Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism

Leishmania protozoans are the causative agent of leishmaniasis, a neglected tropical disease consisting of three major clinical forms: visceral leishmaniasis (VL), cutaneous leishmaniasis, and mucocutaneous leishmaniasis. VL is caused by Leishmania donovani in East Africa and the Indian subcontinent...

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Veröffentlicht in:	Amino acids 2020-02, Vol.52 (2), p.247-259
Hauptverfasser:	Colotti, Gianni, Saccoliti, Francesco, Gramiccia, Marina, Di Muccio, Trentina, Prakash, Jay, Yadav, Sunita, Dubey, Vikash Kumar, Vistoli, Giulio, Battista, Theo, Mocci, Stefano, Fiorillo, Annarita, Bibi, Aasia, Madia, Valentina Noemi, Messore, Antonella, Costi, Roberta, Di Santo, Roberto, Ilari, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Binding Biochemical Engineering Biochemistry Biomedical and Life Sciences Catalysis Chemical bonds Cutaneous leishmaniasis Enzymes Glutathione Glutathione reductase Homology Hydrogen bonding Hydrogen bonds Hydrogen peroxide Leishmania Life Sciences Macrophages Metabolism Mucocutaneous leishmaniasis Neurobiology Original Article Parasitic diseases Peroxidase Polyamines: Biochemical and Pathophysiological Properties Proteomics Reactive oxygen species Sulfide compounds Sulfides Tropical diseases Trypanothione Trypanothione reductase Tryparedoxin peroxidase Visceral leishmaniasis
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