Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus
Carbon monoxide (CO) presents anti-inflammatory and antioxidant activities as a new gaseous neuromessenger produced by heme oxygenase-1 (HO-1) in the body. High salt-induced hypertension is relevant to the levels of pro-inflammatory cytokines (PICs) and oxidative stress in the hypothalamic paraventr...
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| Veröffentlicht in: | Cardiovascular toxicology 2019-10, Vol.19 (5), p.451-464 |
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| creator | Zhang, Dong-Dong Liang, Yan-Feng Qi, Jie Kang, Kai B. Yu, Xiao-Jing Gao, Hong-Li Liu, Kai-Li Chen, Yan-Mei Shi, Xiao-Lian Xin, Guo-Rui Fu, Li-Yan Kang, Yu-Ming Cui, Wei |
| description | Carbon monoxide (CO) presents anti-inflammatory and antioxidant activities as a new gaseous neuromessenger produced by heme oxygenase-1 (HO-1) in the body. High salt-induced hypertension is relevant to the levels of pro-inflammatory cytokines (PICs) and oxidative stress in the hypothalamic paraventricular nucleus (PVN). We explored whether CO in PVN can attenuate high salt-induced hypertension by regulating PICs or oxidative stress. Male Dahl Salt-Sensitive rats were fed high-salt (8% NaCl) or normal-salt (0.3% NaCl) diet for 4 weeks. CORM-2, ZnPP IX, or vehicle was microinjected into bilateral PVN for 6 weeks. High-salt diet increased the levels of MAP, plasma norepinephrine (NE), reactive oxygen species (ROS), and the expressions of COX2, IL-1β, IL-6, NOX2, and NOX4 significantly in PVN (
p |
| doi_str_mv | 10.1007/s12012-019-09517-w |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2217473186</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A718099865</galeid><sourcerecordid>A718099865</sourcerecordid><originalsourceid>FETCH-LOGICAL-c552t-73d0a1a0517db4a9ad483b9ef5f4c3b815cd8f04110663cb9f52a4b485b5c3753</originalsourceid><addsrcrecordid>eNp9Ustu1DAUjRCIPuAHWCBLbNik-BHHyXI0AqZSoRUFsbQc-2bGJbGnttN2voTfxWEKFQghL2zrPHzv9SmKFwSfEIzFm0goJrTEpC1xy4kobx8Vh4TzfKW8fTyfGS5Fi_lBcRTjFcaU0po_LQ4YwUzUmB4W35cqdN6hD975O2sALVICN6kEEa3seoMu1ZDKU2cmDQatdlsIGY82S75u7ADoE2TIujW6CL60rh_UOKrkww4td8l_sy4bKWfQeXZXyd4AukwBYkTWobQBdKGCugGXgtXToAL6OOkBpviseNKrIcLz-_24-PLu7eflqjw7f3-6XJyVmnOaSsEMVkTh3L3pKtUqUzWsa6HnfaVZ1xCuTdPjihBc10x3bc-pqrqq4R3XTHB2XLze-26Dv54gJjnaqGEYlAM_RUkpEZVgpKkz9dVf1Cs_BZerm1k1b6gg1QNrrQaQeSA-BaVnU7kQpMFt29Tzsyf_YOVlYLTaO-jzbP8U0L1ABx9jgF5ugx1V2EmC5ZwGuU-DzGmQP9Mgb7Po5X3FUzeC-S359f2ZwPaEmCG3hvDQ0n9sfwBYA8D_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2216582714</pqid></control><display><type>article</type><title>Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Zhang, Dong-Dong ; Liang, Yan-Feng ; Qi, Jie ; Kang, Kai B. ; Yu, Xiao-Jing ; Gao, Hong-Li ; Liu, Kai-Li ; Chen, Yan-Mei ; Shi, Xiao-Lian ; Xin, Guo-Rui ; Fu, Li-Yan ; Kang, Yu-Ming ; Cui, Wei</creator><creatorcontrib>Zhang, Dong-Dong ; Liang, Yan-Feng ; Qi, Jie ; Kang, Kai B. ; Yu, Xiao-Jing ; Gao, Hong-Li ; Liu, Kai-Li ; Chen, Yan-Mei ; Shi, Xiao-Lian ; Xin, Guo-Rui ; Fu, Li-Yan ; Kang, Yu-Ming ; Cui, Wei</creatorcontrib><description>Carbon monoxide (CO) presents anti-inflammatory and antioxidant activities as a new gaseous neuromessenger produced by heme oxygenase-1 (HO-1) in the body. High salt-induced hypertension is relevant to the levels of pro-inflammatory cytokines (PICs) and oxidative stress in the hypothalamic paraventricular nucleus (PVN). We explored whether CO in PVN can attenuate high salt-induced hypertension by regulating PICs or oxidative stress. Male Dahl Salt-Sensitive rats were fed high-salt (8% NaCl) or normal-salt (0.3% NaCl) diet for 4 weeks. CORM-2, ZnPP IX, or vehicle was microinjected into bilateral PVN for 6 weeks. High-salt diet increased the levels of MAP, plasma norepinephrine (NE), reactive oxygen species (ROS), and the expressions of COX2, IL-1β, IL-6, NOX2, and NOX4 significantly in PVN (
p
< 0.05), but decreased the expressions of HO-1 and Cu/Zn-SOD in PVN (
p
< 0.05). Salt increased sympathetic activity as measured by circulating norepinephrine, and increased the ratio of basal RSNA to max RSNA, in part by decreasing max RSNA. PVN microinjection of CORM-2 decreased the levels of MAP, NE, RSNA, ROS and the expressions of COX2, IL-1β, IL-6, NOX2, NOX4 significantly in PVN of hypertensive rat (
p
< 0.05), but increased the expressions of HO-1 and Cu/Zn-SOD significantly (
p
< 0.05), which were all opposite to the effects of ZnPP IX microinjected in PVN (
p
< 0.05). We concluded that exogenous or endogenous CO attenuates high salt-induced hypertension by regulating PICs and oxidative stress in PVN.</description><identifier>ISSN: 1530-7905</identifier><identifier>EISSN: 1559-0259</identifier><identifier>DOI: 10.1007/s12012-019-09517-w</identifier><identifier>PMID: 31037602</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adrenal glands ; Animals ; Anti-Inflammatory Agents - metabolism ; Anti-Inflammatory Agents - pharmacology ; Antihypertensive Agents - metabolism ; Antihypertensive Agents - pharmacology ; Antioxidants ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Arterial Pressure - drug effects ; Attenuation ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Carbon monoxide ; Carbon Monoxide - metabolism ; Carbon Monoxide - pharmacology ; Cardiology ; Copper ; CYBB protein ; Cyclooxygenase 2 - metabolism ; Cyclooxygenase-2 ; Cytokines ; Cytokines - metabolism ; Diet ; Disease Models, Animal ; Heme ; Heme oxygenase (decyclizing) ; Heme Oxygenase (Decyclizing) - metabolism ; Hypertension ; Hypertension - metabolism ; Hypertension - physiopathology ; Hypertension - prevention & control ; Hypothalamus ; IL-1β ; Inflammation ; Inflammation Mediators - metabolism ; Interleukin 6 ; Male ; Microinjection ; Norepinephrine ; NOX4 protein ; Organometallic Compounds - metabolism ; Organometallic Compounds - pharmacology ; Oxidative stress ; Oxidative Stress - drug effects ; Oxygenase ; Paraventricular Hypothalamic Nucleus - drug effects ; Paraventricular Hypothalamic Nucleus - metabolism ; Paraventricular Hypothalamic Nucleus - physiopathology ; Paraventricular nucleus ; Pharmacology/Toxicology ; Rats, Inbred Dahl ; Reactive oxygen species ; Salts ; Sodium chloride ; Sodium Chloride, Dietary ; Zinc</subject><ispartof>Cardiovascular toxicology, 2019-10, Vol.19 (5), p.451-464</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Cardiovascular Toxicology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-73d0a1a0517db4a9ad483b9ef5f4c3b815cd8f04110663cb9f52a4b485b5c3753</citedby><cites>FETCH-LOGICAL-c552t-73d0a1a0517db4a9ad483b9ef5f4c3b815cd8f04110663cb9f52a4b485b5c3753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12012-019-09517-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12012-019-09517-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31037602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Dong-Dong</creatorcontrib><creatorcontrib>Liang, Yan-Feng</creatorcontrib><creatorcontrib>Qi, Jie</creatorcontrib><creatorcontrib>Kang, Kai B.</creatorcontrib><creatorcontrib>Yu, Xiao-Jing</creatorcontrib><creatorcontrib>Gao, Hong-Li</creatorcontrib><creatorcontrib>Liu, Kai-Li</creatorcontrib><creatorcontrib>Chen, Yan-Mei</creatorcontrib><creatorcontrib>Shi, Xiao-Lian</creatorcontrib><creatorcontrib>Xin, Guo-Rui</creatorcontrib><creatorcontrib>Fu, Li-Yan</creatorcontrib><creatorcontrib>Kang, Yu-Ming</creatorcontrib><creatorcontrib>Cui, Wei</creatorcontrib><title>Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus</title><title>Cardiovascular toxicology</title><addtitle>Cardiovasc Toxicol</addtitle><addtitle>Cardiovasc Toxicol</addtitle><description>Carbon monoxide (CO) presents anti-inflammatory and antioxidant activities as a new gaseous neuromessenger produced by heme oxygenase-1 (HO-1) in the body. High salt-induced hypertension is relevant to the levels of pro-inflammatory cytokines (PICs) and oxidative stress in the hypothalamic paraventricular nucleus (PVN). We explored whether CO in PVN can attenuate high salt-induced hypertension by regulating PICs or oxidative stress. Male Dahl Salt-Sensitive rats were fed high-salt (8% NaCl) or normal-salt (0.3% NaCl) diet for 4 weeks. CORM-2, ZnPP IX, or vehicle was microinjected into bilateral PVN for 6 weeks. High-salt diet increased the levels of MAP, plasma norepinephrine (NE), reactive oxygen species (ROS), and the expressions of COX2, IL-1β, IL-6, NOX2, and NOX4 significantly in PVN (
p
< 0.05), but decreased the expressions of HO-1 and Cu/Zn-SOD in PVN (
p
< 0.05). Salt increased sympathetic activity as measured by circulating norepinephrine, and increased the ratio of basal RSNA to max RSNA, in part by decreasing max RSNA. PVN microinjection of CORM-2 decreased the levels of MAP, NE, RSNA, ROS and the expressions of COX2, IL-1β, IL-6, NOX2, NOX4 significantly in PVN of hypertensive rat (
p
< 0.05), but increased the expressions of HO-1 and Cu/Zn-SOD significantly (
p
< 0.05), which were all opposite to the effects of ZnPP IX microinjected in PVN (
p
< 0.05). We concluded that exogenous or endogenous CO attenuates high salt-induced hypertension by regulating PICs and oxidative stress in PVN.</description><subject>Adrenal glands</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - metabolism</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antihypertensive Agents - metabolism</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Arterial Pressure - drug effects</subject><subject>Attenuation</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Carbon monoxide</subject><subject>Carbon Monoxide - metabolism</subject><subject>Carbon Monoxide - pharmacology</subject><subject>Cardiology</subject><subject>Copper</subject><subject>CYBB protein</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Cyclooxygenase-2</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Diet</subject><subject>Disease Models, Animal</subject><subject>Heme</subject><subject>Heme oxygenase (decyclizing)</subject><subject>Heme Oxygenase (Decyclizing) - metabolism</subject><subject>Hypertension</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension - prevention & control</subject><subject>Hypothalamus</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Inflammation Mediators - metabolism</subject><subject>Interleukin 6</subject><subject>Male</subject><subject>Microinjection</subject><subject>Norepinephrine</subject><subject>NOX4 protein</subject><subject>Organometallic Compounds - metabolism</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxygenase</subject><subject>Paraventricular Hypothalamic Nucleus - drug effects</subject><subject>Paraventricular Hypothalamic Nucleus - metabolism</subject><subject>Paraventricular Hypothalamic Nucleus - physiopathology</subject><subject>Paraventricular nucleus</subject><subject>Pharmacology/Toxicology</subject><subject>Rats, Inbred Dahl</subject><subject>Reactive oxygen species</subject><subject>Salts</subject><subject>Sodium chloride</subject><subject>Sodium Chloride, Dietary</subject><subject>Zinc</subject><issn>1530-7905</issn><issn>1559-0259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9Ustu1DAUjRCIPuAHWCBLbNik-BHHyXI0AqZSoRUFsbQc-2bGJbGnttN2voTfxWEKFQghL2zrPHzv9SmKFwSfEIzFm0goJrTEpC1xy4kobx8Vh4TzfKW8fTyfGS5Fi_lBcRTjFcaU0po_LQ4YwUzUmB4W35cqdN6hD975O2sALVICN6kEEa3seoMu1ZDKU2cmDQatdlsIGY82S75u7ADoE2TIujW6CL60rh_UOKrkww4td8l_sy4bKWfQeXZXyd4AukwBYkTWobQBdKGCugGXgtXToAL6OOkBpviseNKrIcLz-_24-PLu7eflqjw7f3-6XJyVmnOaSsEMVkTh3L3pKtUqUzWsa6HnfaVZ1xCuTdPjihBc10x3bc-pqrqq4R3XTHB2XLze-26Dv54gJjnaqGEYlAM_RUkpEZVgpKkz9dVf1Cs_BZerm1k1b6gg1QNrrQaQeSA-BaVnU7kQpMFt29Tzsyf_YOVlYLTaO-jzbP8U0L1ABx9jgF5ugx1V2EmC5ZwGuU-DzGmQP9Mgb7Po5X3FUzeC-S359f2ZwPaEmCG3hvDQ0n9sfwBYA8D_</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Zhang, Dong-Dong</creator><creator>Liang, Yan-Feng</creator><creator>Qi, Jie</creator><creator>Kang, Kai B.</creator><creator>Yu, Xiao-Jing</creator><creator>Gao, Hong-Li</creator><creator>Liu, Kai-Li</creator><creator>Chen, Yan-Mei</creator><creator>Shi, Xiao-Lian</creator><creator>Xin, Guo-Rui</creator><creator>Fu, Li-Yan</creator><creator>Kang, Yu-Ming</creator><creator>Cui, Wei</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20191001</creationdate><title>Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus</title><author>Zhang, Dong-Dong ; Liang, Yan-Feng ; Qi, Jie ; Kang, Kai B. ; Yu, Xiao-Jing ; Gao, Hong-Li ; Liu, Kai-Li ; Chen, Yan-Mei ; Shi, Xiao-Lian ; Xin, Guo-Rui ; Fu, Li-Yan ; Kang, Yu-Ming ; Cui, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-73d0a1a0517db4a9ad483b9ef5f4c3b815cd8f04110663cb9f52a4b485b5c3753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adrenal glands</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - metabolism</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antihypertensive Agents - metabolism</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Arterial Pressure - drug effects</topic><topic>Attenuation</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Carbon monoxide</topic><topic>Carbon Monoxide - metabolism</topic><topic>Carbon Monoxide - pharmacology</topic><topic>Cardiology</topic><topic>Copper</topic><topic>CYBB protein</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Cyclooxygenase-2</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Diet</topic><topic>Disease Models, Animal</topic><topic>Heme</topic><topic>Heme oxygenase (decyclizing)</topic><topic>Heme Oxygenase (Decyclizing) - metabolism</topic><topic>Hypertension</topic><topic>Hypertension - metabolism</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension - prevention & control</topic><topic>Hypothalamus</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Inflammation Mediators - metabolism</topic><topic>Interleukin 6</topic><topic>Male</topic><topic>Microinjection</topic><topic>Norepinephrine</topic><topic>NOX4 protein</topic><topic>Organometallic Compounds - metabolism</topic><topic>Organometallic Compounds - pharmacology</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxygenase</topic><topic>Paraventricular Hypothalamic Nucleus - drug effects</topic><topic>Paraventricular Hypothalamic Nucleus - metabolism</topic><topic>Paraventricular Hypothalamic Nucleus - physiopathology</topic><topic>Paraventricular nucleus</topic><topic>Pharmacology/Toxicology</topic><topic>Rats, Inbred Dahl</topic><topic>Reactive oxygen species</topic><topic>Salts</topic><topic>Sodium chloride</topic><topic>Sodium Chloride, Dietary</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Dong-Dong</creatorcontrib><creatorcontrib>Liang, Yan-Feng</creatorcontrib><creatorcontrib>Qi, Jie</creatorcontrib><creatorcontrib>Kang, Kai B.</creatorcontrib><creatorcontrib>Yu, Xiao-Jing</creatorcontrib><creatorcontrib>Gao, Hong-Li</creatorcontrib><creatorcontrib>Liu, Kai-Li</creatorcontrib><creatorcontrib>Chen, Yan-Mei</creatorcontrib><creatorcontrib>Shi, Xiao-Lian</creatorcontrib><creatorcontrib>Xin, Guo-Rui</creatorcontrib><creatorcontrib>Fu, Li-Yan</creatorcontrib><creatorcontrib>Kang, Yu-Ming</creatorcontrib><creatorcontrib>Cui, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Dong-Dong</au><au>Liang, Yan-Feng</au><au>Qi, Jie</au><au>Kang, Kai B.</au><au>Yu, Xiao-Jing</au><au>Gao, Hong-Li</au><au>Liu, Kai-Li</au><au>Chen, Yan-Mei</au><au>Shi, Xiao-Lian</au><au>Xin, Guo-Rui</au><au>Fu, Li-Yan</au><au>Kang, Yu-Ming</au><au>Cui, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus</atitle><jtitle>Cardiovascular toxicology</jtitle><stitle>Cardiovasc Toxicol</stitle><addtitle>Cardiovasc Toxicol</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>19</volume><issue>5</issue><spage>451</spage><epage>464</epage><pages>451-464</pages><issn>1530-7905</issn><eissn>1559-0259</eissn><abstract>Carbon monoxide (CO) presents anti-inflammatory and antioxidant activities as a new gaseous neuromessenger produced by heme oxygenase-1 (HO-1) in the body. High salt-induced hypertension is relevant to the levels of pro-inflammatory cytokines (PICs) and oxidative stress in the hypothalamic paraventricular nucleus (PVN). We explored whether CO in PVN can attenuate high salt-induced hypertension by regulating PICs or oxidative stress. Male Dahl Salt-Sensitive rats were fed high-salt (8% NaCl) or normal-salt (0.3% NaCl) diet for 4 weeks. CORM-2, ZnPP IX, or vehicle was microinjected into bilateral PVN for 6 weeks. High-salt diet increased the levels of MAP, plasma norepinephrine (NE), reactive oxygen species (ROS), and the expressions of COX2, IL-1β, IL-6, NOX2, and NOX4 significantly in PVN (
p
< 0.05), but decreased the expressions of HO-1 and Cu/Zn-SOD in PVN (
p
< 0.05). Salt increased sympathetic activity as measured by circulating norepinephrine, and increased the ratio of basal RSNA to max RSNA, in part by decreasing max RSNA. PVN microinjection of CORM-2 decreased the levels of MAP, NE, RSNA, ROS and the expressions of COX2, IL-1β, IL-6, NOX2, NOX4 significantly in PVN of hypertensive rat (
p
< 0.05), but increased the expressions of HO-1 and Cu/Zn-SOD significantly (
p
< 0.05), which were all opposite to the effects of ZnPP IX microinjected in PVN (
p
< 0.05). We concluded that exogenous or endogenous CO attenuates high salt-induced hypertension by regulating PICs and oxidative stress in PVN.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31037602</pmid><doi>10.1007/s12012-019-09517-w</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1530-7905 |
| ispartof | Cardiovascular toxicology, 2019-10, Vol.19 (5), p.451-464 |
| issn | 1530-7905 1559-0259 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2217473186 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adrenal glands Animals Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Antihypertensive Agents - metabolism Antihypertensive Agents - pharmacology Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Arterial Pressure - drug effects Attenuation Biomedical and Life Sciences Biomedicine Brain Carbon monoxide Carbon Monoxide - metabolism Carbon Monoxide - pharmacology Cardiology Copper CYBB protein Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Cytokines - metabolism Diet Disease Models, Animal Heme Heme oxygenase (decyclizing) Heme Oxygenase (Decyclizing) - metabolism Hypertension Hypertension - metabolism Hypertension - physiopathology Hypertension - prevention & control Hypothalamus IL-1β Inflammation Inflammation Mediators - metabolism Interleukin 6 Male Microinjection Norepinephrine NOX4 protein Organometallic Compounds - metabolism Organometallic Compounds - pharmacology Oxidative stress Oxidative Stress - drug effects Oxygenase Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - metabolism Paraventricular Hypothalamic Nucleus - physiopathology Paraventricular nucleus Pharmacology/Toxicology Rats, Inbred Dahl Reactive oxygen species Salts Sodium chloride Sodium Chloride, Dietary Zinc |
| title | Carbon Monoxide Attenuates High Salt-Induced Hypertension While Reducing Pro-inflammatory Cytokines and Oxidative Stress in the Paraventricular Nucleus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T20%3A09%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Carbon%20Monoxide%20Attenuates%20High%20Salt-Induced%20Hypertension%20While%20Reducing%20Pro-inflammatory%20Cytokines%20and%20Oxidative%20Stress%20in%20the%20Paraventricular%20Nucleus&rft.jtitle=Cardiovascular%20toxicology&rft.au=Zhang,%20Dong-Dong&rft.date=2019-10-01&rft.volume=19&rft.issue=5&rft.spage=451&rft.epage=464&rft.pages=451-464&rft.issn=1530-7905&rft.eissn=1559-0259&rft_id=info:doi/10.1007/s12012-019-09517-w&rft_dat=%3Cgale_proqu%3EA718099865%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2216582714&rft_id=info:pmid/31037602&rft_galeid=A718099865&rfr_iscdi=true |