Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus

Carbon monoxide (CO) presents anti-inflammatory and antioxidant activities as a new gaseous neuromessenger produced by heme oxygenase-1 (HO-1) in the body. High salt-induced hypertension is relevant to the levels of pro-inflammatory cytokines (PICs) and oxidative stress in the hypothalamic paraventr...

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Veröffentlicht in:	Cardiovascular toxicology 2019-10, Vol.19 (5), p.451-464
Hauptverfasser:	Zhang, Dong-Dong, Liang, Yan-Feng, Qi, Jie, Kang, Kai B., Yu, Xiao-Jing, Gao, Hong-Li, Liu, Kai-Li, Chen, Yan-Mei, Shi, Xiao-Lian, Xin, Guo-Rui, Fu, Li-Yan, Kang, Yu-Ming, Cui, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Animals Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Antihypertensive Agents - metabolism Antihypertensive Agents - pharmacology Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Arterial Pressure - drug effects Attenuation Biomedical and Life Sciences Biomedicine Brain Carbon monoxide Carbon Monoxide - metabolism Carbon Monoxide - pharmacology Cardiology Copper CYBB protein Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Cytokines - metabolism Diet Disease Models, Animal Heme Heme oxygenase (decyclizing) Heme Oxygenase (Decyclizing) - metabolism Hypertension Hypertension - metabolism Hypertension - physiopathology Hypertension - prevention & control Hypothalamus IL-1β Inflammation Inflammation Mediators - metabolism Interleukin 6 Male Microinjection Norepinephrine NOX4 protein Organometallic Compounds - metabolism Organometallic Compounds - pharmacology Oxidative stress Oxidative Stress - drug effects Oxygenase Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - metabolism Paraventricular Hypothalamic Nucleus - physiopathology Paraventricular nucleus Pharmacology/Toxicology Rats, Inbred Dahl Reactive oxygen species Salts Sodium chloride Sodium Chloride, Dietary Zinc
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