The Combination of Bifidobacterium breve and Three Prebiotic Oligosaccharides Modifies Gut Immune and Endocrine Functions in Neonatal Mice
Several types of oligosaccharides are used in infant formula to improve the gut microbiota of formula-fed infants. We previously reported that a combination of 3 oligosaccharides (lactulose, raffinose, and galacto-oligosaccharides; LRG) and Bifidobacterium breve effectively increased B. breve number...
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| Veröffentlicht in: | The Journal of nutrition 2019-02, Vol.149 (2), p.344-353 |
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| creator | Izumi, Hirohisa Ehara, Tatsuya Sugahara, Hirosuke Matsubara, Takeshi Mitsuyama, Eri Nakazato, Yuki Tsuda, Muneya Shimizu, Takashi Odamaki, Toshitaka Xiao, Jin-zhong Takeda, Yasuhiro |
| description | Several types of oligosaccharides are used in infant formula to improve the gut microbiota of formula-fed infants. We previously reported that a combination of 3 oligosaccharides (lactulose, raffinose, and galacto-oligosaccharides; LRG) and Bifidobacterium breve effectively increased B. breve numbers, acetate, and the expression of several immune- and gut hormone-related mRNAs in neonatal mice gut.
We investigated whether changes in neonatal gut microbiota alter gut immune and endocrine development.
We first compared postnatal day (PD) 14 with PD21 in C57BL/6J male mouse pups to identify the physiologic immune and endocrine changes during development. In a separate study, we administered phosphate-buffered saline (control group; CON), B. breve M-16V (M-16V), or M-16V + LRG to male mouse pups from PD6 to PD13, and analyzed the gut microbiota and immune and endocrine parameters on PD14 to evaluate whether M-16V + LRG accelerates gut immune and endocrine development.
The proportion of regulatory T (Treg) cells in the CD4+ cells of large intestinal lamina propria lymphocytes (LPLs) was significantly increased (63% higher) at PD21 compared with PD14. The serum glucagon-like peptide (GLP)-1 tended to be lower (P = 0.0515) and that of GLP-2 was significantly lower (58% lower) at PD21 than at PD14. M-16V + LRG significantly increased the Treg proportion in large intestinal LPL CD4+ cells (20% and 29% higher compared with CON and M-16V, respectively) at PD14. M-16V + LRG also caused significant changes in expression of large intestinal mRNAs that are consistent with developmental progression, and increased serum concentrations of GLP-1 (207% and 311% higher compared with CON and M-16V, respectively) and GLP-2 (57% and 97% higher compared with CON and M-16V, respectively) at PD14.
Neonatal administration of M-16V + LRG alters the gut microbiota and enhances gut immune and endocrine development in suckling mice. |
| doi_str_mv | 10.1093/jn/nxy248 |
| format | Article |
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We investigated whether changes in neonatal gut microbiota alter gut immune and endocrine development.
We first compared postnatal day (PD) 14 with PD21 in C57BL/6J male mouse pups to identify the physiologic immune and endocrine changes during development. In a separate study, we administered phosphate-buffered saline (control group; CON), B. breve M-16V (M-16V), or M-16V + LRG to male mouse pups from PD6 to PD13, and analyzed the gut microbiota and immune and endocrine parameters on PD14 to evaluate whether M-16V + LRG accelerates gut immune and endocrine development.
The proportion of regulatory T (Treg) cells in the CD4+ cells of large intestinal lamina propria lymphocytes (LPLs) was significantly increased (63% higher) at PD21 compared with PD14. The serum glucagon-like peptide (GLP)-1 tended to be lower (P = 0.0515) and that of GLP-2 was significantly lower (58% lower) at PD21 than at PD14. M-16V + LRG significantly increased the Treg proportion in large intestinal LPL CD4+ cells (20% and 29% higher compared with CON and M-16V, respectively) at PD14. M-16V + LRG also caused significant changes in expression of large intestinal mRNAs that are consistent with developmental progression, and increased serum concentrations of GLP-1 (207% and 311% higher compared with CON and M-16V, respectively) and GLP-2 (57% and 97% higher compared with CON and M-16V, respectively) at PD14.
Neonatal administration of M-16V + LRG alters the gut microbiota and enhances gut immune and endocrine development in suckling mice.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/nxy248</identifier><identifier>PMID: 30721975</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acetic acid ; Animals ; Animals, Newborn ; Baby foods ; Bifidobacteria ; Bifidobacterium breve ; CD4 antigen ; Digestive system ; Galactooligosaccharides ; Gastrointestinal tract ; Glucagon ; Immune system ; Infants ; Intestine ; Intestines - immunology ; Intestines - physiology ; Lactulose ; Lamina propria ; Lymph Nodes - cytology ; Lymphocytes ; Lymphocytes - physiology ; Lymphocytes T ; Mice ; Mice, Inbred C57BL ; Microbiota ; Mucous Membrane - cytology ; Neonates ; Newborn babies ; Oligosaccharides ; Oligosaccharides - pharmacology ; Prebiotics - administration & dosage ; Probiotics - administration & dosage ; Probiotics - pharmacology ; Raffinose ; regulatory T cell ; Ribonucleic acid ; RNA ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Rodents ; short-chain fatty acid ; T-Lymphocytes, Regulatory ; Th17 cell</subject><ispartof>The Journal of nutrition, 2019-02, Vol.149 (2), p.344-353</ispartof><rights>2019 American Society for Nutrition.</rights><rights>2019 American Society for Nutrition. 2019</rights><rights>Copyright American Institute of Nutrition Feb 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-e9efba1fe420dcd76a68a3a103d15af74fadd538e700cb05373504d934b8868d3</citedby><cites>FETCH-LOGICAL-c421t-e9efba1fe420dcd76a68a3a103d15af74fadd538e700cb05373504d934b8868d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30721975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Izumi, Hirohisa</creatorcontrib><creatorcontrib>Ehara, Tatsuya</creatorcontrib><creatorcontrib>Sugahara, Hirosuke</creatorcontrib><creatorcontrib>Matsubara, Takeshi</creatorcontrib><creatorcontrib>Mitsuyama, Eri</creatorcontrib><creatorcontrib>Nakazato, Yuki</creatorcontrib><creatorcontrib>Tsuda, Muneya</creatorcontrib><creatorcontrib>Shimizu, Takashi</creatorcontrib><creatorcontrib>Odamaki, Toshitaka</creatorcontrib><creatorcontrib>Xiao, Jin-zhong</creatorcontrib><creatorcontrib>Takeda, Yasuhiro</creatorcontrib><title>The Combination of Bifidobacterium breve and Three Prebiotic Oligosaccharides Modifies Gut Immune and Endocrine Functions in Neonatal Mice</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Several types of oligosaccharides are used in infant formula to improve the gut microbiota of formula-fed infants. We previously reported that a combination of 3 oligosaccharides (lactulose, raffinose, and galacto-oligosaccharides; LRG) and Bifidobacterium breve effectively increased B. breve numbers, acetate, and the expression of several immune- and gut hormone-related mRNAs in neonatal mice gut.
We investigated whether changes in neonatal gut microbiota alter gut immune and endocrine development.
We first compared postnatal day (PD) 14 with PD21 in C57BL/6J male mouse pups to identify the physiologic immune and endocrine changes during development. In a separate study, we administered phosphate-buffered saline (control group; CON), B. breve M-16V (M-16V), or M-16V + LRG to male mouse pups from PD6 to PD13, and analyzed the gut microbiota and immune and endocrine parameters on PD14 to evaluate whether M-16V + LRG accelerates gut immune and endocrine development.
The proportion of regulatory T (Treg) cells in the CD4+ cells of large intestinal lamina propria lymphocytes (LPLs) was significantly increased (63% higher) at PD21 compared with PD14. The serum glucagon-like peptide (GLP)-1 tended to be lower (P = 0.0515) and that of GLP-2 was significantly lower (58% lower) at PD21 than at PD14. M-16V + LRG significantly increased the Treg proportion in large intestinal LPL CD4+ cells (20% and 29% higher compared with CON and M-16V, respectively) at PD14. M-16V + LRG also caused significant changes in expression of large intestinal mRNAs that are consistent with developmental progression, and increased serum concentrations of GLP-1 (207% and 311% higher compared with CON and M-16V, respectively) and GLP-2 (57% and 97% higher compared with CON and M-16V, respectively) at PD14.
Neonatal administration of M-16V + LRG alters the gut microbiota and enhances gut immune and endocrine development in suckling mice.</description><subject>Acetic acid</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Baby foods</subject><subject>Bifidobacteria</subject><subject>Bifidobacterium breve</subject><subject>CD4 antigen</subject><subject>Digestive system</subject><subject>Galactooligosaccharides</subject><subject>Gastrointestinal tract</subject><subject>Glucagon</subject><subject>Immune system</subject><subject>Infants</subject><subject>Intestine</subject><subject>Intestines - immunology</subject><subject>Intestines - physiology</subject><subject>Lactulose</subject><subject>Lamina propria</subject><subject>Lymph Nodes - cytology</subject><subject>Lymphocytes</subject><subject>Lymphocytes - physiology</subject><subject>Lymphocytes T</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiota</subject><subject>Mucous Membrane - cytology</subject><subject>Neonates</subject><subject>Newborn babies</subject><subject>Oligosaccharides</subject><subject>Oligosaccharides - pharmacology</subject><subject>Prebiotics - administration & dosage</subject><subject>Probiotics - administration & dosage</subject><subject>Probiotics - pharmacology</subject><subject>Raffinose</subject><subject>regulatory T cell</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>short-chain fatty acid</subject><subject>T-Lymphocytes, Regulatory</subject><subject>Th17 cell</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctuFDEQRS0EIpPAgh9AlmABi07Kj34tYZSESHmwGNaW265mPOq2B7s7Ir_AV8dRhywixKqqpHNvleoS8o7BMYNWnOz8if99x2XzgqxYKVlRMYCXZAXAeSFYVR2Qw5R2AMBk27wmBwJqztq6XJE_my3SdRg75_Xkgqehp19d72zotJkwunmkXcRbpNpbutlGRPo9YufC5Ay9GdzPkLQxWx2dxUSvgs3i3JzPE70Yx9kvwlNvg4kuT2ezNw-LEnWeXmPIa_VAr5zBN-RVr4eEbx_rEflxdrpZfysub84v1l8uCyM5mwpsse8061FysMbWla4aLTQDYVmp-1r22tpSNFgDmA5KUYsSpG2F7Jqmaqw4Ip8W330Mv2ZMkxpdMjgM2mOYk-Kct1BXQkJGPzxDd2GOPl-nOGuq_EXeikx9XigTQ0oRe7WPbtTxTjFQDwGpnVdLQJl9_-g4dyPaJ_JvIhn4uABh3v_XRywY5k_dOowqGYfeoHURzaRscP9Q3QOvuKvm</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Izumi, Hirohisa</creator><creator>Ehara, Tatsuya</creator><creator>Sugahara, Hirosuke</creator><creator>Matsubara, Takeshi</creator><creator>Mitsuyama, Eri</creator><creator>Nakazato, Yuki</creator><creator>Tsuda, Muneya</creator><creator>Shimizu, Takashi</creator><creator>Odamaki, Toshitaka</creator><creator>Xiao, Jin-zhong</creator><creator>Takeda, Yasuhiro</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>American Institute of Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201902</creationdate><title>The Combination of Bifidobacterium breve and Three Prebiotic Oligosaccharides Modifies Gut Immune and Endocrine Functions in Neonatal Mice</title><author>Izumi, Hirohisa ; Ehara, Tatsuya ; Sugahara, Hirosuke ; Matsubara, Takeshi ; Mitsuyama, Eri ; Nakazato, Yuki ; Tsuda, Muneya ; Shimizu, Takashi ; Odamaki, Toshitaka ; Xiao, Jin-zhong ; Takeda, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-e9efba1fe420dcd76a68a3a103d15af74fadd538e700cb05373504d934b8868d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acetic acid</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Baby foods</topic><topic>Bifidobacteria</topic><topic>Bifidobacterium breve</topic><topic>CD4 antigen</topic><topic>Digestive system</topic><topic>Galactooligosaccharides</topic><topic>Gastrointestinal tract</topic><topic>Glucagon</topic><topic>Immune system</topic><topic>Infants</topic><topic>Intestine</topic><topic>Intestines - immunology</topic><topic>Intestines - physiology</topic><topic>Lactulose</topic><topic>Lamina propria</topic><topic>Lymph Nodes - cytology</topic><topic>Lymphocytes</topic><topic>Lymphocytes - physiology</topic><topic>Lymphocytes T</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiota</topic><topic>Mucous Membrane - cytology</topic><topic>Neonates</topic><topic>Newborn babies</topic><topic>Oligosaccharides</topic><topic>Oligosaccharides - pharmacology</topic><topic>Prebiotics - administration & dosage</topic><topic>Probiotics - administration & dosage</topic><topic>Probiotics - pharmacology</topic><topic>Raffinose</topic><topic>regulatory T cell</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Rodents</topic><topic>short-chain fatty acid</topic><topic>T-Lymphocytes, Regulatory</topic><topic>Th17 cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Izumi, Hirohisa</creatorcontrib><creatorcontrib>Ehara, Tatsuya</creatorcontrib><creatorcontrib>Sugahara, Hirosuke</creatorcontrib><creatorcontrib>Matsubara, Takeshi</creatorcontrib><creatorcontrib>Mitsuyama, Eri</creatorcontrib><creatorcontrib>Nakazato, Yuki</creatorcontrib><creatorcontrib>Tsuda, Muneya</creatorcontrib><creatorcontrib>Shimizu, Takashi</creatorcontrib><creatorcontrib>Odamaki, Toshitaka</creatorcontrib><creatorcontrib>Xiao, Jin-zhong</creatorcontrib><creatorcontrib>Takeda, Yasuhiro</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Izumi, Hirohisa</au><au>Ehara, Tatsuya</au><au>Sugahara, Hirosuke</au><au>Matsubara, Takeshi</au><au>Mitsuyama, Eri</au><au>Nakazato, Yuki</au><au>Tsuda, Muneya</au><au>Shimizu, Takashi</au><au>Odamaki, Toshitaka</au><au>Xiao, Jin-zhong</au><au>Takeda, Yasuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Combination of Bifidobacterium breve and Three Prebiotic Oligosaccharides Modifies Gut Immune and Endocrine Functions in Neonatal Mice</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2019-02</date><risdate>2019</risdate><volume>149</volume><issue>2</issue><spage>344</spage><epage>353</epage><pages>344-353</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>Several types of oligosaccharides are used in infant formula to improve the gut microbiota of formula-fed infants. We previously reported that a combination of 3 oligosaccharides (lactulose, raffinose, and galacto-oligosaccharides; LRG) and Bifidobacterium breve effectively increased B. breve numbers, acetate, and the expression of several immune- and gut hormone-related mRNAs in neonatal mice gut.
We investigated whether changes in neonatal gut microbiota alter gut immune and endocrine development.
We first compared postnatal day (PD) 14 with PD21 in C57BL/6J male mouse pups to identify the physiologic immune and endocrine changes during development. In a separate study, we administered phosphate-buffered saline (control group; CON), B. breve M-16V (M-16V), or M-16V + LRG to male mouse pups from PD6 to PD13, and analyzed the gut microbiota and immune and endocrine parameters on PD14 to evaluate whether M-16V + LRG accelerates gut immune and endocrine development.
The proportion of regulatory T (Treg) cells in the CD4+ cells of large intestinal lamina propria lymphocytes (LPLs) was significantly increased (63% higher) at PD21 compared with PD14. The serum glucagon-like peptide (GLP)-1 tended to be lower (P = 0.0515) and that of GLP-2 was significantly lower (58% lower) at PD21 than at PD14. M-16V + LRG significantly increased the Treg proportion in large intestinal LPL CD4+ cells (20% and 29% higher compared with CON and M-16V, respectively) at PD14. M-16V + LRG also caused significant changes in expression of large intestinal mRNAs that are consistent with developmental progression, and increased serum concentrations of GLP-1 (207% and 311% higher compared with CON and M-16V, respectively) and GLP-2 (57% and 97% higher compared with CON and M-16V, respectively) at PD14.
Neonatal administration of M-16V + LRG alters the gut microbiota and enhances gut immune and endocrine development in suckling mice.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30721975</pmid><doi>10.1093/jn/nxy248</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetic acid Animals Animals, Newborn Baby foods Bifidobacteria Bifidobacterium breve CD4 antigen Digestive system Galactooligosaccharides Gastrointestinal tract Glucagon Immune system Infants Intestine Intestines - immunology Intestines - physiology Lactulose Lamina propria Lymph Nodes - cytology Lymphocytes Lymphocytes - physiology Lymphocytes T Mice Mice, Inbred C57BL Microbiota Mucous Membrane - cytology Neonates Newborn babies Oligosaccharides Oligosaccharides - pharmacology Prebiotics - administration & dosage Probiotics - administration & dosage Probiotics - pharmacology Raffinose regulatory T cell Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism Rodents short-chain fatty acid T-Lymphocytes, Regulatory Th17 cell |
| title | The Combination of Bifidobacterium breve and Three Prebiotic Oligosaccharides Modifies Gut Immune and Endocrine Functions in Neonatal Mice |
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