Neuroprotective and anti-inflammatory effects of isoliquiritigenin in kainic acid-induced epileptic rats via the TLR4/MYD88 signaling pathway

Epileptogenesis is a complex pathological process that occurs after an initial brain injury and involves a series of molecular events. Isoliquiritigenin (ISL), a flavonoid in licorice, is reported to have anti-inflammatory and antioxidant effects in various experimental models, but its specific role...

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Veröffentlicht in:	Inflammopharmacology 2019-12, Vol.27 (6), p.1143-1153
Hauptverfasser:	Zhu, Xiaobo, Liu, Jiankun, Chen, Ou, Xue, Jiang, Huang, Shanying, Zhu, Weiwei, Wang, Yibiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Animals Anti-Inflammatory Agents - pharmacology bcl-2-Associated X Protein - analysis Biomedical and Life Sciences Biomedicine Chalcones - pharmacology Cytokines - analysis Dermatology Epilepsy - drug therapy Epilepsy - physiopathology Gastroenterology Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Immunology Kainic Acid - pharmacology Microglia - drug effects Microglia - physiology Myeloid Differentiation Factor 88 - antagonists & inhibitors Myeloid Differentiation Factor 88 - physiology Neuroprotective Agents - pharmacology Original Article Pharmacology/Toxicology Rats Rats, Wistar Rheumatology Signal Transduction - physiology Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - physiology
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