The use of an acellular matrix derived from human dermis for the treatment of full-thickness skin wounds
Full-thickness skin wounds occur in many different clinical cases and the use of biological acellular dermal matrices (ADMs) to reconstruct the damaged area is increasing in the field of plastic and reconstructive surgery. In particular, the ability of ADMs to maintain the structural properties of e...
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| Veröffentlicht in: | Cell and tissue banking 2019-06, Vol.20 (2), p.183-192 |
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| creator | Bondioli, Elena Purpura, Valeria Orlandi, Catuscia Carboni, Andrea Minghetti, Paola Cenacchi, Giovanna De Luca, Giovanni Capirossi, Daniela Nigrisoli, Evandro Melandri, Davide |
| description | Full-thickness skin wounds occur in many different clinical cases and the use of biological acellular dermal matrices (ADMs) to reconstruct the damaged area is increasing in the field of plastic and reconstructive surgery. In particular, the ability of ADMs to maintain the structural properties of extracellular matrix as well as to provide a suitable environment for cell growth makes their use suitable for the improvement of wound healing and the reduction of side effects deriving from contracture and scar tissue formation. In this study, we describe the clinical use of a recently developed human dermal matrix (HDM) in combination with graft skin as an alternative reconstructive solution for the treatment of full-thickness skin wounds. The HDM was applied in combination with autologous graft skin on three different clinical cases in which full-thickness skin wounds occurred. The clinical outcomes were evaluated in the patients during their follow-up. Histological as well as ultra-structural analysis were also performed on skin biopsy of the clinical case 3 one year after the treatment with HDM. The use of HDM stimulates the wound healing process in all clinical cases of full-thickness skin wounds here described with a functional and aesthetic rescue of the damaged area. Histological and ultra-structural analysis show a regenerative healing of the wound area with well-organized/oriented connective tissue in which cellular infiltration as well as blood vessels are evident. Our results support the clinical use of HDM as a permanent dermal replacement for the treatment of full-thickness skin wounds. |
| doi_str_mv | 10.1007/s10561-019-09755-w |
| format | Article |
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In particular, the ability of ADMs to maintain the structural properties of extracellular matrix as well as to provide a suitable environment for cell growth makes their use suitable for the improvement of wound healing and the reduction of side effects deriving from contracture and scar tissue formation. In this study, we describe the clinical use of a recently developed human dermal matrix (HDM) in combination with graft skin as an alternative reconstructive solution for the treatment of full-thickness skin wounds. The HDM was applied in combination with autologous graft skin on three different clinical cases in which full-thickness skin wounds occurred. The clinical outcomes were evaluated in the patients during their follow-up. Histological as well as ultra-structural analysis were also performed on skin biopsy of the clinical case 3 one year after the treatment with HDM. The use of HDM stimulates the wound healing process in all clinical cases of full-thickness skin wounds here described with a functional and aesthetic rescue of the damaged area. Histological and ultra-structural analysis show a regenerative healing of the wound area with well-organized/oriented connective tissue in which cellular infiltration as well as blood vessels are evident. Our results support the clinical use of HDM as a permanent dermal replacement for the treatment of full-thickness skin wounds.</description><identifier>ISSN: 1389-9333</identifier><identifier>EISSN: 1573-6814</identifier><identifier>DOI: 10.1007/s10561-019-09755-w</identifier><identifier>PMID: 30767153</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Acellular Dermis ; Autografts ; Biomedical and Life Sciences ; Biomedicine ; Biopsy ; Blood vessels ; Cell Biology ; Dermis ; Extracellular matrix ; Extracellular Matrix - physiology ; Humans ; Life Sciences ; Plastic surgery ; Reconstructive surgery ; Skin ; Skin & tissue grafts ; Skin - injuries ; Skin grafts ; Skin Transplantation - methods ; Skin, Artificial ; Structural analysis ; Surgery ; Tissues ; Transplant Surgery ; Wound healing ; Wound Healing - physiology</subject><ispartof>Cell and tissue banking, 2019-06, Vol.20 (2), p.183-192</ispartof><rights>Springer Nature B.V. 2019</rights><rights>Cell and Tissue Banking is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-cf8a73dcb0149a33faf7e6f1d8524a980fb59efd8fb330896e0b6380bfc3baa43</citedby><cites>FETCH-LOGICAL-c375t-cf8a73dcb0149a33faf7e6f1d8524a980fb59efd8fb330896e0b6380bfc3baa43</cites><orcidid>0000-0002-1272-313X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10561-019-09755-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10561-019-09755-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30767153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bondioli, Elena</creatorcontrib><creatorcontrib>Purpura, Valeria</creatorcontrib><creatorcontrib>Orlandi, Catuscia</creatorcontrib><creatorcontrib>Carboni, Andrea</creatorcontrib><creatorcontrib>Minghetti, Paola</creatorcontrib><creatorcontrib>Cenacchi, Giovanna</creatorcontrib><creatorcontrib>De Luca, Giovanni</creatorcontrib><creatorcontrib>Capirossi, Daniela</creatorcontrib><creatorcontrib>Nigrisoli, Evandro</creatorcontrib><creatorcontrib>Melandri, Davide</creatorcontrib><title>The use of an acellular matrix derived from human dermis for the treatment of full-thickness skin wounds</title><title>Cell and tissue banking</title><addtitle>Cell Tissue Bank</addtitle><addtitle>Cell Tissue Bank</addtitle><description>Full-thickness skin wounds occur in many different clinical cases and the use of biological acellular dermal matrices (ADMs) to reconstruct the damaged area is increasing in the field of plastic and reconstructive surgery. In particular, the ability of ADMs to maintain the structural properties of extracellular matrix as well as to provide a suitable environment for cell growth makes their use suitable for the improvement of wound healing and the reduction of side effects deriving from contracture and scar tissue formation. In this study, we describe the clinical use of a recently developed human dermal matrix (HDM) in combination with graft skin as an alternative reconstructive solution for the treatment of full-thickness skin wounds. The HDM was applied in combination with autologous graft skin on three different clinical cases in which full-thickness skin wounds occurred. The clinical outcomes were evaluated in the patients during their follow-up. Histological as well as ultra-structural analysis were also performed on skin biopsy of the clinical case 3 one year after the treatment with HDM. The use of HDM stimulates the wound healing process in all clinical cases of full-thickness skin wounds here described with a functional and aesthetic rescue of the damaged area. Histological and ultra-structural analysis show a regenerative healing of the wound area with well-organized/oriented connective tissue in which cellular infiltration as well as blood vessels are evident. Our results support the clinical use of HDM as a permanent dermal replacement for the treatment of full-thickness skin wounds.</description><subject>Acellular Dermis</subject><subject>Autografts</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biopsy</subject><subject>Blood vessels</subject><subject>Cell Biology</subject><subject>Dermis</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - physiology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Plastic surgery</subject><subject>Reconstructive surgery</subject><subject>Skin</subject><subject>Skin & tissue grafts</subject><subject>Skin - injuries</subject><subject>Skin grafts</subject><subject>Skin Transplantation - methods</subject><subject>Skin, Artificial</subject><subject>Structural analysis</subject><subject>Surgery</subject><subject>Tissues</subject><subject>Transplant Surgery</subject><subject>Wound healing</subject><subject>Wound Healing - 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physiology</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Plastic surgery</topic><topic>Reconstructive surgery</topic><topic>Skin</topic><topic>Skin & tissue grafts</topic><topic>Skin - injuries</topic><topic>Skin grafts</topic><topic>Skin Transplantation - methods</topic><topic>Skin, Artificial</topic><topic>Structural analysis</topic><topic>Surgery</topic><topic>Tissues</topic><topic>Transplant Surgery</topic><topic>Wound healing</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bondioli, Elena</creatorcontrib><creatorcontrib>Purpura, Valeria</creatorcontrib><creatorcontrib>Orlandi, Catuscia</creatorcontrib><creatorcontrib>Carboni, Andrea</creatorcontrib><creatorcontrib>Minghetti, Paola</creatorcontrib><creatorcontrib>Cenacchi, Giovanna</creatorcontrib><creatorcontrib>De Luca, Giovanni</creatorcontrib><creatorcontrib>Capirossi, Daniela</creatorcontrib><creatorcontrib>Nigrisoli, Evandro</creatorcontrib><creatorcontrib>Melandri, Davide</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cell and tissue banking</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bondioli, Elena</au><au>Purpura, Valeria</au><au>Orlandi, Catuscia</au><au>Carboni, Andrea</au><au>Minghetti, Paola</au><au>Cenacchi, Giovanna</au><au>De Luca, Giovanni</au><au>Capirossi, Daniela</au><au>Nigrisoli, Evandro</au><au>Melandri, Davide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of an acellular matrix derived from human dermis for the treatment of full-thickness skin wounds</atitle><jtitle>Cell and tissue banking</jtitle><stitle>Cell Tissue Bank</stitle><addtitle>Cell Tissue Bank</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>20</volume><issue>2</issue><spage>183</spage><epage>192</epage><pages>183-192</pages><issn>1389-9333</issn><eissn>1573-6814</eissn><abstract>Full-thickness skin wounds occur in many different clinical cases and the use of biological acellular dermal matrices (ADMs) to reconstruct the damaged area is increasing in the field of plastic and reconstructive surgery. In particular, the ability of ADMs to maintain the structural properties of extracellular matrix as well as to provide a suitable environment for cell growth makes their use suitable for the improvement of wound healing and the reduction of side effects deriving from contracture and scar tissue formation. In this study, we describe the clinical use of a recently developed human dermal matrix (HDM) in combination with graft skin as an alternative reconstructive solution for the treatment of full-thickness skin wounds. The HDM was applied in combination with autologous graft skin on three different clinical cases in which full-thickness skin wounds occurred. The clinical outcomes were evaluated in the patients during their follow-up. Histological as well as ultra-structural analysis were also performed on skin biopsy of the clinical case 3 one year after the treatment with HDM. The use of HDM stimulates the wound healing process in all clinical cases of full-thickness skin wounds here described with a functional and aesthetic rescue of the damaged area. Histological and ultra-structural analysis show a regenerative healing of the wound area with well-organized/oriented connective tissue in which cellular infiltration as well as blood vessels are evident. Our results support the clinical use of HDM as a permanent dermal replacement for the treatment of full-thickness skin wounds.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>30767153</pmid><doi>10.1007/s10561-019-09755-w</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-1272-313X</orcidid></addata></record> |
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| subjects | Acellular Dermis Autografts Biomedical and Life Sciences Biomedicine Biopsy Blood vessels Cell Biology Dermis Extracellular matrix Extracellular Matrix - physiology Humans Life Sciences Plastic surgery Reconstructive surgery Skin Skin & tissue grafts Skin - injuries Skin grafts Skin Transplantation - methods Skin, Artificial Structural analysis Surgery Tissues Transplant Surgery Wound healing Wound Healing - physiology |
| title | The use of an acellular matrix derived from human dermis for the treatment of full-thickness skin wounds |
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