RNA modifications regulating cell fate in cancer
The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emer...
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| Veröffentlicht in: | Nature cell biology 2019-05, Vol.21 (5), p.552-559 |
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| creator | Delaunay, Sylvain Frye, Michaela |
| description | The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributor to cancer. By modulating cell survival, differentiation, migration and drug resistance, RNA modifications add another regulatory layer of complexity to most aspects of tumourigenesis.
Sylvain et al. review cellular functions of various RNA modifications and their roles in regulating cell fate in normal and cancer tissues. |
| doi_str_mv | 10.1038/s41556-019-0319-0 |
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Sylvain et al. review cellular functions of various RNA modifications and their roles in regulating cell fate in normal and cancer tissues.</description><subject>13</subject><subject>631/337/1645/2570</subject><subject>631/67</subject><subject>631/67/71</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer</subject><subject>Cancer genetics</subject><subject>Cancer Research</subject><subject>Cell Biology</subject><subject>Cell differentiation</subject><subject>Cell Differentiation - genetics</subject><subject>Cell fate</subject><subject>Cell Lineage - genetics</subject><subject>Cell migration</subject><subject>Cell Movement - genetics</subject><subject>Cell Proliferation - genetics</subject><subject>Cell regulation</subject><subject>Cell survival</subject><subject>Cell Survival - genetics</subject><subject>Developmental Biology</subject><subject>Developmental disabilities</subject><subject>DNA</subject><subject>Drug resistance</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Messenger RNA</subject><subject>Neoplasms - 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Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributor to cancer. By modulating cell survival, differentiation, migration and drug resistance, RNA modifications add another regulatory layer of complexity to most aspects of tumourigenesis.
Sylvain et al. review cellular functions of various RNA modifications and their roles in regulating cell fate in normal and cancer tissues.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31048770</pmid><doi>10.1038/s41556-019-0319-0</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-5636-6840</orcidid></addata></record> |
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| subjects | 13 631/337/1645/2570 631/67 631/67/71 Biochemistry Biomedical and Life Sciences Cancer Cancer genetics Cancer Research Cell Biology Cell differentiation Cell Differentiation - genetics Cell fate Cell Lineage - genetics Cell migration Cell Movement - genetics Cell Proliferation - genetics Cell regulation Cell survival Cell Survival - genetics Developmental Biology Developmental disabilities DNA Drug resistance Gene expression Gene Expression Regulation, Neoplastic Genes Genetic aspects Health aspects Humans Life Sciences Messenger RNA Neoplasms - genetics Neoplasms - pathology Organic chemistry Review Article Ribonucleic acid RNA RNA - genetics RNA - metabolism RNA modification RNA Processing, Post-Transcriptional - genetics Stem Cells Transcription (Genetics) Translation (Genetics) |
| title | RNA modifications regulating cell fate in cancer |
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