oxidative stress
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!