DNA methylation profiling reliably distinguishes pulmonary enteric adenocarcinoma from metastatic colorectal cancer

Pulmonary enteric adenocarcinoma is a rare non-small cell lung cancer subtype. It is poorly characterized and cannot be distinguished from metastatic colorectal or upper gastrointestinal adenocarcinomas by means of routine pathological methods. As DNA methylation patterns are known to be highly tiss...

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Veröffentlicht in:	Modern pathology 2019-06, Vol.32 (6), p.855-865
Hauptverfasser:	Jurmeister, Philipp, Schöler, Anne, Arnold, Alexander, Klauschen, Frederick, Lenze, Dido, Hummel, Michael, Schweizer, Leonille, Bläker, Hendrik, Pfitzner, Berit Maria, Mamlouk, Soulafa, Sers, Christine, Denkert, Carsten, Stichel, Damian, Frost, Nikolaj, Horst, David, von Laffert, Maximilian, Capper, David
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/32 14/63 45/23 631/1647/2210/2213 631/67/1612/1350 631/67/68/2486 692/699/67/1612/1350 692/699/67/68/2486 Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - genetics Adenocarcinoma - secondary Adenocarcinoma of Lung - diagnosis Adenocarcinoma of Lung - genetics Aged Algorithms Artificial intelligence Chromosome 20 Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Copy number Deoxyribonucleic acid DNA DNA fingerprinting DNA Methylation Embedding Female Fluorescence in situ hybridization Gene expression Gene Expression Profiling - methods Genomes Humans Laboratory Medicine Learning algorithms Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Machine Learning Male Medicine Medicine & Public Health Metastases Metastasis Middle Aged Neoplasm Metastasis - genetics Next-generation sequencing Non-small cell lung carcinoma Pathology Stochasticity Tumors
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