Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial

Abstract Background and aims We aimed to examine, for the first time, the effect of cannabidiol (CBD) and palmitoylethanolamide (PEA) on the permeability of the human gastrointestinal tract in vitro, ex vivo, and in vivo. Methods Flux measurements of fluorescein-labeled dextrans 10 (FD10) and fluore...

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Veröffentlicht in:	Inflammatory bowel diseases 2019-05, Vol.25 (6), p.1006-1018
Hauptverfasser:	Couch, Daniel G, Cook, Hollie, Ortori, Catherine, Barrett, Dave, Lund, Jonathan N, O'Sullivan, Saoirse E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Aspirin Biological response modifiers Caco-2 Cells Cannabidiol - administration & dosage Cell Membrane Permeability - drug effects Clinical trials Dextran Double-Blind Method Enzyme-linked immunosorbent assay Ethanolamines - administration & dosage Fluorescein Follow-Up Studies Gastrointestinal diseases Gastrointestinal system Gastrointestinal Tract - drug effects Humans Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - pathology Interferon gamma Lactulose Liquid chromatography Male Mass spectrometry Medical research Medicine, Experimental Middle Aged Nitric oxide Palmitic Acids - administration & dosage Permeability Prevention Protein kinases RNA Tumor necrosis factor Young Adult
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