Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife
Alcohol consumption is a modifiable and plausible risk factor for age-related cognitive decline but more longitudinal studies investigating the association are needed. Our aims were to estimate associations of adult-life alcohol consumption and consumption patterns with age-related cognitive decline...
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| Veröffentlicht in: | Alcohol and alcoholism (Oxford) 2019-07, Vol.54 (4), p.446-454 |
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| container_title | Alcohol and alcoholism (Oxford) |
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| creator | Grønkjær, Marie Flensborg-Madsen, Trine Osler, Merete Sørensen, Holger J Becker, Ulrik Mortensen, Erik L |
| description | Alcohol consumption is a modifiable and plausible risk factor for age-related cognitive decline but more longitudinal studies investigating the association are needed. Our aims were to estimate associations of adult-life alcohol consumption and consumption patterns with age-related cognitive decline.
We investigated the associations of self-reported adult-life weekly alcohol consumption and weekly extreme binge drinking (≥10 units on the same occasion) with changes in test scores on an identical validated test of intelligence completed in early adulthood and late midlife in 2498 Danish men from the Lifestyle and Cognition Follow-up study 2015. Analyses were adjusted for year of birth, retest interval, baseline IQ, education and smoking.
Men with adult-life alcohol consumption of more than 28 units/week had a larger decline in IQ scores from early adulthood to late midlife than men consuming 1-14 units/week (B29-35units/week = -3.6; P < 0.001). Likewise, a 1-year increase in weekly extreme binge drinking was associated with a 0.12-point decline in IQ scores (P < 0.001). Weekly extreme binge drinking explained more variance in IQ changes than average weekly consumption. In analyses including mutual adjustment of weekly extreme binge drinking and average weekly alcohol consumption, the estimated IQ decline associated with extreme binge drinking was largely unaffected, whereas the association with weekly alcohol consumption became non-significant.
Adult-life heavy alcohol consumption and extreme binge drinking appear to be associated with larger cognitive decline in men. Moreover, extreme binge drinking may be more important than weekly alcohol consumption in relation to cognitive decline. |
| doi_str_mv | 10.1093/alcalc/agz038 |
| format | Article |
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We investigated the associations of self-reported adult-life weekly alcohol consumption and weekly extreme binge drinking (≥10 units on the same occasion) with changes in test scores on an identical validated test of intelligence completed in early adulthood and late midlife in 2498 Danish men from the Lifestyle and Cognition Follow-up study 2015. Analyses were adjusted for year of birth, retest interval, baseline IQ, education and smoking.
Men with adult-life alcohol consumption of more than 28 units/week had a larger decline in IQ scores from early adulthood to late midlife than men consuming 1-14 units/week (B29-35units/week = -3.6; P < 0.001). Likewise, a 1-year increase in weekly extreme binge drinking was associated with a 0.12-point decline in IQ scores (P < 0.001). Weekly extreme binge drinking explained more variance in IQ changes than average weekly consumption. In analyses including mutual adjustment of weekly extreme binge drinking and average weekly alcohol consumption, the estimated IQ decline associated with extreme binge drinking was largely unaffected, whereas the association with weekly alcohol consumption became non-significant.
Adult-life heavy alcohol consumption and extreme binge drinking appear to be associated with larger cognitive decline in men. Moreover, extreme binge drinking may be more important than weekly alcohol consumption in relation to cognitive decline.</description><identifier>ISSN: 0735-0414</identifier><identifier>EISSN: 1464-3502</identifier><identifier>DOI: 10.1093/alcalc/agz038</identifier><identifier>PMID: 31044220</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aging - psychology ; Alcohol Drinking - epidemiology ; Alcohol Drinking - psychology ; Alcohol Drinking - trends ; Binge Drinking - epidemiology ; Binge Drinking - psychology ; Binge Drinking - trends ; Cognitive Dysfunction - epidemiology ; Cognitive Dysfunction - psychology ; Denmark - epidemiology ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neuropsychological Tests</subject><ispartof>Alcohol and alcoholism (Oxford), 2019-07, Vol.54 (4), p.446-454</ispartof><rights>The Author(s) 2019. Medical Council on Alcohol and Oxford University Press. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c293t-2beb896fab7148b145ab7e4b00841b113fd809bc8725d2977c6b0ee887bf07a03</citedby><cites>FETCH-LOGICAL-c293t-2beb896fab7148b145ab7e4b00841b113fd809bc8725d2977c6b0ee887bf07a03</cites><orcidid>0000-0002-7049-0952 ; 0000-0002-6921-220X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31044220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grønkjær, Marie</creatorcontrib><creatorcontrib>Flensborg-Madsen, Trine</creatorcontrib><creatorcontrib>Osler, Merete</creatorcontrib><creatorcontrib>Sørensen, Holger J</creatorcontrib><creatorcontrib>Becker, Ulrik</creatorcontrib><creatorcontrib>Mortensen, Erik L</creatorcontrib><title>Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife</title><title>Alcohol and alcoholism (Oxford)</title><addtitle>Alcohol Alcohol</addtitle><description>Alcohol consumption is a modifiable and plausible risk factor for age-related cognitive decline but more longitudinal studies investigating the association are needed. Our aims were to estimate associations of adult-life alcohol consumption and consumption patterns with age-related cognitive decline.
We investigated the associations of self-reported adult-life weekly alcohol consumption and weekly extreme binge drinking (≥10 units on the same occasion) with changes in test scores on an identical validated test of intelligence completed in early adulthood and late midlife in 2498 Danish men from the Lifestyle and Cognition Follow-up study 2015. Analyses were adjusted for year of birth, retest interval, baseline IQ, education and smoking.
Men with adult-life alcohol consumption of more than 28 units/week had a larger decline in IQ scores from early adulthood to late midlife than men consuming 1-14 units/week (B29-35units/week = -3.6; P < 0.001). Likewise, a 1-year increase in weekly extreme binge drinking was associated with a 0.12-point decline in IQ scores (P < 0.001). Weekly extreme binge drinking explained more variance in IQ changes than average weekly consumption. In analyses including mutual adjustment of weekly extreme binge drinking and average weekly alcohol consumption, the estimated IQ decline associated with extreme binge drinking was largely unaffected, whereas the association with weekly alcohol consumption became non-significant.
Adult-life heavy alcohol consumption and extreme binge drinking appear to be associated with larger cognitive decline in men. Moreover, extreme binge drinking may be more important than weekly alcohol consumption in relation to cognitive decline.</description><subject>Adult</subject><subject>Aging - psychology</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Alcohol Drinking - psychology</subject><subject>Alcohol Drinking - trends</subject><subject>Binge Drinking - epidemiology</subject><subject>Binge Drinking - psychology</subject><subject>Binge Drinking - trends</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Denmark - epidemiology</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><issn>0735-0414</issn><issn>1464-3502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1Lw0AQQBdRbK0evcoevcTOfqTZHEOtH1ARRM9hN5m0K5tszSZC_fVGU4WBGZjHOzxCLhncMEjFXLtimLnefIFQR2TK5EJGIgZ-TKaQiDgCyeSEnIXwDsCk4OyUTAQDKTmHKcGs7F0XrW2FNHOF33pHl74Jfb3rrG-obkqabTB6Qac7LIffprGd_UR6i4WzDdKq9TVd6dbt6a9r631JO0_XA0-fbOkG9Tk5qbQLeHHYM_J2t3pdPkTr5_vHZbaOCp6KLuIGjUoXlTYJk8owGQ8XSgOgJDOMiapUkJpCJTwueZokxcIAolKJqSDRIGbkevTuWv_RY-jy2oYCndMN-j7knDOVprEaVDMSjWjR-hBarPJda2vd7nMG-U_ZfCybj2UH_uqg7k2N5T_9l1J8A2Lhdek</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Grønkjær, Marie</creator><creator>Flensborg-Madsen, Trine</creator><creator>Osler, Merete</creator><creator>Sørensen, Holger J</creator><creator>Becker, Ulrik</creator><creator>Mortensen, Erik L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7049-0952</orcidid><orcidid>https://orcid.org/0000-0002-6921-220X</orcidid></search><sort><creationdate>20190701</creationdate><title>Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife</title><author>Grønkjær, Marie ; Flensborg-Madsen, Trine ; Osler, Merete ; Sørensen, Holger J ; Becker, Ulrik ; Mortensen, Erik L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-2beb896fab7148b145ab7e4b00841b113fd809bc8725d2977c6b0ee887bf07a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aging - psychology</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Alcohol Drinking - psychology</topic><topic>Alcohol Drinking - trends</topic><topic>Binge Drinking - epidemiology</topic><topic>Binge Drinking - psychology</topic><topic>Binge Drinking - trends</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Denmark - epidemiology</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grønkjær, Marie</creatorcontrib><creatorcontrib>Flensborg-Madsen, Trine</creatorcontrib><creatorcontrib>Osler, Merete</creatorcontrib><creatorcontrib>Sørensen, Holger J</creatorcontrib><creatorcontrib>Becker, Ulrik</creatorcontrib><creatorcontrib>Mortensen, Erik L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alcohol and alcoholism (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grønkjær, Marie</au><au>Flensborg-Madsen, Trine</au><au>Osler, Merete</au><au>Sørensen, Holger J</au><au>Becker, Ulrik</au><au>Mortensen, Erik L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife</atitle><jtitle>Alcohol and alcoholism (Oxford)</jtitle><addtitle>Alcohol Alcohol</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>54</volume><issue>4</issue><spage>446</spage><epage>454</epage><pages>446-454</pages><issn>0735-0414</issn><eissn>1464-3502</eissn><abstract>Alcohol consumption is a modifiable and plausible risk factor for age-related cognitive decline but more longitudinal studies investigating the association are needed. Our aims were to estimate associations of adult-life alcohol consumption and consumption patterns with age-related cognitive decline.
We investigated the associations of self-reported adult-life weekly alcohol consumption and weekly extreme binge drinking (≥10 units on the same occasion) with changes in test scores on an identical validated test of intelligence completed in early adulthood and late midlife in 2498 Danish men from the Lifestyle and Cognition Follow-up study 2015. Analyses were adjusted for year of birth, retest interval, baseline IQ, education and smoking.
Men with adult-life alcohol consumption of more than 28 units/week had a larger decline in IQ scores from early adulthood to late midlife than men consuming 1-14 units/week (B29-35units/week = -3.6; P < 0.001). Likewise, a 1-year increase in weekly extreme binge drinking was associated with a 0.12-point decline in IQ scores (P < 0.001). Weekly extreme binge drinking explained more variance in IQ changes than average weekly consumption. In analyses including mutual adjustment of weekly extreme binge drinking and average weekly alcohol consumption, the estimated IQ decline associated with extreme binge drinking was largely unaffected, whereas the association with weekly alcohol consumption became non-significant.
Adult-life heavy alcohol consumption and extreme binge drinking appear to be associated with larger cognitive decline in men. Moreover, extreme binge drinking may be more important than weekly alcohol consumption in relation to cognitive decline.</abstract><cop>England</cop><pmid>31044220</pmid><doi>10.1093/alcalc/agz038</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7049-0952</orcidid><orcidid>https://orcid.org/0000-0002-6921-220X</orcidid></addata></record> |
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| ispartof | Alcohol and alcoholism (Oxford), 2019-07, Vol.54 (4), p.446-454 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aging - psychology Alcohol Drinking - epidemiology Alcohol Drinking - psychology Alcohol Drinking - trends Binge Drinking - epidemiology Binge Drinking - psychology Binge Drinking - trends Cognitive Dysfunction - epidemiology Cognitive Dysfunction - psychology Denmark - epidemiology Follow-Up Studies Humans Male Middle Aged Neuropsychological Tests |
| title | Adult-Life Alcohol Consumption and Age-Related Cognitive Decline from Early Adulthood to Late Midlife |
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