Abrogation of myofibroblast activities in metastasis and fibrosis by methyltransferase inhibition

Myofibroblasts are a population of highly contractile fibroblasts that express and require the activity of the transcription factor Snail1. Cancer‐associated fibroblasts (CAFs) correlate with low survival of cancer patients when present in the stroma of primary tumors. Remarkably, the presence of my...

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Veröffentlicht in:	International journal of cancer 2019-12, Vol.145 (11), p.3064-3077
Hauptverfasser:	Sala, Laura, Franco‐Valls, Héctor, Stanisavljevic, Jelena, Curto, Josue, Vergés, Jordi, Peña, Raúl, Duch, Paula, Alcaraz, Jordi, García de Herreros, Antonio, Baulida, Josep
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - administration & dosage Adenosine - analogs & derivatives Adenosine - pharmacology Animal models Animals Arginine Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Cancer Cancer-Associated Fibroblasts - cytology Cancer-Associated Fibroblasts - drug effects Cancer-Associated Fibroblasts - metabolism Cell culture Cell Line, Tumor Cell Transdifferentiation Cells, Cultured Contractility Disease Models, Animal Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Epigenesis, Genetic Epigenetics Extracellular matrix Female Fibroblasts Fibrosis Gene Deletion Humans Idiopathic Pulmonary Fibrosis - drug therapy Idiopathic Pulmonary Fibrosis - enzymology Inhibitors Lung diseases Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - secondary Mechanical properties Medical research Metastases Metastasis Methyltransferase methyltransferase inhibitors Methyltransferases - antagonists & inhibitors Methyltransferases - genetics Mice myofibroblast Myofibroblasts - cytology Myofibroblasts - drug effects Myofibroblasts - enzymology Reagents Snail Family Transcription Factors - genetics Snail Family Transcription Factors - metabolism Snail1 Stroma Transforming Growth Factor beta - metabolism Tumor Microenvironment Tumors Wound healing Xenograft Model Antitumor Assays
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