Siraitia grosvenorii residual extract attenuates ovalbumin-induced lung inflammation by down-regulating IL-4, IL-5, IL-13, IL-17, and MUC5AC expression in mice

Siraitia grosvenorii fruits are used in traditional medicine to treat cough, sore throat, bronchitis, and asthma. This study aimed to investigate the anti-inflammatory and anti-asthmatic effects of S. grosvenorii residual extract (SGRE) on ovalbumin (OVA)-induced asthma in mice. Asthma was induced i...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2019-08, Vol.61, p.152835-152835, Article 152835
Hauptverfasser:	Sung, Yoon-Young, Kim, Seung-Hyung, Yuk, Heung Joo, Yang, Won-Kyung, Lee, Yun Mi, Son, Eunjung, Kim, Dong-Seon
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway hyper-responsiveness Allergic lung inflammation Animals Anti-Asthmatic Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Asthma Asthma - drug therapy Asthma - metabolism Asthma - pathology Bronchoalveolar lavage Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Cucurbitaceae - chemistry Disease Models, Animal Down-Regulation - drug effects Eosinophils Eosinophils - immunology Eosinophils - pathology Interleukins - genetics Interleukins - metabolism Male Mice, Inbred BALB C Mucin 5AC - genetics Mucin 5AC - metabolism Ovalbumin - immunology Ovalbumin - toxicity Plant Extracts - pharmacology Pneumonia - chemically induced Pneumonia - drug therapy Pneumonia - pathology Residual Respiratory Hypersensitivity - chemically induced Respiratory Hypersensitivity - drug therapy Th17 Cells - immunology Th17 Cells - metabolism Th17 Cells - pathology
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