Uncovered Dynamic Coupling Resolves the Ambiguous Mechanism of Phenylalanine Hydroxylase Oxygen Binding

Phenylalanine hydroxylase (PAH) is an iron enzyme catalyzing the oxidation of l-Phe to l-Tyr during phenylalanine catabolism. Dysfunction of PAH leads to the debilitating condition phenylketonuria (PKU), which prompted research into the structure and function of PAH over the last 50 years. Despite i...

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Veröffentlicht in:	The journal of physical chemistry. B 2019-05, Vol.123 (21), p.4534-4539
Hauptverfasser:	Reilley, David J, Popov, Konstantin I, Dokholyan, Nikolay V, Alexandrova, Anastassia N
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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