Association between overweight or obesity and the risk for childhood asthma and wheeze: An updated meta‐analysis on 18 articles and 73 252 children
Summary Background Overweight or obesity is increasingly recognized as a possible risk factor for childhood asthma. Objectives We aimed to meta‐analyse the association between overweight or obesity and the risk for childhood asthma and wheeze and meanwhile explore potential causes of between‐study h...
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| Veröffentlicht in: | Pediatric obesity 2019-09, Vol.14 (9), p.e12532-n/a |
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| container_title | Pediatric obesity |
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| creator | Deng, Xiangling Ma, Jia Yuan, Yuan Zhang, Zhixin Niu, Wenquan |
| description | Summary
Background
Overweight or obesity is increasingly recognized as a possible risk factor for childhood asthma.
Objectives
We aimed to meta‐analyse the association between overweight or obesity and the risk for childhood asthma and wheeze and meanwhile explore potential causes of between‐study heterogeneity.
Methods
Literature search, study selection, and data extraction were performed independently and in duplicate. Data were analysed by STATA software.
Results
Eighteen articles and 73 252 children were analysed. In overall analyses, there was a significant association between overweight or obesity and the risk for childhood asthma (odds ratio [OR] = 1.30; 95% confidence interval [CI], 1.23‐1.39; P |
| doi_str_mv | 10.1111/ijpo.12532 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2216775992</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2268451055</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4232-927dfd115e9c5ed5ed814f5775770edfc269363a64731dce804387b02b8aaf713</originalsourceid><addsrcrecordid>eNp9kctqGzEUhkVoqY2TTR8gCLopASe6zDU7Y9ImweAs2vWgkc5k5MyMXEkT467yCFl1nWfpo_RJInvSLLLI4YAE59MnDj9Cnyk5paHO9GptTimLOTtAY0aidJpwSj683gkboSPnViRUQmhCok9oFAjOWZSP0Z-Zc0Zq4bXpcAl-A9Bhcw92A_q29thYbEpw2m-x6BT2NWCr3R2uwkDWulG1MQoL5-tW7IlNDfAbzvGsw_1aCQ8Kt-DFv4dH0Ylm67TD4SeaYWG9lg24_auU_31iMRuUFrpD9LESjYOjl3OCfn67-DG_nC6W36_ms8VURoyzac5SVSlKY8hlDCp0RqMqTtPQBFQlWZLzhIskSjlVEjIS8SwtCSszIaqU8gn6OnjX1vzqwfmi1U5C04gOTO8KxmgSbHnOAvrlDboyvQ077agki2JK4jhQJwMlrXHOQlWsrW6F3RaUFLvAil1gxT6wAB-_KPuyBfWK_o8nAHQANrqB7Tuq4ur6ZjlInwGQ0KGX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2268451055</pqid></control><display><type>article</type><title>Association between overweight or obesity and the risk for childhood asthma and wheeze: An updated meta‐analysis on 18 articles and 73 252 children</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Deng, Xiangling ; Ma, Jia ; Yuan, Yuan ; Zhang, Zhixin ; Niu, Wenquan</creator><creatorcontrib>Deng, Xiangling ; Ma, Jia ; Yuan, Yuan ; Zhang, Zhixin ; Niu, Wenquan</creatorcontrib><description>Summary
Background
Overweight or obesity is increasingly recognized as a possible risk factor for childhood asthma.
Objectives
We aimed to meta‐analyse the association between overweight or obesity and the risk for childhood asthma and wheeze and meanwhile explore potential causes of between‐study heterogeneity.
Methods
Literature search, study selection, and data extraction were performed independently and in duplicate. Data were analysed by STATA software.
Results
Eighteen articles and 73 252 children were analysed. In overall analyses, there was a significant association between overweight or obesity and the risk for childhood asthma (odds ratio [OR] = 1.30; 95% confidence interval [CI], 1.23‐1.39; P < 0.001) and wheeze (OR = 1.90; 95% CI, 1.38‐2.63; P < 0.001), with none/marginal publication bias as revealed by the Egger test (P = 0.938/0.038), respectively. Subgroup analyses showed that children with obesity (OR = 1.40; 95% CI, 1.29‐1.52) were more likely to have asthma than children with overweight (OR = 1.22; 95% CI, 1.14‐1.31), and in children with overweight or obesity, girls (OR = 1.34; 95% CI, 1.16‐1.56) were more likely to have asthma than boys (OR = 1.27; 95% CI, 1.15‐1.40).
Conclusions
Our findings indicate that overweight or obesity is a significant risk factor for childhood asthma and wheeze and in children with overweight or obesity, the risk is more evident in girls than in boys.</description><identifier>ISSN: 2047-6302</identifier><identifier>EISSN: 2047-6310</identifier><identifier>DOI: 10.1111/ijpo.12532</identifier><identifier>PMID: 31033249</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Asthma ; Asthma - complications ; Asthma - physiopathology ; Child ; Childhood ; children ; Childrens health ; Female ; Humans ; Male ; Meta-analysis ; Obesity ; overweight ; Overweight - complications ; Pediatric Obesity - complications ; Pediatric Obesity - physiopathology ; Pediatrics ; Respiratory Sounds - physiology ; Risk Factors</subject><ispartof>Pediatric obesity, 2019-09, Vol.14 (9), p.e12532-n/a</ispartof><rights>2019 World Obesity Federation</rights><rights>2019 World Obesity Federation.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4232-927dfd115e9c5ed5ed814f5775770edfc269363a64731dce804387b02b8aaf713</citedby><cites>FETCH-LOGICAL-c4232-927dfd115e9c5ed5ed814f5775770edfc269363a64731dce804387b02b8aaf713</cites><orcidid>0000-0003-1715-3372</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijpo.12532$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijpo.12532$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31033249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Xiangling</creatorcontrib><creatorcontrib>Ma, Jia</creatorcontrib><creatorcontrib>Yuan, Yuan</creatorcontrib><creatorcontrib>Zhang, Zhixin</creatorcontrib><creatorcontrib>Niu, Wenquan</creatorcontrib><title>Association between overweight or obesity and the risk for childhood asthma and wheeze: An updated meta‐analysis on 18 articles and 73 252 children</title><title>Pediatric obesity</title><addtitle>Pediatr Obes</addtitle><description>Summary
Background
Overweight or obesity is increasingly recognized as a possible risk factor for childhood asthma.
Objectives
We aimed to meta‐analyse the association between overweight or obesity and the risk for childhood asthma and wheeze and meanwhile explore potential causes of between‐study heterogeneity.
Methods
Literature search, study selection, and data extraction were performed independently and in duplicate. Data were analysed by STATA software.
Results
Eighteen articles and 73 252 children were analysed. In overall analyses, there was a significant association between overweight or obesity and the risk for childhood asthma (odds ratio [OR] = 1.30; 95% confidence interval [CI], 1.23‐1.39; P < 0.001) and wheeze (OR = 1.90; 95% CI, 1.38‐2.63; P < 0.001), with none/marginal publication bias as revealed by the Egger test (P = 0.938/0.038), respectively. Subgroup analyses showed that children with obesity (OR = 1.40; 95% CI, 1.29‐1.52) were more likely to have asthma than children with overweight (OR = 1.22; 95% CI, 1.14‐1.31), and in children with overweight or obesity, girls (OR = 1.34; 95% CI, 1.16‐1.56) were more likely to have asthma than boys (OR = 1.27; 95% CI, 1.15‐1.40).
Conclusions
Our findings indicate that overweight or obesity is a significant risk factor for childhood asthma and wheeze and in children with overweight or obesity, the risk is more evident in girls than in boys.</description><subject>Asthma</subject><subject>Asthma - complications</subject><subject>Asthma - physiopathology</subject><subject>Child</subject><subject>Childhood</subject><subject>children</subject><subject>Childrens health</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Obesity</subject><subject>overweight</subject><subject>Overweight - complications</subject><subject>Pediatric Obesity - complications</subject><subject>Pediatric Obesity - physiopathology</subject><subject>Pediatrics</subject><subject>Respiratory Sounds - physiology</subject><subject>Risk Factors</subject><issn>2047-6302</issn><issn>2047-6310</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctqGzEUhkVoqY2TTR8gCLopASe6zDU7Y9ImweAs2vWgkc5k5MyMXEkT467yCFl1nWfpo_RJInvSLLLI4YAE59MnDj9Cnyk5paHO9GptTimLOTtAY0aidJpwSj683gkboSPnViRUQmhCok9oFAjOWZSP0Z-Zc0Zq4bXpcAl-A9Bhcw92A_q29thYbEpw2m-x6BT2NWCr3R2uwkDWulG1MQoL5-tW7IlNDfAbzvGsw_1aCQ8Kt-DFv4dH0Ylm67TD4SeaYWG9lg24_auU_31iMRuUFrpD9LESjYOjl3OCfn67-DG_nC6W36_ms8VURoyzac5SVSlKY8hlDCp0RqMqTtPQBFQlWZLzhIskSjlVEjIS8SwtCSszIaqU8gn6OnjX1vzqwfmi1U5C04gOTO8KxmgSbHnOAvrlDboyvQ077agki2JK4jhQJwMlrXHOQlWsrW6F3RaUFLvAil1gxT6wAB-_KPuyBfWK_o8nAHQANrqB7Tuq4ur6ZjlInwGQ0KGX</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Deng, Xiangling</creator><creator>Ma, Jia</creator><creator>Yuan, Yuan</creator><creator>Zhang, Zhixin</creator><creator>Niu, Wenquan</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1715-3372</orcidid></search><sort><creationdate>201909</creationdate><title>Association between overweight or obesity and the risk for childhood asthma and wheeze: An updated meta‐analysis on 18 articles and 73 252 children</title><author>Deng, Xiangling ; Ma, Jia ; Yuan, Yuan ; Zhang, Zhixin ; Niu, Wenquan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4232-927dfd115e9c5ed5ed814f5775770edfc269363a64731dce804387b02b8aaf713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Asthma</topic><topic>Asthma - complications</topic><topic>Asthma - physiopathology</topic><topic>Child</topic><topic>Childhood</topic><topic>children</topic><topic>Childrens health</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Obesity</topic><topic>overweight</topic><topic>Overweight - complications</topic><topic>Pediatric Obesity - complications</topic><topic>Pediatric Obesity - physiopathology</topic><topic>Pediatrics</topic><topic>Respiratory Sounds - physiology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Xiangling</creatorcontrib><creatorcontrib>Ma, Jia</creatorcontrib><creatorcontrib>Yuan, Yuan</creatorcontrib><creatorcontrib>Zhang, Zhixin</creatorcontrib><creatorcontrib>Niu, Wenquan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Xiangling</au><au>Ma, Jia</au><au>Yuan, Yuan</au><au>Zhang, Zhixin</au><au>Niu, Wenquan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between overweight or obesity and the risk for childhood asthma and wheeze: An updated meta‐analysis on 18 articles and 73 252 children</atitle><jtitle>Pediatric obesity</jtitle><addtitle>Pediatr Obes</addtitle><date>2019-09</date><risdate>2019</risdate><volume>14</volume><issue>9</issue><spage>e12532</spage><epage>n/a</epage><pages>e12532-n/a</pages><issn>2047-6302</issn><eissn>2047-6310</eissn><abstract>Summary
Background
Overweight or obesity is increasingly recognized as a possible risk factor for childhood asthma.
Objectives
We aimed to meta‐analyse the association between overweight or obesity and the risk for childhood asthma and wheeze and meanwhile explore potential causes of between‐study heterogeneity.
Methods
Literature search, study selection, and data extraction were performed independently and in duplicate. Data were analysed by STATA software.
Results
Eighteen articles and 73 252 children were analysed. In overall analyses, there was a significant association between overweight or obesity and the risk for childhood asthma (odds ratio [OR] = 1.30; 95% confidence interval [CI], 1.23‐1.39; P < 0.001) and wheeze (OR = 1.90; 95% CI, 1.38‐2.63; P < 0.001), with none/marginal publication bias as revealed by the Egger test (P = 0.938/0.038), respectively. Subgroup analyses showed that children with obesity (OR = 1.40; 95% CI, 1.29‐1.52) were more likely to have asthma than children with overweight (OR = 1.22; 95% CI, 1.14‐1.31), and in children with overweight or obesity, girls (OR = 1.34; 95% CI, 1.16‐1.56) were more likely to have asthma than boys (OR = 1.27; 95% CI, 1.15‐1.40).
Conclusions
Our findings indicate that overweight or obesity is a significant risk factor for childhood asthma and wheeze and in children with overweight or obesity, the risk is more evident in girls than in boys.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31033249</pmid><doi>10.1111/ijpo.12532</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-1715-3372</orcidid></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Asthma Asthma - complications Asthma - physiopathology Child Childhood children Childrens health Female Humans Male Meta-analysis Obesity overweight Overweight - complications Pediatric Obesity - complications Pediatric Obesity - physiopathology Pediatrics Respiratory Sounds - physiology Risk Factors |
| title | Association between overweight or obesity and the risk for childhood asthma and wheeze: An updated meta‐analysis on 18 articles and 73 252 children |
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