Preoperative CA125 value predicts Glisson capsule involvement in patients with peritoneal carcinomatosis undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
The difficulty of detecting lesions smaller than 1 cm in the preoperative period is still a continuing problem in peritoneal carcinomatosis. The prospective data of 106 peritoneal carcinomatosis patients were included this study. Preoperative AFP, carcinoembryonic antigen, CA19.9, CA125, neutrophil/...
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| Veröffentlicht in: | Biomarkers in medicine 2019-04, Vol.13 (5), p.359-369 |
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| creator | Duzgun, Ozgul Sarici, Inanc Samil |
| description | The difficulty of detecting lesions smaller than 1 cm in the preoperative period is still a continuing problem in peritoneal carcinomatosis.
The prospective data of 106 peritoneal carcinomatosis patients were included this study. Preoperative AFP, carcinoembryonic antigen, CA19.9, CA125, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet value, platelet distribution width, red cell distribution width and radiological findings compared according to Glisson capsule tumor involvement.
Preoperative radiological imaging methods have low accuracy in demonstrating Glisson capsule involvement. Inflammatory and serum tumor markers, except CA125, have been shown to be ineffective at detecting preoperative Glisson capsule involvement. CA125 levels higher than 52.4 were found to be significant in indicating Glisson's capsule involvement.
CA125 is more sensitive than radiological and nuclear imaging methods in detecting tumors smaller than 1 cm. |
| doi_str_mv | 10.2217/bmm-2019-0009 |
| format | Article |
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The prospective data of 106 peritoneal carcinomatosis patients were included this study. Preoperative AFP, carcinoembryonic antigen, CA19.9, CA125, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet value, platelet distribution width, red cell distribution width and radiological findings compared according to Glisson capsule tumor involvement.
Preoperative radiological imaging methods have low accuracy in demonstrating Glisson capsule involvement. Inflammatory and serum tumor markers, except CA125, have been shown to be ineffective at detecting preoperative Glisson capsule involvement. CA125 levels higher than 52.4 were found to be significant in indicating Glisson's capsule involvement.
CA125 is more sensitive than radiological and nuclear imaging methods in detecting tumors smaller than 1 cm.</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2019-0009</identifier><identifier>PMID: 30758236</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Abdomen ; Adult ; Aged ; Aged, 80 and over ; Biomarkers ; CA-125 Antigen - blood ; CA125 ; Carcinoembryonic antigen ; CEA ; Chemotherapy ; Colorectal cancer ; Cytoreduction Surgical Procedures ; cytoreductive surgery ; Diagnostic Imaging ; Female ; Gastric cancer ; Glisson capsule ; Humans ; Hyperthermia, Induced ; hyperthermic intraperitoneal chemotherapy (HIPEC) ; Inflammation ; Liver - diagnostic imaging ; Liver - pathology ; Male ; Medical prognosis ; Mesothelioma ; Middle Aged ; neutrophil/lymphocyte ratio ; NMR ; Nuclear magnetic resonance ; Ovarian cancer ; Peritoneal Neoplasms - blood ; Peritoneal Neoplasms - diagnostic imaging ; Peritoneal Neoplasms - pathology ; Peritoneal Neoplasms - therapy ; Peritoneum ; platelet/lymphocyte ratio ; Platelets ; Preoperative Period ; ROC Curve ; Studies ; Surgery ; Tumor Burden ; Tumor markers ; Tumors</subject><ispartof>Biomarkers in medicine, 2019-04, Vol.13 (5), p.359-369</ispartof><rights>2019 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Apr 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-2a106ef04ca6336688f7c0628403f8470599830f48b97cde17be5dad989a3a13</citedby><cites>FETCH-LOGICAL-c371t-2a106ef04ca6336688f7c0628403f8470599830f48b97cde17be5dad989a3a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30758236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duzgun, Ozgul</creatorcontrib><creatorcontrib>Sarici, Inanc Samil</creatorcontrib><title>Preoperative CA125 value predicts Glisson capsule involvement in patients with peritoneal carcinomatosis undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy</title><title>Biomarkers in medicine</title><addtitle>Biomark Med</addtitle><description>The difficulty of detecting lesions smaller than 1 cm in the preoperative period is still a continuing problem in peritoneal carcinomatosis.
The prospective data of 106 peritoneal carcinomatosis patients were included this study. Preoperative AFP, carcinoembryonic antigen, CA19.9, CA125, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet value, platelet distribution width, red cell distribution width and radiological findings compared according to Glisson capsule tumor involvement.
Preoperative radiological imaging methods have low accuracy in demonstrating Glisson capsule involvement. Inflammatory and serum tumor markers, except CA125, have been shown to be ineffective at detecting preoperative Glisson capsule involvement. CA125 levels higher than 52.4 were found to be significant in indicating Glisson's capsule involvement.
CA125 is more sensitive than radiological and nuclear imaging methods in detecting tumors smaller than 1 cm.</description><subject>Abdomen</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers</subject><subject>CA-125 Antigen - blood</subject><subject>CA125</subject><subject>Carcinoembryonic antigen</subject><subject>CEA</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Cytoreduction Surgical Procedures</subject><subject>cytoreductive surgery</subject><subject>Diagnostic Imaging</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Glisson capsule</subject><subject>Humans</subject><subject>Hyperthermia, Induced</subject><subject>hyperthermic intraperitoneal chemotherapy (HIPEC)</subject><subject>Inflammation</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Mesothelioma</subject><subject>Middle Aged</subject><subject>neutrophil/lymphocyte ratio</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Ovarian cancer</subject><subject>Peritoneal Neoplasms - blood</subject><subject>Peritoneal Neoplasms - diagnostic imaging</subject><subject>Peritoneal Neoplasms - pathology</subject><subject>Peritoneal Neoplasms - therapy</subject><subject>Peritoneum</subject><subject>platelet/lymphocyte ratio</subject><subject>Platelets</subject><subject>Preoperative Period</subject><subject>ROC Curve</subject><subject>Studies</subject><subject>Surgery</subject><subject>Tumor Burden</subject><subject>Tumor markers</subject><subject>Tumors</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU2L1DAYgIso7rp69CoBL16q-WiT5rgMugoLeth7yKRvZ7I0Sc3HSH-Zf8_UWRcRPPUtefIk5Gma1wS_p5SID3vnWoqJbDHG8klzSURPW8wEefo4c3bRvEjpHuNeCE6fNxcMi36gjF82P79FCAtEne0J0O6a0B6d9FwALRFGa3JCN7NNKXhk9JLKDMj6U5hP4MDnOqOlbq1jQj9sPqKqsjl40HPlo7E-OJ1DsgkVP0I8BOsPyKw5VHsxvw9NJR4grkj7ER3XKshHiM6aKs9R_y08ggvbol7Wl82zSc8JXj18r5q7Tx_vdp_b2683X3bXt62pT5BbqgnmMOHOaM4Y58MwCYM5HTrMpqETuJdyYHjqhr0UZgQi9tCPepSD1EwTdtW8O2uXGL4XSFk5mwzMs_YQSlKUUokloZ2o6Nt_0PtQoq-Xq5TgtY6QG9WeKRNDShEmtUTrdFwVwWoLqmpQtQVVW9DKv3mwlr2D8ZH-U7AC8gxMJZcIydQYBtT5z20JrYf_yH8B0IC0xQ</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Duzgun, Ozgul</creator><creator>Sarici, Inanc Samil</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190401</creationdate><title>Preoperative CA125 value predicts Glisson capsule involvement in patients with peritoneal carcinomatosis undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy</title><author>Duzgun, Ozgul ; Sarici, Inanc Samil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-2a106ef04ca6336688f7c0628403f8470599830f48b97cde17be5dad989a3a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdomen</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers</topic><topic>CA-125 Antigen - blood</topic><topic>CA125</topic><topic>Carcinoembryonic antigen</topic><topic>CEA</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Cytoreduction Surgical Procedures</topic><topic>cytoreductive surgery</topic><topic>Diagnostic Imaging</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Glisson capsule</topic><topic>Humans</topic><topic>Hyperthermia, Induced</topic><topic>hyperthermic intraperitoneal chemotherapy (HIPEC)</topic><topic>Inflammation</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Mesothelioma</topic><topic>Middle Aged</topic><topic>neutrophil/lymphocyte ratio</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Ovarian cancer</topic><topic>Peritoneal Neoplasms - blood</topic><topic>Peritoneal Neoplasms - diagnostic imaging</topic><topic>Peritoneal Neoplasms - pathology</topic><topic>Peritoneal Neoplasms - therapy</topic><topic>Peritoneum</topic><topic>platelet/lymphocyte ratio</topic><topic>Platelets</topic><topic>Preoperative Period</topic><topic>ROC Curve</topic><topic>Studies</topic><topic>Surgery</topic><topic>Tumor Burden</topic><topic>Tumor markers</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duzgun, Ozgul</creatorcontrib><creatorcontrib>Sarici, Inanc Samil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duzgun, Ozgul</au><au>Sarici, Inanc Samil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative CA125 value predicts Glisson capsule involvement in patients with peritoneal carcinomatosis undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>13</volume><issue>5</issue><spage>359</spage><epage>369</epage><pages>359-369</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>The difficulty of detecting lesions smaller than 1 cm in the preoperative period is still a continuing problem in peritoneal carcinomatosis.
The prospective data of 106 peritoneal carcinomatosis patients were included this study. Preoperative AFP, carcinoembryonic antigen, CA19.9, CA125, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet value, platelet distribution width, red cell distribution width and radiological findings compared according to Glisson capsule tumor involvement.
Preoperative radiological imaging methods have low accuracy in demonstrating Glisson capsule involvement. Inflammatory and serum tumor markers, except CA125, have been shown to be ineffective at detecting preoperative Glisson capsule involvement. CA125 levels higher than 52.4 were found to be significant in indicating Glisson's capsule involvement.
CA125 is more sensitive than radiological and nuclear imaging methods in detecting tumors smaller than 1 cm.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>30758236</pmid><doi>10.2217/bmm-2019-0009</doi><tpages>11</tpages></addata></record> |
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| subjects | Abdomen Adult Aged Aged, 80 and over Biomarkers CA-125 Antigen - blood CA125 Carcinoembryonic antigen CEA Chemotherapy Colorectal cancer Cytoreduction Surgical Procedures cytoreductive surgery Diagnostic Imaging Female Gastric cancer Glisson capsule Humans Hyperthermia, Induced hyperthermic intraperitoneal chemotherapy (HIPEC) Inflammation Liver - diagnostic imaging Liver - pathology Male Medical prognosis Mesothelioma Middle Aged neutrophil/lymphocyte ratio NMR Nuclear magnetic resonance Ovarian cancer Peritoneal Neoplasms - blood Peritoneal Neoplasms - diagnostic imaging Peritoneal Neoplasms - pathology Peritoneal Neoplasms - therapy Peritoneum platelet/lymphocyte ratio Platelets Preoperative Period ROC Curve Studies Surgery Tumor Burden Tumor markers Tumors |
| title | Preoperative CA125 value predicts Glisson capsule involvement in patients with peritoneal carcinomatosis undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy |
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