Novel choline analog 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects

The search for new drugs remains an important focus for the safe and effective treatment of cardiovascular diseases. Previous evidence has shown that choline analogs can offer therapeutic benefit for cardiovascular complications. The current study investigates the effects of 2-(4-((1-phenyl-1 H -pyr...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2019-09, Vol.392 (9), p.1071-1083
Hauptverfasser:	Menegatti, Ricardo, Carvalho, Flávio S., Lião, Luciano M., Villavicencio, Bianca, Verli, Hugo, Mourão, Aline A., Xavier, Carlos H., Castro, Carlos H., Pedrino, Gustavo R., Franco, Octavio L., Oliveira-Silva, Iransé, Ashpole, Nicole M., Silva, Osmar Nascimento, Costa, Elson A., Fajemiroye, James O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Antagonists Antihypertensives Aorta Atropine Biomedical and Life Sciences Biomedicine Blood pressure Cardiovascular diseases Cardiovascular system Choline Complications Computer applications Endothelium Heart rate Hypotension Intracerebroventricular administration Intravenous administration Medical treatment Neurosciences NG-Nitroarginine methyl ester Nitric oxide Nitric-oxide synthase Original Article Pharmacology/Toxicology Pirenzepine Renal plexus Rodents Sympathetic nerves
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