The chemokine CXCL1 and its receptor CXCR2 contribute to chronic stress‐induced depression in mice

ABSTRACT Depression is increasingly recognized as an inflammatory disease, with inflammatory crosstalk in the brain contributing its pathogenesis. Life stresses may up‐regulate inflammatory processes and promote depression. Although cytokines are central to stress‐related immune responses, their con...

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Veröffentlicht in:	The FASEB journal 2019-08, Vol.33 (8), p.8853-8864
Hauptverfasser:	Chai, Hui‐Hui, Fu, Xiao‐Chun, Ma, Liang, Sun, Hai‐Tao, Chen, Gui‐Zeng, Song, Min‐Ying, Chen, Wei‐Xuan, Chen, Yong‐Sheng, Tan, Min‐Xuan, Guo, Yan‐Wu, Li, Shao‐Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents, Second-Generation - pharmacology Apoptosis Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Chemokine CXCL1 - genetics Chemokine CXCL1 - metabolism CREB Depression - etiology Depression - genetics Depression - metabolism Fluoxetine - pharmacology Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism GSK3β BDNF Hippocampus - drug effects Hippocampus - metabolism inflammation Male Mice Mice, Inbred C57BL Neuronal Plasticity Phenylurea Compounds - pharmacology Receptors, Interleukin-8B - genetics Receptors, Interleukin-8B - metabolism Stress, Psychological - complications Thiazoles - pharmacology Triazoles - pharmacology UCMS Urea - analogs & derivatives Urea - pharmacology
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