Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin’s lymphoma: a nationwide population-based study
Abstract Objectives We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship between SLE and non-Hodgkin’s lymphoma (NHL). Methods Using the National Health Insurance Research Database of Taiwan, we identified 16 417 patients with new...
Gespeichert in:
| Veröffentlicht in: | Rheumatology (Oxford, England) England), 2019-07, Vol.58 (7), p.1245-1249 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1249 |
|---|---|
| container_issue | 7 |
| container_start_page | 1245 |
| container_title | Rheumatology (Oxford, England) |
| container_volume | 58 |
| creator | Wang, Li-Hui Wang, Wei-Ming Lin, Sheng-Hsiang Shieh, Chi-Chang |
| description | Abstract
Objectives
We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship between SLE and non-Hodgkin’s lymphoma (NHL).
Methods
Using the National Health Insurance Research Database of Taiwan, we identified 16 417 patients with new-onset SLE without previous cancer and 25 069 patients with new-onset NHL without previous SLE as two non-overlapping cohorts from 1998–2012, and followed them until 2013. Standardized incidence ratio (SIR) for NHL in the patients with SLE and SIR for SLE in the patients with NHL were compared with the general population.
Results
Among the 16 417 patients with SLE, 512 developed cancers, including 34 with NHL. The highest SIR was that for NHL (SIR 4.2, 95% CI 2.9, 5.9) in site-specific cancer risk analysis. Among the 25 069 patients with NHL, 14 developed SLE, and the SIR was also increased (SIR 2.0, 95% CI 1.1, 3.4). The SIRs of the patients with SLE to develop NHL and the patients with NHL to develop SLE were both highest within the first year after the diagnosis of each disease.
Conclusion
This nationwide population-based study is the first study to report a bidirectional relationship between SLE and NHL. This finding may suggest being alert for the patients with SLE or NHL who have early sings of the other disease in clinical care. |
| doi_str_mv | 10.1093/rheumatology/kez011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2229084095</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/rheumatology/kez011</oup_id><sourcerecordid>2229084095</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-2f59d90bda6b5f5005dc16734d868060204f7c6a6baf2ced75891c0bd91a65cd3</originalsourceid><addsrcrecordid>eNqNkc1O3TAQRq0KVCjtE1RClth0E_BPnMTdASoFCYkNXUeOPeEakjjYsa7SFTxGX48nqW8DqGLFymPNmWN5PoS-UnJIieRHfgWxV5Pr3M18dAe_CaUf0C7NC5YRztnWa83yHfQphFtCiKC8-oh2OClZIQXbRY8n1lgPerJuUB320KlNGVZ2xA1Ma4ABhzlM0FuNuzjGgMHP0wo2L4d0U4PBgxuyc2du7uzw9PAn4G7ux5Xr1Xes8PDPt7YG8OjGuOizRgUwOEzRzJ_Rdqu6AF-ezz306-zH9el5dnn18-L0-DLTOa-mjLVCGkkao4pGtCJ9xWhalDw3VVGRgjCSt6UuUle1TIMpRSWpTrykqhDa8D30bfGO3t1HCFPd26Ch69QALoaaMSZJlRMpEnrwBr110af9JCovc8mokDJRfKG0dyF4aOvR2175uaak3iRU_59QvSSUpvaf3bHpwbzOvESSgMMFcHF8l_Ev7h2mKw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2474921599</pqid></control><display><type>article</type><title>Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin’s lymphoma: a nationwide population-based study</title><source>MEDLINE</source><source>Oxford University Press Journals</source><source>Alma/SFX Local Collection</source><creator>Wang, Li-Hui ; Wang, Wei-Ming ; Lin, Sheng-Hsiang ; Shieh, Chi-Chang</creator><creatorcontrib>Wang, Li-Hui ; Wang, Wei-Ming ; Lin, Sheng-Hsiang ; Shieh, Chi-Chang</creatorcontrib><description>Abstract
Objectives
We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship between SLE and non-Hodgkin’s lymphoma (NHL).
Methods
Using the National Health Insurance Research Database of Taiwan, we identified 16 417 patients with new-onset SLE without previous cancer and 25 069 patients with new-onset NHL without previous SLE as two non-overlapping cohorts from 1998–2012, and followed them until 2013. Standardized incidence ratio (SIR) for NHL in the patients with SLE and SIR for SLE in the patients with NHL were compared with the general population.
Results
Among the 16 417 patients with SLE, 512 developed cancers, including 34 with NHL. The highest SIR was that for NHL (SIR 4.2, 95% CI 2.9, 5.9) in site-specific cancer risk analysis. Among the 25 069 patients with NHL, 14 developed SLE, and the SIR was also increased (SIR 2.0, 95% CI 1.1, 3.4). The SIRs of the patients with SLE to develop NHL and the patients with NHL to develop SLE were both highest within the first year after the diagnosis of each disease.
Conclusion
This nationwide population-based study is the first study to report a bidirectional relationship between SLE and NHL. This finding may suggest being alert for the patients with SLE or NHL who have early sings of the other disease in clinical care.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/kez011</identifier><identifier>PMID: 30726952</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adolescent ; Adult ; Child ; Cohort Studies ; Databases, Factual ; Female ; Follow-Up Studies ; Humans ; Incidence ; Lupus ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - epidemiology ; Lymphoma ; Lymphoma, Non-Hodgkin - complications ; Lymphoma, Non-Hodgkin - epidemiology ; Male ; Middle Aged ; Non-Hodgkin's lymphoma ; Population ; Population studies ; Population-based studies ; Risk Assessment - methods ; Systemic lupus erythematosus ; Taiwan - epidemiology ; Young Adult</subject><ispartof>Rheumatology (Oxford, England), 2019-07, Vol.58 (7), p.1245-1249</ispartof><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com 2019</rights><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-2f59d90bda6b5f5005dc16734d868060204f7c6a6baf2ced75891c0bd91a65cd3</citedby><cites>FETCH-LOGICAL-c438t-2f59d90bda6b5f5005dc16734d868060204f7c6a6baf2ced75891c0bd91a65cd3</cites><orcidid>0000-0001-6634-6862</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,1586,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30726952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Li-Hui</creatorcontrib><creatorcontrib>Wang, Wei-Ming</creatorcontrib><creatorcontrib>Lin, Sheng-Hsiang</creatorcontrib><creatorcontrib>Shieh, Chi-Chang</creatorcontrib><title>Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin’s lymphoma: a nationwide population-based study</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>Abstract
Objectives
We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship between SLE and non-Hodgkin’s lymphoma (NHL).
Methods
Using the National Health Insurance Research Database of Taiwan, we identified 16 417 patients with new-onset SLE without previous cancer and 25 069 patients with new-onset NHL without previous SLE as two non-overlapping cohorts from 1998–2012, and followed them until 2013. Standardized incidence ratio (SIR) for NHL in the patients with SLE and SIR for SLE in the patients with NHL were compared with the general population.
Results
Among the 16 417 patients with SLE, 512 developed cancers, including 34 with NHL. The highest SIR was that for NHL (SIR 4.2, 95% CI 2.9, 5.9) in site-specific cancer risk analysis. Among the 25 069 patients with NHL, 14 developed SLE, and the SIR was also increased (SIR 2.0, 95% CI 1.1, 3.4). The SIRs of the patients with SLE to develop NHL and the patients with NHL to develop SLE were both highest within the first year after the diagnosis of each disease.
Conclusion
This nationwide population-based study is the first study to report a bidirectional relationship between SLE and NHL. This finding may suggest being alert for the patients with SLE or NHL who have early sings of the other disease in clinical care.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - epidemiology</subject><subject>Lymphoma</subject><subject>Lymphoma, Non-Hodgkin - complications</subject><subject>Lymphoma, Non-Hodgkin - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-Hodgkin's lymphoma</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Risk Assessment - methods</subject><subject>Systemic lupus erythematosus</subject><subject>Taiwan - epidemiology</subject><subject>Young Adult</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1O3TAQRq0KVCjtE1RClth0E_BPnMTdASoFCYkNXUeOPeEakjjYsa7SFTxGX48nqW8DqGLFymPNmWN5PoS-UnJIieRHfgWxV5Pr3M18dAe_CaUf0C7NC5YRztnWa83yHfQphFtCiKC8-oh2OClZIQXbRY8n1lgPerJuUB320KlNGVZ2xA1Ma4ABhzlM0FuNuzjGgMHP0wo2L4d0U4PBgxuyc2du7uzw9PAn4G7ux5Xr1Xes8PDPt7YG8OjGuOizRgUwOEzRzJ_Rdqu6AF-ezz306-zH9el5dnn18-L0-DLTOa-mjLVCGkkao4pGtCJ9xWhalDw3VVGRgjCSt6UuUle1TIMpRSWpTrykqhDa8D30bfGO3t1HCFPd26Ch69QALoaaMSZJlRMpEnrwBr110af9JCovc8mokDJRfKG0dyF4aOvR2175uaak3iRU_59QvSSUpvaf3bHpwbzOvESSgMMFcHF8l_Ev7h2mKw</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Wang, Li-Hui</creator><creator>Wang, Wei-Ming</creator><creator>Lin, Sheng-Hsiang</creator><creator>Shieh, Chi-Chang</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6634-6862</orcidid></search><sort><creationdate>20190701</creationdate><title>Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin’s lymphoma: a nationwide population-based study</title><author>Wang, Li-Hui ; Wang, Wei-Ming ; Lin, Sheng-Hsiang ; Shieh, Chi-Chang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-2f59d90bda6b5f5005dc16734d868060204f7c6a6baf2ced75891c0bd91a65cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - epidemiology</topic><topic>Lymphoma</topic><topic>Lymphoma, Non-Hodgkin - complications</topic><topic>Lymphoma, Non-Hodgkin - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Non-Hodgkin's lymphoma</topic><topic>Population</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Risk Assessment - methods</topic><topic>Systemic lupus erythematosus</topic><topic>Taiwan - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Li-Hui</creatorcontrib><creatorcontrib>Wang, Wei-Ming</creatorcontrib><creatorcontrib>Lin, Sheng-Hsiang</creatorcontrib><creatorcontrib>Shieh, Chi-Chang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Li-Hui</au><au>Wang, Wei-Ming</au><au>Lin, Sheng-Hsiang</au><au>Shieh, Chi-Chang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin’s lymphoma: a nationwide population-based study</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>58</volume><issue>7</issue><spage>1245</spage><epage>1249</epage><pages>1245-1249</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><abstract>Abstract
Objectives
We conducted this nationwide population-based study in Taiwan to investigate whether there is a bidirectional relationship between SLE and non-Hodgkin’s lymphoma (NHL).
Methods
Using the National Health Insurance Research Database of Taiwan, we identified 16 417 patients with new-onset SLE without previous cancer and 25 069 patients with new-onset NHL without previous SLE as two non-overlapping cohorts from 1998–2012, and followed them until 2013. Standardized incidence ratio (SIR) for NHL in the patients with SLE and SIR for SLE in the patients with NHL were compared with the general population.
Results
Among the 16 417 patients with SLE, 512 developed cancers, including 34 with NHL. The highest SIR was that for NHL (SIR 4.2, 95% CI 2.9, 5.9) in site-specific cancer risk analysis. Among the 25 069 patients with NHL, 14 developed SLE, and the SIR was also increased (SIR 2.0, 95% CI 1.1, 3.4). The SIRs of the patients with SLE to develop NHL and the patients with NHL to develop SLE were both highest within the first year after the diagnosis of each disease.
Conclusion
This nationwide population-based study is the first study to report a bidirectional relationship between SLE and NHL. This finding may suggest being alert for the patients with SLE or NHL who have early sings of the other disease in clinical care.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>30726952</pmid><doi>10.1093/rheumatology/kez011</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-6634-6862</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1462-0324 |
| ispartof | Rheumatology (Oxford, England), 2019-07, Vol.58 (7), p.1245-1249 |
| issn | 1462-0324 1462-0332 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2229084095 |
| source | MEDLINE; Oxford University Press Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Child Cohort Studies Databases, Factual Female Follow-Up Studies Humans Incidence Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - epidemiology Lymphoma Lymphoma, Non-Hodgkin - complications Lymphoma, Non-Hodgkin - epidemiology Male Middle Aged Non-Hodgkin's lymphoma Population Population studies Population-based studies Risk Assessment - methods Systemic lupus erythematosus Taiwan - epidemiology Young Adult |
| title | Bidirectional relationship between systemic lupus erythematosus and non-Hodgkin’s lymphoma: a nationwide population-based study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-06T17%3A15%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bidirectional%20relationship%20between%20systemic%20lupus%20erythematosus%20and%20non-Hodgkin%E2%80%99s%20lymphoma:%20a%20nationwide%20population-based%20study&rft.jtitle=Rheumatology%20(Oxford,%20England)&rft.au=Wang,%20Li-Hui&rft.date=2019-07-01&rft.volume=58&rft.issue=7&rft.spage=1245&rft.epage=1249&rft.pages=1245-1249&rft.issn=1462-0324&rft.eissn=1462-0332&rft_id=info:doi/10.1093/rheumatology/kez011&rft_dat=%3Cproquest_cross%3E2229084095%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2474921599&rft_id=info:pmid/30726952&rft_oup_id=10.1093/rheumatology/kez011&rfr_iscdi=true |