Bis(propyl)-cognitin potentiates rehabilitation of treadmill exercise after a transient focal cerebral ischemia, possibly via inhibiting NMDA receptor and regulating VEGF expression

Combination therapies may have greater efficacy compared with monotherapy in treating stroke. We investigated the molecular mechanisms by which the combination of bis(propyl)-cognitin, an uncompetitive antagonist of NMDA receptor, and treadmill exercise promote rehabilitation after ischemic stroke....

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Veröffentlicht in:	Neurochemistry international 2019-09, Vol.128, p.143-153
Hauptverfasser:	Ke, Zheng, Hu, Shengquan, Cui, Wei, Sun, Jing, Zhang, Shaojie, Mak, Shinghung, Wang, Jiajun, Tang, Jing, Pang, Yuanping, Han, Yifan, Tong, Kaiyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bis(propyl)-cognitin Brain Ischemia - drug therapy Brain Ischemia - metabolism Brain Ischemia - rehabilitation Exercise Exercise Test - drug effects Exercise Test - methods Gene Expression Ischemia Male Motor recovery Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Stroke Tacrine - analogs & derivatives Tacrine - pharmacology Tacrine - therapeutic use Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics VEGF
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