Home-Time as a Surrogate Marker for Functional Outcome After Aneurysmal Subarachnoid Hemorrhage
BACKGROUND AND PURPOSE—Commonly used tools to determine functional outcome after aneurysmal subarachnoid hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust outcome measure after ischemic stroke. Here, we set out to validate home-time as an o...
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| Veröffentlicht in: | Stroke (1970) 2018-12, Vol.49 (12), p.3081-3084 |
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| container_title | Stroke (1970) |
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| creator | Stienen, Martin Nikolaus Smoll, Nicolas Roydon Fung, Christian Goldberg, Johannes Bervini, David Maduri, Rodolfo Chiappini, Alessio Robert, Thomas May, Adrien Bijlenga, Philippe Zumofen, Daniel Roethlisberger, Michel Seule, Martin Alexander Marbacher, Serge Fandino, Javier Schatlo, Bawarjan Schaller, Karl Keller, Emanuela Bozinov, Oliver Regli, Luca |
| description | BACKGROUND AND PURPOSE—Commonly used tools to determine functional outcome after aneurysmal subarachnoid hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust outcome measure after ischemic stroke. Here, we set out to validate home-time as an outcome measure after aSAH.
METHODS—We examined prospectively collected data from a nationwide multicenter registry of aSAH patients admitted to a tertiary neurosurgical department in Switzerland (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid Hemorrhage]; 2009–2015). We calculated mean home-time (defined as days spent at home for the first 90 days after aSAH) and 95% CIs for each category of modified Rankin Scale at discharge and 1-year follow-up, using linear regression models to analyze home-time differences per modified Rankin Scale category.
RESULTS—We had home-time data from 1076 of 1866 patients (57.7%), and multiple imputation was used to fill-in missing data from the remaining 790 patients. Increasing home-time was associated with improved modified Rankin Scale scores at time of hospital discharge (P |
| doi_str_mv | 10.1161/STROKEAHA.118.022808 |
| format | Article |
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METHODS—We examined prospectively collected data from a nationwide multicenter registry of aSAH patients admitted to a tertiary neurosurgical department in Switzerland (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid Hemorrhage]; 2009–2015). We calculated mean home-time (defined as days spent at home for the first 90 days after aSAH) and 95% CIs for each category of modified Rankin Scale at discharge and 1-year follow-up, using linear regression models to analyze home-time differences per modified Rankin Scale category.
RESULTS—We had home-time data from 1076 of 1866 patients (57.7%), and multiple imputation was used to fill-in missing data from the remaining 790 patients. Increasing home-time was associated with improved modified Rankin Scale scores at time of hospital discharge (P<0.0001) and at 1-year follow-up (P<0.0001). Within each of the 8 participating hospitals, the relationship between home-time and modified Rankin Scale was maintained.
CONCLUSIONS—Home-time for the first 90 days after aSAH offers a robust and easily ascertainable outcome measure, discriminating particularly well across better recovery levels at time of hospital discharge and at 1-year follow-up. This measure complies with the modern trend of patient-centered healthcare and research, representing an outcome that is particularly relevant to the patient.
CLINICAL TRIAL REGISTRATION—URLhttps://clinicaltrials.gov. Unique identifierNCT03245866.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.118.022808</identifier><identifier>PMID: 30735342</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><ispartof>Stroke (1970), 2018-12, Vol.49 (12), p.3081-3084</ispartof><rights>2018 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4028-15c286791999867069673ba3fe289dc0d1e0e60d765fc343f4354b5b71076683</citedby><cites>FETCH-LOGICAL-c4028-15c286791999867069673ba3fe289dc0d1e0e60d765fc343f4354b5b71076683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30735342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stienen, Martin Nikolaus</creatorcontrib><creatorcontrib>Smoll, Nicolas Roydon</creatorcontrib><creatorcontrib>Fung, Christian</creatorcontrib><creatorcontrib>Goldberg, Johannes</creatorcontrib><creatorcontrib>Bervini, David</creatorcontrib><creatorcontrib>Maduri, Rodolfo</creatorcontrib><creatorcontrib>Chiappini, Alessio</creatorcontrib><creatorcontrib>Robert, Thomas</creatorcontrib><creatorcontrib>May, Adrien</creatorcontrib><creatorcontrib>Bijlenga, Philippe</creatorcontrib><creatorcontrib>Zumofen, Daniel</creatorcontrib><creatorcontrib>Roethlisberger, Michel</creatorcontrib><creatorcontrib>Seule, Martin Alexander</creatorcontrib><creatorcontrib>Marbacher, Serge</creatorcontrib><creatorcontrib>Fandino, Javier</creatorcontrib><creatorcontrib>Schatlo, Bawarjan</creatorcontrib><creatorcontrib>Schaller, Karl</creatorcontrib><creatorcontrib>Keller, Emanuela</creatorcontrib><creatorcontrib>Bozinov, Oliver</creatorcontrib><creatorcontrib>Regli, Luca</creatorcontrib><creatorcontrib>Swiss SOS Study Group</creatorcontrib><creatorcontrib>on behalf of the Swiss SOS Study Group</creatorcontrib><title>Home-Time as a Surrogate Marker for Functional Outcome After Aneurysmal Subarachnoid Hemorrhage</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>BACKGROUND AND PURPOSE—Commonly used tools to determine functional outcome after aneurysmal subarachnoid hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust outcome measure after ischemic stroke. Here, we set out to validate home-time as an outcome measure after aSAH.
METHODS—We examined prospectively collected data from a nationwide multicenter registry of aSAH patients admitted to a tertiary neurosurgical department in Switzerland (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid Hemorrhage]; 2009–2015). We calculated mean home-time (defined as days spent at home for the first 90 days after aSAH) and 95% CIs for each category of modified Rankin Scale at discharge and 1-year follow-up, using linear regression models to analyze home-time differences per modified Rankin Scale category.
RESULTS—We had home-time data from 1076 of 1866 patients (57.7%), and multiple imputation was used to fill-in missing data from the remaining 790 patients. Increasing home-time was associated with improved modified Rankin Scale scores at time of hospital discharge (P<0.0001) and at 1-year follow-up (P<0.0001). Within each of the 8 participating hospitals, the relationship between home-time and modified Rankin Scale was maintained.
CONCLUSIONS—Home-time for the first 90 days after aSAH offers a robust and easily ascertainable outcome measure, discriminating particularly well across better recovery levels at time of hospital discharge and at 1-year follow-up. This measure complies with the modern trend of patient-centered healthcare and research, representing an outcome that is particularly relevant to the patient.
CLINICAL TRIAL REGISTRATION—URLhttps://clinicaltrials.gov. Unique identifierNCT03245866.</description><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMtu1DAUhi0EotPCGyCUJZuU42vsZVS1DGrRSMzsLcc56YQmcbFjVX17jKZ0yero13850kfIJwqXlCr6dX_4ubu9brdtkfoSGNOg35ANlUzUQjH9lmwAuKmZMOaMnKf0CwAY1_I9OePQcMkF2xC7DTPWh3HGyqXKVfscY7h3K1Y_XHzAWA0hVjd58esYFjdVu7z60qjaYS1mu2COz2kuxj53Ljp_XMLYV1ucQ4xHd48fyLvBTQk_vtwLcri5Plxt67vdt-9X7V3tBTBdU-mZVo2hxphyQRnV8M7xAZk2vYeeIqCCvlFy8FzwQXApOtk1FBqlNL8gX06zjzH8zphWO4_J4zS5BUNOljFmoJFSQomKU9THkFLEwT7GcXbx2VKwf8naV7JFansiW2qfXz7kbsb-tfQPZQnoU-ApTIVNepjyE0Z7RDetx_9v_wEf5IW7</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Stienen, Martin Nikolaus</creator><creator>Smoll, Nicolas Roydon</creator><creator>Fung, Christian</creator><creator>Goldberg, Johannes</creator><creator>Bervini, David</creator><creator>Maduri, Rodolfo</creator><creator>Chiappini, Alessio</creator><creator>Robert, Thomas</creator><creator>May, Adrien</creator><creator>Bijlenga, Philippe</creator><creator>Zumofen, Daniel</creator><creator>Roethlisberger, Michel</creator><creator>Seule, Martin Alexander</creator><creator>Marbacher, Serge</creator><creator>Fandino, Javier</creator><creator>Schatlo, Bawarjan</creator><creator>Schaller, Karl</creator><creator>Keller, Emanuela</creator><creator>Bozinov, Oliver</creator><creator>Regli, Luca</creator><general>American Heart Association, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201812</creationdate><title>Home-Time as a Surrogate Marker for Functional Outcome After Aneurysmal Subarachnoid Hemorrhage</title><author>Stienen, Martin Nikolaus ; Smoll, Nicolas Roydon ; Fung, Christian ; Goldberg, Johannes ; Bervini, David ; Maduri, Rodolfo ; Chiappini, Alessio ; Robert, Thomas ; May, Adrien ; Bijlenga, Philippe ; Zumofen, Daniel ; Roethlisberger, Michel ; Seule, Martin Alexander ; Marbacher, Serge ; Fandino, Javier ; Schatlo, Bawarjan ; Schaller, Karl ; Keller, Emanuela ; Bozinov, Oliver ; Regli, Luca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4028-15c286791999867069673ba3fe289dc0d1e0e60d765fc343f4354b5b71076683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stienen, Martin Nikolaus</creatorcontrib><creatorcontrib>Smoll, Nicolas Roydon</creatorcontrib><creatorcontrib>Fung, Christian</creatorcontrib><creatorcontrib>Goldberg, Johannes</creatorcontrib><creatorcontrib>Bervini, David</creatorcontrib><creatorcontrib>Maduri, Rodolfo</creatorcontrib><creatorcontrib>Chiappini, Alessio</creatorcontrib><creatorcontrib>Robert, Thomas</creatorcontrib><creatorcontrib>May, Adrien</creatorcontrib><creatorcontrib>Bijlenga, Philippe</creatorcontrib><creatorcontrib>Zumofen, Daniel</creatorcontrib><creatorcontrib>Roethlisberger, Michel</creatorcontrib><creatorcontrib>Seule, Martin Alexander</creatorcontrib><creatorcontrib>Marbacher, Serge</creatorcontrib><creatorcontrib>Fandino, Javier</creatorcontrib><creatorcontrib>Schatlo, Bawarjan</creatorcontrib><creatorcontrib>Schaller, Karl</creatorcontrib><creatorcontrib>Keller, Emanuela</creatorcontrib><creatorcontrib>Bozinov, Oliver</creatorcontrib><creatorcontrib>Regli, Luca</creatorcontrib><creatorcontrib>Swiss SOS Study Group</creatorcontrib><creatorcontrib>on behalf of the Swiss SOS Study Group</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stienen, Martin Nikolaus</au><au>Smoll, Nicolas Roydon</au><au>Fung, Christian</au><au>Goldberg, Johannes</au><au>Bervini, David</au><au>Maduri, Rodolfo</au><au>Chiappini, Alessio</au><au>Robert, Thomas</au><au>May, Adrien</au><au>Bijlenga, Philippe</au><au>Zumofen, Daniel</au><au>Roethlisberger, Michel</au><au>Seule, Martin Alexander</au><au>Marbacher, Serge</au><au>Fandino, Javier</au><au>Schatlo, Bawarjan</au><au>Schaller, Karl</au><au>Keller, Emanuela</au><au>Bozinov, Oliver</au><au>Regli, Luca</au><aucorp>Swiss SOS Study Group</aucorp><aucorp>on behalf of the Swiss SOS Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Home-Time as a Surrogate Marker for Functional Outcome After Aneurysmal Subarachnoid Hemorrhage</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2018-12</date><risdate>2018</risdate><volume>49</volume><issue>12</issue><spage>3081</spage><epage>3084</epage><pages>3081-3084</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><abstract>BACKGROUND AND PURPOSE—Commonly used tools to determine functional outcome after aneurysmal subarachnoid hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust outcome measure after ischemic stroke. Here, we set out to validate home-time as an outcome measure after aSAH.
METHODS—We examined prospectively collected data from a nationwide multicenter registry of aSAH patients admitted to a tertiary neurosurgical department in Switzerland (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid Hemorrhage]; 2009–2015). We calculated mean home-time (defined as days spent at home for the first 90 days after aSAH) and 95% CIs for each category of modified Rankin Scale at discharge and 1-year follow-up, using linear regression models to analyze home-time differences per modified Rankin Scale category.
RESULTS—We had home-time data from 1076 of 1866 patients (57.7%), and multiple imputation was used to fill-in missing data from the remaining 790 patients. Increasing home-time was associated with improved modified Rankin Scale scores at time of hospital discharge (P<0.0001) and at 1-year follow-up (P<0.0001). Within each of the 8 participating hospitals, the relationship between home-time and modified Rankin Scale was maintained.
CONCLUSIONS—Home-time for the first 90 days after aSAH offers a robust and easily ascertainable outcome measure, discriminating particularly well across better recovery levels at time of hospital discharge and at 1-year follow-up. This measure complies with the modern trend of patient-centered healthcare and research, representing an outcome that is particularly relevant to the patient.
CLINICAL TRIAL REGISTRATION—URLhttps://clinicaltrials.gov. Unique identifierNCT03245866.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>30735342</pmid><doi>10.1161/STROKEAHA.118.022808</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| title | Home-Time as a Surrogate Marker for Functional Outcome After Aneurysmal Subarachnoid Hemorrhage |
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