Fisetin activates Hippo pathway and JNK/ERK/AP‐1 signaling to inhibit proliferation and induce apoptosis of human osteosarcoma cells via ZAK overexpression

Osteosarcoma (OS) is a tumor entity that can cause a large number of cancer‐related deaths. Although chemotherapy can decrease proliferation and increase apoptosis of human OS cells, the clinical prognosis remains poor. Fisetin is a flavonol found in fruits and vegetables and is reported to inhibit...

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Veröffentlicht in:	Environmental toxicology 2019-08, Vol.34 (8), p.902-911
Hauptverfasser:	Fu, Chien‐Yao, Chen, Mei‐Chih, Tseng, Yan‐Shen, Chen, Ming‐Cheng, Zhou, Zhengtao, Yang, Jaw‐Ji, Lin, Yueh‐Min, Viswanadha, Vijaya P., Wang, Guiqing, Huang, Chih‐Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Biocompatibility Bone cancer Bone Neoplasms - enzymology Bone Neoplasms - metabolism Bone Neoplasms - pathology Cancer Cell Line, Tumor Cell Proliferation Chemotherapy Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism fisetin Flavonoids - pharmacology hippo pathway Humans JNK Mitogen-Activated Protein Kinases - metabolism Kinases Leucine Leucine zipper proteins MAP Kinase Kinase Kinases MAP Kinase Signaling System Neoplasms Osteosarcoma Osteosarcoma - enzymology Osteosarcoma - metabolism Osteosarcoma - pathology Osteosarcoma cells Proliferation Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Sarcoma Signal Transduction Transcription Factor AP-1 - metabolism Tumor Suppressor Proteins - metabolism ZAK
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