Effect of low-level BCR-ABL1 kinase domain mutations identified by next-generation sequencing in patients with chronic myeloid leukaemia: a population-based study

Kinase domain mutations in BCR-ABL1 are associated with resistance to tyrosine kinase inhibitors in patients with chronic myeloid leukaemia. Next-generation sequencing (NGS) allows detection of low-level kinase domain mutations, but its relevance in clinical practice remains debated. We aimed to exa...

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Veröffentlicht in:	The Lancet. Haematology 2019-05, Vol.6 (5), p.e276-e284
Hauptverfasser:	Kizilors, Aytug, Crisà, Elena, Lea, Nicholas, Passera, Roberto, Mian, Syed, Anwar, Jamal, Best, Steve, Nicolini, Franck E, Ireland, Robin, Aldouri, Maadh, Pocock, Christopher, Corbett, Tim, Gale, Richard, Bart-Smith, Emily, Weston-Smith, Simon, Wykes, Clare, Kulasekararaj, Austin, Jackson, Sophie, Harrington, Patrick, McLornan, Donal, Raj, Kavita, Pagliuca, Antonio, Mufti, Ghulam J, de Lavallade, Hugues
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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