P62 deficiency shifts mesenchymal/stromal stem cell commitment toward adipogenesis and disrupts bone marrow homeostasis in aged mice

With advancing age have been observed bone and bone marrow phenotypic alterations due to the impaired bone tissue homeostatic features, involving bone remodeling, and bone marrow niche ontogeny. The complex “inflamm‐aging” pathological scenario that culminates with osteopenia and mesenchymal/stromal...

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Veröffentlicht in:	Journal of cellular physiology 2019-09, Vol.234 (9), p.16338-16347
Hauptverfasser:	Lacava, Giovanna, Laus, Fulvio, Amaroli, Andrea, Marchegiani, Andrea, Censi, Roberta, Di Martino, Piera, Yanagawa, Toru, Sabbieti, Maria Giovanna, Agas, Dimitrios
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Adapters Adaptor proteins Adipogenesis Aging Biocompatibility Biomedical materials bone Bone marrow bone marrow niche Bone remodeling Hematopoietic stem cells Homeostasis Inflammation Mesenchyme Ontogeny Osteopenia p62 Proteins Schedules Stem cells
Online-Zugang:	Volltext
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