Effects of ajmaline on contraction patterns of isolated rat gastric antrum and portal vein smooth muscle strips and on neurogenic relaxations of gastric fundus

Class-I-antiarrhythmics like ajmaline are known to alter smooth muscle function, which may cause alterations in gastrointestinal motility. The effects of ajmaline on isolated gastric and portal vein smooth muscle and the underlying mechanisms are unknown. We studied the effects of ajmaline on the co...

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Veröffentlicht in:	Pflügers Archiv 2019-07, Vol.471 (7), p.995-1005
Hauptverfasser:	Patejdl, Robert, Gromann, Alina, Bänsch, Dietmar, Noack, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Ajmaline - pharmacology Animals Atropine Atropine - pharmacology Biomedical and Life Sciences Biomedicine Cell Biology Contraction Electric fields Electric Stimulation - methods Enteric nervous system Female Gastric Fundus - drug effects Gastric motility Gastrointestinal Motility - drug effects Human Physiology Male Molecular Medicine Muscle contraction Muscle Contraction - drug effects Muscle, Smooth - drug effects Neurosciences Neurotransmission Organ Physiology Portal vein Portal Vein - drug effects Pyloric Antrum - drug effects Rats Rats, Wistar Receptors Smooth muscle Stomach Synaptic Transmission - drug effects Tetrodotoxin Tetrodotoxin - pharmacology
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