Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

DNA origami nanostructures hold an immense potential to be used for biological and medical applications. However, low-salt conditions and nucleases in physiological fluids induce denaturation and degradation of self-assembled DNA nanostructures. In non-viral gene delivery, enzymatic degradation of D...

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Veröffentlicht in:	Journal of visualized experiments 2019-01 (143)
Hauptverfasser:	Ahmadi, Yasaman, Barisic, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aptamers, Nucleotide - chemistry Deoxyribonuclease I - metabolism DNA - chemistry DNA - genetics DNA - ultrastructure Genetic Therapy Horseradish Peroxidase - metabolism Nanostructures - chemistry Nanostructures - ultrastructure Nuclease Protection Assays Nucleic Acid Conformation Polyamines - chemistry
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