Structure characterization and immunological activity of a β-glucan from White H. marmoreus and its silver nanoparticle derivatives
•A β-glucan noted as WHP was isolated from alkaline extract of white H. marmoreus.•A green method was provided for synthesis of cytotoxicity-free AgNPs with WHP.•The structure-function relationship between WHP and its derivatives were studied. White H. marmoreus is widely used as an ingredient of tr...
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| Veröffentlicht in: | Carbohydrate polymers 2019-04, Vol.210, p.1-8 |
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| creator | Zhou, Fang-Fang Zhang, Ya-Di Zhang, Qiang Lu, Jie Liu, Yong Wang, Jun-Hui |
| description | •A β-glucan noted as WHP was isolated from alkaline extract of white H. marmoreus.•A green method was provided for synthesis of cytotoxicity-free AgNPs with WHP.•The structure-function relationship between WHP and its derivatives were studied.
White H. marmoreus is widely used as an ingredient of traditional Chinese dishes. In this study, a β-glucan noted as WHP was isolated from alkaline extract of white H. marmoreus. The structure of WHP was investigated by FT-IR, NMR, methylation and partial acid hydrolysis. The results showed that the main chain of WHP was composed of (1→3)-β-D-Glcp, with an average of three to four residues of O-6 linked with 1-β-D-Glcp. Moreover, a nanoderivative (AgNPs) of WHP was prepared. The most AgNPs were synthesized when the concentration ratio of AgNO3 to WHP was 0.25. Immunological activity tests indicated that WHP had superior cell proliferation activity and its maximum proliferation index was 1.62. AgNPs could also stimulate the proliferation of macrophage RAW264.7. WHPS could better increase the phagocytosis, immunological activity of macrophage RAW264.7. The difference in immunological activity between WHP, AgNPs and WHPS evidently resulted from their structural distinction. |
| doi_str_mv | 10.1016/j.carbpol.2019.01.057 |
| format | Article |
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White H. marmoreus is widely used as an ingredient of traditional Chinese dishes. In this study, a β-glucan noted as WHP was isolated from alkaline extract of white H. marmoreus. The structure of WHP was investigated by FT-IR, NMR, methylation and partial acid hydrolysis. The results showed that the main chain of WHP was composed of (1→3)-β-D-Glcp, with an average of three to four residues of O-6 linked with 1-β-D-Glcp. Moreover, a nanoderivative (AgNPs) of WHP was prepared. The most AgNPs were synthesized when the concentration ratio of AgNO3 to WHP was 0.25. Immunological activity tests indicated that WHP had superior cell proliferation activity and its maximum proliferation index was 1.62. AgNPs could also stimulate the proliferation of macrophage RAW264.7. WHPS could better increase the phagocytosis, immunological activity of macrophage RAW264.7. The difference in immunological activity between WHP, AgNPs and WHPS evidently resulted from their structural distinction.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2019.01.057</identifier><identifier>PMID: 30732741</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Agaricales - chemistry ; Animals ; beta-Glucans - chemistry ; beta-Glucans - pharmacology ; Cell Proliferation - drug effects ; H. marmoreus ; Immunologic Factors - chemistry ; Immunologic Factors - pharmacology ; Immunological activity ; Macrophages - cytology ; Macrophages - drug effects ; Macrophages - immunology ; Macrophages - metabolism ; Metal Nanoparticles - chemistry ; Methylation ; Mice ; Nitric Oxide - biosynthesis ; Phagocytosis - drug effects ; RAW 264.7 Cells ; Silver - chemistry ; Silver nanoparticles ; Structural characterization ; β-glucan</subject><ispartof>Carbohydrate polymers, 2019-04, Vol.210, p.1-8</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-f509743a33de9346669c366627d3480aa47e6dd581510db06fd42cecae94883</citedby><cites>FETCH-LOGICAL-c365t-f509743a33de9346669c366627d3480aa47e6dd581510db06fd42cecae94883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2019.01.057$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30732741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Fang-Fang</creatorcontrib><creatorcontrib>Zhang, Ya-Di</creatorcontrib><creatorcontrib>Zhang, Qiang</creatorcontrib><creatorcontrib>Lu, Jie</creatorcontrib><creatorcontrib>Liu, Yong</creatorcontrib><creatorcontrib>Wang, Jun-Hui</creatorcontrib><title>Structure characterization and immunological activity of a β-glucan from White H. marmoreus and its silver nanoparticle derivatives</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>•A β-glucan noted as WHP was isolated from alkaline extract of white H. marmoreus.•A green method was provided for synthesis of cytotoxicity-free AgNPs with WHP.•The structure-function relationship between WHP and its derivatives were studied.
White H. marmoreus is widely used as an ingredient of traditional Chinese dishes. In this study, a β-glucan noted as WHP was isolated from alkaline extract of white H. marmoreus. The structure of WHP was investigated by FT-IR, NMR, methylation and partial acid hydrolysis. The results showed that the main chain of WHP was composed of (1→3)-β-D-Glcp, with an average of three to four residues of O-6 linked with 1-β-D-Glcp. Moreover, a nanoderivative (AgNPs) of WHP was prepared. The most AgNPs were synthesized when the concentration ratio of AgNO3 to WHP was 0.25. Immunological activity tests indicated that WHP had superior cell proliferation activity and its maximum proliferation index was 1.62. AgNPs could also stimulate the proliferation of macrophage RAW264.7. WHPS could better increase the phagocytosis, immunological activity of macrophage RAW264.7. The difference in immunological activity between WHP, AgNPs and WHPS evidently resulted from their structural distinction.</description><subject>Agaricales - chemistry</subject><subject>Animals</subject><subject>beta-Glucans - chemistry</subject><subject>beta-Glucans - pharmacology</subject><subject>Cell Proliferation - drug effects</subject><subject>H. marmoreus</subject><subject>Immunologic Factors - chemistry</subject><subject>Immunologic Factors - pharmacology</subject><subject>Immunological activity</subject><subject>Macrophages - cytology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - immunology</subject><subject>Macrophages - metabolism</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Methylation</subject><subject>Mice</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Phagocytosis - drug effects</subject><subject>RAW 264.7 Cells</subject><subject>Silver - chemistry</subject><subject>Silver nanoparticles</subject><subject>Structural characterization</subject><subject>β-glucan</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu1DAQhi1ERbeFRwD5yCXBjh0nOSFUFYpUqYcicbRm7UnrlRMvthOpPfNEPEifCVe7cO1c5jD__L_-j5D3nNWccfVpVxuI233wdcP4UDNes7Z7RTa874aKCylfkw3jUla94t0pOUtpx8oozt6QU8E60XSSb8jv2xwXk5eI1NxDBJMxukfILswUZkvdNC1z8OHOGfC0nN3q8gMNIwX69Ke684uBmY4xTPTnvctIr2o6QZxCxCUdHHKiyfkVI51hDnuI2RmP1JagtQStmN6SkxF8wnfHfU5uv17-uLiqrm--fb_4cl0ZodpcjS0bOilACIuDkEqpoRyUajorZM8AZIfK2rbnLWd2y9RoZWPQAA6y78U5-Xhw3cfwa8GU9eSSQe9hxrAk3TTNwIam2BVpe5CaGFKKOOp9dKXWg-ZMP-PXO33Er5_xa8Z1wV_-Phwjlu2E9v_XP95F8PkgwFJzdRh1Mg5ng9ZFNFnb4F6I-AvBpZwt</recordid><startdate>20190415</startdate><enddate>20190415</enddate><creator>Zhou, Fang-Fang</creator><creator>Zhang, Ya-Di</creator><creator>Zhang, Qiang</creator><creator>Lu, Jie</creator><creator>Liu, Yong</creator><creator>Wang, Jun-Hui</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190415</creationdate><title>Structure characterization and immunological activity of a β-glucan from White H. marmoreus and its silver nanoparticle derivatives</title><author>Zhou, Fang-Fang ; Zhang, Ya-Di ; Zhang, Qiang ; Lu, Jie ; Liu, Yong ; Wang, Jun-Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-f509743a33de9346669c366627d3480aa47e6dd581510db06fd42cecae94883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Agaricales - chemistry</topic><topic>Animals</topic><topic>beta-Glucans - chemistry</topic><topic>beta-Glucans - pharmacology</topic><topic>Cell Proliferation - drug effects</topic><topic>H. marmoreus</topic><topic>Immunologic Factors - chemistry</topic><topic>Immunologic Factors - pharmacology</topic><topic>Immunological activity</topic><topic>Macrophages - cytology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - immunology</topic><topic>Macrophages - metabolism</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Methylation</topic><topic>Mice</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Phagocytosis - drug effects</topic><topic>RAW 264.7 Cells</topic><topic>Silver - chemistry</topic><topic>Silver nanoparticles</topic><topic>Structural characterization</topic><topic>β-glucan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Fang-Fang</creatorcontrib><creatorcontrib>Zhang, Ya-Di</creatorcontrib><creatorcontrib>Zhang, Qiang</creatorcontrib><creatorcontrib>Lu, Jie</creatorcontrib><creatorcontrib>Liu, Yong</creatorcontrib><creatorcontrib>Wang, Jun-Hui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Fang-Fang</au><au>Zhang, Ya-Di</au><au>Zhang, Qiang</au><au>Lu, Jie</au><au>Liu, Yong</au><au>Wang, Jun-Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure characterization and immunological activity of a β-glucan from White H. marmoreus and its silver nanoparticle derivatives</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2019-04-15</date><risdate>2019</risdate><volume>210</volume><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><abstract>•A β-glucan noted as WHP was isolated from alkaline extract of white H. marmoreus.•A green method was provided for synthesis of cytotoxicity-free AgNPs with WHP.•The structure-function relationship between WHP and its derivatives were studied.
White H. marmoreus is widely used as an ingredient of traditional Chinese dishes. In this study, a β-glucan noted as WHP was isolated from alkaline extract of white H. marmoreus. The structure of WHP was investigated by FT-IR, NMR, methylation and partial acid hydrolysis. The results showed that the main chain of WHP was composed of (1→3)-β-D-Glcp, with an average of three to four residues of O-6 linked with 1-β-D-Glcp. Moreover, a nanoderivative (AgNPs) of WHP was prepared. The most AgNPs were synthesized when the concentration ratio of AgNO3 to WHP was 0.25. Immunological activity tests indicated that WHP had superior cell proliferation activity and its maximum proliferation index was 1.62. AgNPs could also stimulate the proliferation of macrophage RAW264.7. WHPS could better increase the phagocytosis, immunological activity of macrophage RAW264.7. The difference in immunological activity between WHP, AgNPs and WHPS evidently resulted from their structural distinction.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30732741</pmid><doi>10.1016/j.carbpol.2019.01.057</doi><tpages>8</tpages></addata></record> |
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| subjects | Agaricales - chemistry Animals beta-Glucans - chemistry beta-Glucans - pharmacology Cell Proliferation - drug effects H. marmoreus Immunologic Factors - chemistry Immunologic Factors - pharmacology Immunological activity Macrophages - cytology Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Metal Nanoparticles - chemistry Methylation Mice Nitric Oxide - biosynthesis Phagocytosis - drug effects RAW 264.7 Cells Silver - chemistry Silver nanoparticles Structural characterization β-glucan |
| title | Structure characterization and immunological activity of a β-glucan from White H. marmoreus and its silver nanoparticle derivatives |
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