Structural basis for eIF2B inhibition in integrated stress response

A core event in the integrated stress response, an adaptive pathway common to all eukaryotic cells in response to various stress stimuli, is the phosphorylation of eukaryotic translation initiation factor 2 (eIF2). Normally, unphosphorylated eIF2 transfers the methionylated initiator tRNA to the rib...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2019-05, Vol.364 (6439), p.495-499
Hauptverfasser:	Kashiwagi, Kazuhiro, Yokoyama, Takeshi, Nishimoto, Madoka, Takahashi, Mari, Sakamoto, Ayako, Yonemochi, Mayumi, Shirouzu, Mikako, Ito, Takuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Cellular stress response Crystal structure Crystallography Electron microscopy Eukaryotes Exchanging Gene expression Guanine Guanine nucleotide exchange factor Guanosine Head injuries Initiation factor eIF-2 Kinases Locks Microscopy Neurodegenerative diseases Neurological diseases Phosphorylation Protein biosynthesis Protein synthesis Stimuli Stress response Therapeutic applications Translation Traumatic brain injury tRNA
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