Deciphering the binding of dutasteride with human alpha-2-macroglobulin: Molecular docking and calorimetric approach

Dutasteride is a pharmacologically important drug employed to treat prostate cancer. Alpha-2-macroglobulin (α2M) is the primary proteinase inhibitor and is abundant in vertebrate plasma. Previous studies have shown that α2M levels were down regulated in prostate cancer. Our results of functional ass...

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Veröffentlicht in:	International journal of biological macromolecules 2019-07, Vol.133, p.1081-1089
Hauptverfasser:	Zia, Mohammad Khalid, Siddiqui, Tooba, Ali, Syed Saqib, Ahsan, Haseeb, Khan, Fahim Halim
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-2-macroglobulin Antiproteinase Benign prostatic hyperplasia Dutasteride Prostate cancer
Online-Zugang:	Volltext
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