Capsule Retention in Crohn’s Disease: A Meta-analysis
This systematic review showed lower capsule retention rates in suspected and established Crohn’s disease than older literature. Retention rates were further reduced after patency capsule and cross-sectional imaging. Retention rates were also lower in pediatric compared with adult Crohn’s disease. Ab...
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| Veröffentlicht in: | Inflammatory bowel diseases 2020-01, Vol.26 (1), p.33-42 |
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| creator | Pasha, Shabana F Pennazio, Marco Rondonotti, Emanuele Wolf, Douglas Buras, Matthew R Albert, Jörg G Cohen, Stanley A Cotter, Jose D’Haens, Geert Eliakim, Rami Rubin, David T Leighton, Jonathan A |
| description | This systematic review showed lower capsule retention rates in suspected and established Crohn’s disease than older literature. Retention rates were further reduced after patency capsule and cross-sectional imaging. Retention rates were also lower in pediatric compared with adult Crohn’s disease.
Abstract
Background
The main factor that limits wider utilization of capsule endoscopy (CE) in Crohn’s disease (CD) is the potential risk of retention. The aim of this systematic review was to evaluate capsule retention rates in adult and pediatric CD and determine if retention risk is reduced in established CD (ECD) with patency capsule (PC) or magnetic resonance/computed tomography (MR/CT) enterography.
Methods
Studies of CD patients undergoing CE that reported retention were identified. Pooled estimates for retention rates and relative risk in ECD to suspected CD (SCD) were calculated. All hypothesis tests were 2-sided; statistical significance was set at a P value of |
| doi_str_mv | 10.1093/ibd/izz083 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2229233751</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A618030687</galeid><oup_id>10.1093/ibd/izz083</oup_id><sourcerecordid>A618030687</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-8b696a50fea3cee1489a845e1fc98c8ed8d46d2f6a089e2418f6e992d7b2f8033</originalsourceid><addsrcrecordid>eNp90N1KwzAYBuAgipvTEy9ACiKI0C0_bZp4NuovTATR45C2XzTStbNpD7Yjb8Pb80rM6BQEke8gITzfS3gROiR4TLBkE5sVE7taYcG20JDEjIeRiKJtf8eJCLGUYoD2nHvFmPqRu2jACI5xwvgQJaleuK6E4AFaqFpbV4GtgrSpX6rP9w8XXFgH2sF5MA3uoNWhrnS5dNbtox2jSwcHm3OEnq4uH9ObcHZ_fZtOZ2EexbgNRcYl1zE2oFkOQCIhtYhiICaXIhdQiCLiBTVcYyGBRkQYDlLSIsmoEZixETrtcxdN_daBa9XcuhzKUldQd05RSiVlLImJp8c9fdYlKFuZum10vuZqyokPw1wkXo3_UH4KmNu8rsBY__5r4axfyJvauQaMWjR2rpulIlit-1e-f9X37_HR5rtdNofih34X7sFJD-pu8V_QF-bmjA4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2229233751</pqid></control><display><type>article</type><title>Capsule Retention in Crohn’s Disease: A Meta-analysis</title><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Pasha, Shabana F ; Pennazio, Marco ; Rondonotti, Emanuele ; Wolf, Douglas ; Buras, Matthew R ; Albert, Jörg G ; Cohen, Stanley A ; Cotter, Jose ; D’Haens, Geert ; Eliakim, Rami ; Rubin, David T ; Leighton, Jonathan A</creator><creatorcontrib>Pasha, Shabana F ; Pennazio, Marco ; Rondonotti, Emanuele ; Wolf, Douglas ; Buras, Matthew R ; Albert, Jörg G ; Cohen, Stanley A ; Cotter, Jose ; D’Haens, Geert ; Eliakim, Rami ; Rubin, David T ; Leighton, Jonathan A</creatorcontrib><description>This systematic review showed lower capsule retention rates in suspected and established Crohn’s disease than older literature. Retention rates were further reduced after patency capsule and cross-sectional imaging. Retention rates were also lower in pediatric compared with adult Crohn’s disease.
Abstract
Background
The main factor that limits wider utilization of capsule endoscopy (CE) in Crohn’s disease (CD) is the potential risk of retention. The aim of this systematic review was to evaluate capsule retention rates in adult and pediatric CD and determine if retention risk is reduced in established CD (ECD) with patency capsule (PC) or magnetic resonance/computed tomography (MR/CT) enterography.
Methods
Studies of CD patients undergoing CE that reported retention were identified. Pooled estimates for retention rates and relative risk in ECD to suspected CD (SCD) were calculated. All hypothesis tests were 2-sided; statistical significance was set at a P value of <0.05.
Results
In the overall CD cohort, retention rates were 3.32% (95% confidence interval [CI], 2.62%–4.2%): 4.63% (95% CI, 3.42%–6.25%) and 2.35% (95% CI, 1.31%–4.19%) in ECD and SCD, respectively. Retention rates were 3.49% (95% CI, 2.73%–4.46%) and 1.64% (95% CI, 0.68%–3.89%) in adult and pediatric CD, respectively. Retention risk in adult ECD was 3.4 times higher than SCD, but there was no difference in retention risk in pediatric ECD compared with SCD. Retention rates in ECD were decreased after patency capsule (2.88%; 95% CI, 1.74%–4.74%) and MR/CT enterography (2.32%; 95% CI, 0.87%–6.03%).
Conclusions
In comparison with older literature, this meta-analysis demonstrates lower CE retention rates in SCD and ECD. Retention rates in pediatric CD were lower than in adult CD. Retention rates in adult ECD were higher than SCD, but there were no differences between pediatric ECD and SCD. Retention rates in ECD were lower after negative PC or MR/CT enterography.</description><identifier>ISSN: 1078-0998</identifier><identifier>EISSN: 1536-4844</identifier><identifier>DOI: 10.1093/ibd/izz083</identifier><identifier>PMID: 31050736</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Endoscopy ; Medical research ; Medicine, Experimental ; Pediatrics</subject><ispartof>Inflammatory bowel diseases, 2020-01, Vol.26 (1), p.33-42</ispartof><rights>2019 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2019</rights><rights>2019 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-8b696a50fea3cee1489a845e1fc98c8ed8d46d2f6a089e2418f6e992d7b2f8033</citedby><cites>FETCH-LOGICAL-c450t-8b696a50fea3cee1489a845e1fc98c8ed8d46d2f6a089e2418f6e992d7b2f8033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31050736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pasha, Shabana F</creatorcontrib><creatorcontrib>Pennazio, Marco</creatorcontrib><creatorcontrib>Rondonotti, Emanuele</creatorcontrib><creatorcontrib>Wolf, Douglas</creatorcontrib><creatorcontrib>Buras, Matthew R</creatorcontrib><creatorcontrib>Albert, Jörg G</creatorcontrib><creatorcontrib>Cohen, Stanley A</creatorcontrib><creatorcontrib>Cotter, Jose</creatorcontrib><creatorcontrib>D’Haens, Geert</creatorcontrib><creatorcontrib>Eliakim, Rami</creatorcontrib><creatorcontrib>Rubin, David T</creatorcontrib><creatorcontrib>Leighton, Jonathan A</creatorcontrib><title>Capsule Retention in Crohn’s Disease: A Meta-analysis</title><title>Inflammatory bowel diseases</title><addtitle>Inflamm Bowel Dis</addtitle><description>This systematic review showed lower capsule retention rates in suspected and established Crohn’s disease than older literature. Retention rates were further reduced after patency capsule and cross-sectional imaging. Retention rates were also lower in pediatric compared with adult Crohn’s disease.
Abstract
Background
The main factor that limits wider utilization of capsule endoscopy (CE) in Crohn’s disease (CD) is the potential risk of retention. The aim of this systematic review was to evaluate capsule retention rates in adult and pediatric CD and determine if retention risk is reduced in established CD (ECD) with patency capsule (PC) or magnetic resonance/computed tomography (MR/CT) enterography.
Methods
Studies of CD patients undergoing CE that reported retention were identified. Pooled estimates for retention rates and relative risk in ECD to suspected CD (SCD) were calculated. All hypothesis tests were 2-sided; statistical significance was set at a P value of <0.05.
Results
In the overall CD cohort, retention rates were 3.32% (95% confidence interval [CI], 2.62%–4.2%): 4.63% (95% CI, 3.42%–6.25%) and 2.35% (95% CI, 1.31%–4.19%) in ECD and SCD, respectively. Retention rates were 3.49% (95% CI, 2.73%–4.46%) and 1.64% (95% CI, 0.68%–3.89%) in adult and pediatric CD, respectively. Retention risk in adult ECD was 3.4 times higher than SCD, but there was no difference in retention risk in pediatric ECD compared with SCD. Retention rates in ECD were decreased after patency capsule (2.88%; 95% CI, 1.74%–4.74%) and MR/CT enterography (2.32%; 95% CI, 0.87%–6.03%).
Conclusions
In comparison with older literature, this meta-analysis demonstrates lower CE retention rates in SCD and ECD. Retention rates in pediatric CD were lower than in adult CD. Retention rates in adult ECD were higher than SCD, but there were no differences between pediatric ECD and SCD. Retention rates in ECD were lower after negative PC or MR/CT enterography.</description><subject>Endoscopy</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Pediatrics</subject><issn>1078-0998</issn><issn>1536-4844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp90N1KwzAYBuAgipvTEy9ACiKI0C0_bZp4NuovTATR45C2XzTStbNpD7Yjb8Pb80rM6BQEke8gITzfS3gROiR4TLBkE5sVE7taYcG20JDEjIeRiKJtf8eJCLGUYoD2nHvFmPqRu2jACI5xwvgQJaleuK6E4AFaqFpbV4GtgrSpX6rP9w8XXFgH2sF5MA3uoNWhrnS5dNbtox2jSwcHm3OEnq4uH9ObcHZ_fZtOZ2EexbgNRcYl1zE2oFkOQCIhtYhiICaXIhdQiCLiBTVcYyGBRkQYDlLSIsmoEZixETrtcxdN_daBa9XcuhzKUldQd05RSiVlLImJp8c9fdYlKFuZum10vuZqyokPw1wkXo3_UH4KmNu8rsBY__5r4axfyJvauQaMWjR2rpulIlit-1e-f9X37_HR5rtdNofih34X7sFJD-pu8V_QF-bmjA4</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Pasha, Shabana F</creator><creator>Pennazio, Marco</creator><creator>Rondonotti, Emanuele</creator><creator>Wolf, Douglas</creator><creator>Buras, Matthew R</creator><creator>Albert, Jörg G</creator><creator>Cohen, Stanley A</creator><creator>Cotter, Jose</creator><creator>D’Haens, Geert</creator><creator>Eliakim, Rami</creator><creator>Rubin, David T</creator><creator>Leighton, Jonathan A</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200101</creationdate><title>Capsule Retention in Crohn’s Disease: A Meta-analysis</title><author>Pasha, Shabana F ; Pennazio, Marco ; Rondonotti, Emanuele ; Wolf, Douglas ; Buras, Matthew R ; Albert, Jörg G ; Cohen, Stanley A ; Cotter, Jose ; D’Haens, Geert ; Eliakim, Rami ; Rubin, David T ; Leighton, Jonathan A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-8b696a50fea3cee1489a845e1fc98c8ed8d46d2f6a089e2418f6e992d7b2f8033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Endoscopy</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Pediatrics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pasha, Shabana F</creatorcontrib><creatorcontrib>Pennazio, Marco</creatorcontrib><creatorcontrib>Rondonotti, Emanuele</creatorcontrib><creatorcontrib>Wolf, Douglas</creatorcontrib><creatorcontrib>Buras, Matthew R</creatorcontrib><creatorcontrib>Albert, Jörg G</creatorcontrib><creatorcontrib>Cohen, Stanley A</creatorcontrib><creatorcontrib>Cotter, Jose</creatorcontrib><creatorcontrib>D’Haens, Geert</creatorcontrib><creatorcontrib>Eliakim, Rami</creatorcontrib><creatorcontrib>Rubin, David T</creatorcontrib><creatorcontrib>Leighton, Jonathan A</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammatory bowel diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pasha, Shabana F</au><au>Pennazio, Marco</au><au>Rondonotti, Emanuele</au><au>Wolf, Douglas</au><au>Buras, Matthew R</au><au>Albert, Jörg G</au><au>Cohen, Stanley A</au><au>Cotter, Jose</au><au>D’Haens, Geert</au><au>Eliakim, Rami</au><au>Rubin, David T</au><au>Leighton, Jonathan A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Capsule Retention in Crohn’s Disease: A Meta-analysis</atitle><jtitle>Inflammatory bowel diseases</jtitle><addtitle>Inflamm Bowel Dis</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>26</volume><issue>1</issue><spage>33</spage><epage>42</epage><pages>33-42</pages><issn>1078-0998</issn><eissn>1536-4844</eissn><abstract>This systematic review showed lower capsule retention rates in suspected and established Crohn’s disease than older literature. Retention rates were further reduced after patency capsule and cross-sectional imaging. Retention rates were also lower in pediatric compared with adult Crohn’s disease.
Abstract
Background
The main factor that limits wider utilization of capsule endoscopy (CE) in Crohn’s disease (CD) is the potential risk of retention. The aim of this systematic review was to evaluate capsule retention rates in adult and pediatric CD and determine if retention risk is reduced in established CD (ECD) with patency capsule (PC) or magnetic resonance/computed tomography (MR/CT) enterography.
Methods
Studies of CD patients undergoing CE that reported retention were identified. Pooled estimates for retention rates and relative risk in ECD to suspected CD (SCD) were calculated. All hypothesis tests were 2-sided; statistical significance was set at a P value of <0.05.
Results
In the overall CD cohort, retention rates were 3.32% (95% confidence interval [CI], 2.62%–4.2%): 4.63% (95% CI, 3.42%–6.25%) and 2.35% (95% CI, 1.31%–4.19%) in ECD and SCD, respectively. Retention rates were 3.49% (95% CI, 2.73%–4.46%) and 1.64% (95% CI, 0.68%–3.89%) in adult and pediatric CD, respectively. Retention risk in adult ECD was 3.4 times higher than SCD, but there was no difference in retention risk in pediatric ECD compared with SCD. Retention rates in ECD were decreased after patency capsule (2.88%; 95% CI, 1.74%–4.74%) and MR/CT enterography (2.32%; 95% CI, 0.87%–6.03%).
Conclusions
In comparison with older literature, this meta-analysis demonstrates lower CE retention rates in SCD and ECD. Retention rates in pediatric CD were lower than in adult CD. Retention rates in adult ECD were higher than SCD, but there were no differences between pediatric ECD and SCD. Retention rates in ECD were lower after negative PC or MR/CT enterography.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>31050736</pmid><doi>10.1093/ibd/izz083</doi><tpages>10</tpages></addata></record> |
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| ispartof | Inflammatory bowel diseases, 2020-01, Vol.26 (1), p.33-42 |
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| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current) |
| subjects | Endoscopy Medical research Medicine, Experimental Pediatrics |
| title | Capsule Retention in Crohn’s Disease: A Meta-analysis |
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