Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin’s lymphoma: a nationwide population-based study

Abstract Objectives We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship between SLE and non-Hodgkin’s lymphoma (NHL). Methods Using the National Health Insurance Research Database of Taiwan, we identified 16 417 patients with new...

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Veröffentlicht in:Rheumatology (Oxford, England) England), 2019-07, Vol.58 (7), p.1245-1249
Hauptverfasser: Wang, Li-Hui, Wang, Wei-Ming, Lin, Sheng-Hsiang, Shieh, Chi-Chang
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creator Wang, Li-Hui
Wang, Wei-Ming
Lin, Sheng-Hsiang
Shieh, Chi-Chang
description Abstract Objectives We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship between SLE and non-Hodgkin’s lymphoma (NHL). Methods Using the National Health Insurance Research Database of Taiwan, we identified 16 417 patients with new-onset SLE without previous cancer and 25 069 patients with new-onset NHL without previous SLE as two non-overlapping cohorts from 1998–2012, and followed them until 2013. Standardized incidence ratio (SIR) for NHL in the patients with SLE and SIR for SLE in the patients with NHL were compared with the general population. Results Among the 16 417 patients with SLE, 512 developed cancers, including 34 with NHL. The highest SIR was that for NHL (SIR 4.2, 95% CI 2.9, 5.9) in site-specific cancer risk analysis. Among the 25 069 patients with NHL, 14 developed SLE, and the SIR was also increased (SIR 2.0, 95% CI 1.1, 3.4). The SIRs of the patients with SLE to develop NHL and the patients with NHL to develop SLE were both highest within the first year after the diagnosis of each disease. Conclusion This nationwide population-based study is the first study to report a bidirectional relationship between SLE and NHL. This finding may suggest being alert for the patients with SLE or NHL who have early sings of the other disease in clinical care.
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Methods Using the National Health Insurance Research Database of Taiwan, we identified 16 417 patients with new-onset SLE without previous cancer and 25 069 patients with new-onset NHL without previous SLE as two non-overlapping cohorts from 1998–2012, and followed them until 2013. Standardized incidence ratio (SIR) for NHL in the patients with SLE and SIR for SLE in the patients with NHL were compared with the general population. Results Among the 16 417 patients with SLE, 512 developed cancers, including 34 with NHL. The highest SIR was that for NHL (SIR 4.2, 95% CI 2.9, 5.9) in site-specific cancer risk analysis. Among the 25 069 patients with NHL, 14 developed SLE, and the SIR was also increased (SIR 2.0, 95% CI 1.1, 3.4). The SIRs of the patients with SLE to develop NHL and the patients with NHL to develop SLE were both highest within the first year after the diagnosis of each disease. Conclusion This nationwide population-based study is the first study to report a bidirectional relationship between SLE and NHL. This finding may suggest being alert for the patients with SLE or NHL who have early sings of the other disease in clinical care.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/kez011</identifier><identifier>PMID: 30726952</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adolescent ; Adult ; Child ; Cohort Studies ; Databases, Factual ; Female ; Follow-Up Studies ; Humans ; Incidence ; Lupus ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - epidemiology ; Lymphoma ; Lymphoma, Non-Hodgkin - complications ; Lymphoma, Non-Hodgkin - epidemiology ; Male ; Middle Aged ; Non-Hodgkin's lymphoma ; Population ; Population studies ; Population-based studies ; Risk Assessment - methods ; Systemic lupus erythematosus ; Taiwan - epidemiology ; Young Adult</subject><ispartof>Rheumatology (Oxford, England), 2019-07, Vol.58 (7), p.1245-1249</ispartof><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-2f59d90bda6b5f5005dc16734d868060204f7c6a6baf2ced75891c0bd91a65cd3</citedby><cites>FETCH-LOGICAL-c438t-2f59d90bda6b5f5005dc16734d868060204f7c6a6baf2ced75891c0bd91a65cd3</cites><orcidid>0000-0001-6634-6862</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,1586,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30726952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Li-Hui</creatorcontrib><creatorcontrib>Wang, Wei-Ming</creatorcontrib><creatorcontrib>Lin, Sheng-Hsiang</creatorcontrib><creatorcontrib>Shieh, Chi-Chang</creatorcontrib><title>Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin’s lymphoma: a nationwide population-based study</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>Abstract Objectives We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship between SLE and non-Hodgkin’s lymphoma (NHL). Methods Using the National Health Insurance Research Database of Taiwan, we identified 16 417 patients with new-onset SLE without previous cancer and 25 069 patients with new-onset NHL without previous SLE as two non-overlapping cohorts from 1998–2012, and followed them until 2013. Standardized incidence ratio (SIR) for NHL in the patients with SLE and SIR for SLE in the patients with NHL were compared with the general population. Results Among the 16 417 patients with SLE, 512 developed cancers, including 34 with NHL. The highest SIR was that for NHL (SIR 4.2, 95% CI 2.9, 5.9) in site-specific cancer risk analysis. Among the 25 069 patients with NHL, 14 developed SLE, and the SIR was also increased (SIR 2.0, 95% CI 1.1, 3.4). The SIRs of the patients with SLE to develop NHL and the patients with NHL to develop SLE were both highest within the first year after the diagnosis of each disease. Conclusion This nationwide population-based study is the first study to report a bidirectional relationship between SLE and NHL. This finding may suggest being alert for the patients with SLE or NHL who have early sings of the other disease in clinical care.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - epidemiology</subject><subject>Lymphoma</subject><subject>Lymphoma, Non-Hodgkin - complications</subject><subject>Lymphoma, Non-Hodgkin - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-Hodgkin's lymphoma</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Risk Assessment - methods</subject><subject>Systemic lupus erythematosus</subject><subject>Taiwan - epidemiology</subject><subject>Young Adult</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1O3TAQRq0KVCjtE1RClth0E_BPnMTdASoFCYkNXUeOPeEakjjYsa7SFTxGX48nqW8DqGLFymPNmWN5PoS-UnJIieRHfgWxV5Pr3M18dAe_CaUf0C7NC5YRztnWa83yHfQphFtCiKC8-oh2OClZIQXbRY8n1lgPerJuUB320KlNGVZ2xA1Ma4ABhzlM0FuNuzjGgMHP0wo2L4d0U4PBgxuyc2du7uzw9PAn4G7ux5Xr1Xes8PDPt7YG8OjGuOizRgUwOEzRzJ_Rdqu6AF-ezz306-zH9el5dnn18-L0-DLTOa-mjLVCGkkao4pGtCJ9xWhalDw3VVGRgjCSt6UuUle1TIMpRSWpTrykqhDa8D30bfGO3t1HCFPd26Ch69QALoaaMSZJlRMpEnrwBr110af9JCovc8mokDJRfKG0dyF4aOvR2175uaak3iRU_59QvSSUpvaf3bHpwbzOvESSgMMFcHF8l_Ev7h2mKw</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Wang, Li-Hui</creator><creator>Wang, Wei-Ming</creator><creator>Lin, Sheng-Hsiang</creator><creator>Shieh, Chi-Chang</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6634-6862</orcidid></search><sort><creationdate>20190701</creationdate><title>Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin’s lymphoma: a nationwide population-based study</title><author>Wang, Li-Hui ; Wang, Wei-Ming ; Lin, Sheng-Hsiang ; Shieh, Chi-Chang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-2f59d90bda6b5f5005dc16734d868060204f7c6a6baf2ced75891c0bd91a65cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - epidemiology</topic><topic>Lymphoma</topic><topic>Lymphoma, Non-Hodgkin - complications</topic><topic>Lymphoma, Non-Hodgkin - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Non-Hodgkin's lymphoma</topic><topic>Population</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Risk Assessment - methods</topic><topic>Systemic lupus erythematosus</topic><topic>Taiwan - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Li-Hui</creatorcontrib><creatorcontrib>Wang, Wei-Ming</creatorcontrib><creatorcontrib>Lin, Sheng-Hsiang</creatorcontrib><creatorcontrib>Shieh, Chi-Chang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Li-Hui</au><au>Wang, Wei-Ming</au><au>Lin, Sheng-Hsiang</au><au>Shieh, Chi-Chang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin’s lymphoma: a nationwide population-based study</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>58</volume><issue>7</issue><spage>1245</spage><epage>1249</epage><pages>1245-1249</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><abstract>Abstract Objectives We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship between SLE and non-Hodgkin’s lymphoma (NHL). Methods Using the National Health Insurance Research Database of Taiwan, we identified 16 417 patients with new-onset SLE without previous cancer and 25 069 patients with new-onset NHL without previous SLE as two non-overlapping cohorts from 1998–2012, and followed them until 2013. Standardized incidence ratio (SIR) for NHL in the patients with SLE and SIR for SLE in the patients with NHL were compared with the general population. Results Among the 16 417 patients with SLE, 512 developed cancers, including 34 with NHL. The highest SIR was that for NHL (SIR 4.2, 95% CI 2.9, 5.9) in site-specific cancer risk analysis. Among the 25 069 patients with NHL, 14 developed SLE, and the SIR was also increased (SIR 2.0, 95% CI 1.1, 3.4). The SIRs of the patients with SLE to develop NHL and the patients with NHL to develop SLE were both highest within the first year after the diagnosis of each disease. Conclusion This nationwide population-based study is the first study to report a bidirectional relationship between SLE and NHL. This finding may suggest being alert for the patients with SLE or NHL who have early sings of the other disease in clinical care.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>30726952</pmid><doi>10.1093/rheumatology/kez011</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-6634-6862</orcidid></addata></record>
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subjects Adolescent
Adult
Child
Cohort Studies
Databases, Factual
Female
Follow-Up Studies
Humans
Incidence
Lupus
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - epidemiology
Lymphoma
Lymphoma, Non-Hodgkin - complications
Lymphoma, Non-Hodgkin - epidemiology
Male
Middle Aged
Non-Hodgkin's lymphoma
Population
Population studies
Population-based studies
Risk Assessment - methods
Systemic lupus erythematosus
Taiwan - epidemiology
Young Adult
title Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin’s lymphoma: a nationwide population-based study
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