Comparison of the levels of the serotonin metabolite, 5-hydroxyindole acetic acid, in cerebrospinal fluid from patients with and without premature ejaculation
Premature ejaculation (PE) is a significant problem as it can cause a loss of sexual self-confidence and a significant deterioration in quality of life. The frequency of PE varies between 9% and 27%. In the current study, we aimed to compare the levels of the serotonin metabolite 5HIAA (5 hydroxyind...
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| creator | Erdogan, Abdullah Demirbas, Murat Oner, Sedat Aydos, Mustafa Murat Sambel, Murat Yilmaz, Canan |
| description | Premature ejaculation (PE) is a significant problem as it can cause a loss of sexual self-confidence and a significant deterioration in quality of life. The frequency of PE varies between 9% and 27%. In the current study, we aimed to compare the levels of the serotonin metabolite 5HIAA (5 hydroxyindole acetic acid) in the cerebrospinal fluid (CSF) of patients with and without PE according to IELT (intravaginal ejaculation latency time) in order to investigate the relationship of PE with CSF 5HIAA levels.
A total of 60 male patients were included in the study who were planning to undergo surgery under spinal anesthesia, 30 in the patient (PE) group (all of the included patients had an IELT of 1min). Levels of CSF 5HIAA were measured.
There was a significant negative correlation between IELT and the 5HIAA variables in all patients (r=−0.322, p=0.012). Although the average 5HIAA levels (nmol/L) were higher in the patient group (86.80±28.33) than in the control group (76.44±35.91), this difference was not significant (p=0.22).
Results of the current study bring new and different perspectives to the explanation of PE pathophysiology. There is a need for more specific and genetic studies to determine the best treatment for this common disorder.
La eyaculación precoz (EP) es un problema importante, ya que puede provocar una pérdida de confianza sexual en uno mismo y un deterioro considerable de la calidad de vida. La frecuencia de EP varía entre el 9 y el 27%. En este estudio, nuestro objetivo fue comparar los niveles del ácido 5-hidroxindolacético (5-HIAA), metabolito de la serotonina, en el líquido cefalorraquídeo (LCR) de pacientes con y sin EP según el tiempo de latencia eyaculatoria intravaginal (TLEI) para analizar la relación de la EP con los niveles de 5-HIAA en el LCR.
Se incluyeron en el estudio un total de 60 pacientes de sexo masculino que tenían prevista cirugía con anestesia intradural, 30 en el grupo de pacientes con EP (todos los pacientes incluidos tenían un TLEI 1 min). Se midieron los niveles de 5-HIAA en el LCR.
Hubo una correlación negativa importante entre las variables TLEI y 5-HIAA en todos los pacientes (r=−0,322; p=0,012). Aunque los niveles medios de 5-HIAA (nmol/l) fueron más elevados en el grupo de pacientes (86,80±28,33) que en el grupo de control (76,44±35,91), esta diferencia no fue considerable (p=0,22).
L |
| doi_str_mv | 10.1016/j.androl.2018.01.001 |
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A total of 60 male patients were included in the study who were planning to undergo surgery under spinal anesthesia, 30 in the patient (PE) group (all of the included patients had an IELT of <1min) and 30 in the control group (patients had an IELT of >1min). Levels of CSF 5HIAA were measured.
There was a significant negative correlation between IELT and the 5HIAA variables in all patients (r=−0.322, p=0.012). Although the average 5HIAA levels (nmol/L) were higher in the patient group (86.80±28.33) than in the control group (76.44±35.91), this difference was not significant (p=0.22).
Results of the current study bring new and different perspectives to the explanation of PE pathophysiology. There is a need for more specific and genetic studies to determine the best treatment for this common disorder.
La eyaculación precoz (EP) es un problema importante, ya que puede provocar una pérdida de confianza sexual en uno mismo y un deterioro considerable de la calidad de vida. La frecuencia de EP varía entre el 9 y el 27%. En este estudio, nuestro objetivo fue comparar los niveles del ácido 5-hidroxindolacético (5-HIAA), metabolito de la serotonina, en el líquido cefalorraquídeo (LCR) de pacientes con y sin EP según el tiempo de latencia eyaculatoria intravaginal (TLEI) para analizar la relación de la EP con los niveles de 5-HIAA en el LCR.
Se incluyeron en el estudio un total de 60 pacientes de sexo masculino que tenían prevista cirugía con anestesia intradural, 30 en el grupo de pacientes con EP (todos los pacientes incluidos tenían un TLEI <1min) y 30 en el grupo de control (los pacientes tenían un TLEI >1 min). Se midieron los niveles de 5-HIAA en el LCR.
Hubo una correlación negativa importante entre las variables TLEI y 5-HIAA en todos los pacientes (r=−0,322; p=0,012). Aunque los niveles medios de 5-HIAA (nmol/l) fueron más elevados en el grupo de pacientes (86,80±28,33) que en el grupo de control (76,44±35,91), esta diferencia no fue considerable (p=0,22).
Los resultados del presente estudio aportaron nuevas y diferentes perspectivas a la explicación de la fisiopatología de la EP. Es necesario realizar más estudios específicos y genéticos para establecer el mejor tratamiento de este trastorno frecuente.</description><identifier>ISSN: 1698-031X</identifier><identifier>EISSN: 1698-0409</identifier><identifier>DOI: 10.1016/j.androl.2018.01.001</identifier><identifier>PMID: 31029436</identifier><language>eng</language><publisher>Spain: Elsevier España, S.L.U</publisher><subject>5-Hydroxyindol acetic acid levels ; Adult ; Cerebrospinal fluid ; Eyaculación precoz ; Humans ; Hydroxyindoleacetic Acid - cerebrospinal fluid ; Líquido cefalorraquídeo ; Male ; Niveles de ácido 5-hidroxindolacético ; Premature ejaculation ; Premature Ejaculation - cerebrospinal fluid ; Premature Ejaculation - metabolism ; Serotonin - metabolism</subject><ispartof>Revista internacional de andrologia, 2019-04, Vol.17 (2), p.41-45</ispartof><rights>2018 Asociación Española de Andrología, Medicina Sexual y Reproductiva</rights><rights>Copyright © 2018 Asociación Española de Andrología, Medicina Sexual y Reproductiva. Publicado por Elsevier España, S.L.U. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-3b6b18bf1dcf3d3dea5eeccfb92abfe80767ff4a0a6f2da6d5a09d87ad7ef0533</citedby><cites>FETCH-LOGICAL-c362t-3b6b18bf1dcf3d3dea5eeccfb92abfe80767ff4a0a6f2da6d5a09d87ad7ef0533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.androl.2018.01.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31029436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erdogan, Abdullah</creatorcontrib><creatorcontrib>Demirbas, Murat</creatorcontrib><creatorcontrib>Oner, Sedat</creatorcontrib><creatorcontrib>Aydos, Mustafa Murat</creatorcontrib><creatorcontrib>Sambel, Murat</creatorcontrib><creatorcontrib>Yilmaz, Canan</creatorcontrib><title>Comparison of the levels of the serotonin metabolite, 5-hydroxyindole acetic acid, in cerebrospinal fluid from patients with and without premature ejaculation</title><title>Revista internacional de andrologia</title><addtitle>Rev Int Androl</addtitle><description>Premature ejaculation (PE) is a significant problem as it can cause a loss of sexual self-confidence and a significant deterioration in quality of life. The frequency of PE varies between 9% and 27%. In the current study, we aimed to compare the levels of the serotonin metabolite 5HIAA (5 hydroxyindole acetic acid) in the cerebrospinal fluid (CSF) of patients with and without PE according to IELT (intravaginal ejaculation latency time) in order to investigate the relationship of PE with CSF 5HIAA levels.
A total of 60 male patients were included in the study who were planning to undergo surgery under spinal anesthesia, 30 in the patient (PE) group (all of the included patients had an IELT of <1min) and 30 in the control group (patients had an IELT of >1min). Levels of CSF 5HIAA were measured.
There was a significant negative correlation between IELT and the 5HIAA variables in all patients (r=−0.322, p=0.012). Although the average 5HIAA levels (nmol/L) were higher in the patient group (86.80±28.33) than in the control group (76.44±35.91), this difference was not significant (p=0.22).
Results of the current study bring new and different perspectives to the explanation of PE pathophysiology. There is a need for more specific and genetic studies to determine the best treatment for this common disorder.
La eyaculación precoz (EP) es un problema importante, ya que puede provocar una pérdida de confianza sexual en uno mismo y un deterioro considerable de la calidad de vida. La frecuencia de EP varía entre el 9 y el 27%. En este estudio, nuestro objetivo fue comparar los niveles del ácido 5-hidroxindolacético (5-HIAA), metabolito de la serotonina, en el líquido cefalorraquídeo (LCR) de pacientes con y sin EP según el tiempo de latencia eyaculatoria intravaginal (TLEI) para analizar la relación de la EP con los niveles de 5-HIAA en el LCR.
Se incluyeron en el estudio un total de 60 pacientes de sexo masculino que tenían prevista cirugía con anestesia intradural, 30 en el grupo de pacientes con EP (todos los pacientes incluidos tenían un TLEI <1min) y 30 en el grupo de control (los pacientes tenían un TLEI >1 min). Se midieron los niveles de 5-HIAA en el LCR.
Hubo una correlación negativa importante entre las variables TLEI y 5-HIAA en todos los pacientes (r=−0,322; p=0,012). Aunque los niveles medios de 5-HIAA (nmol/l) fueron más elevados en el grupo de pacientes (86,80±28,33) que en el grupo de control (76,44±35,91), esta diferencia no fue considerable (p=0,22).
Los resultados del presente estudio aportaron nuevas y diferentes perspectivas a la explicación de la fisiopatología de la EP. Es necesario realizar más estudios específicos y genéticos para establecer el mejor tratamiento de este trastorno frecuente.</description><subject>5-Hydroxyindol acetic acid levels</subject><subject>Adult</subject><subject>Cerebrospinal fluid</subject><subject>Eyaculación precoz</subject><subject>Humans</subject><subject>Hydroxyindoleacetic Acid - cerebrospinal fluid</subject><subject>Líquido cefalorraquídeo</subject><subject>Male</subject><subject>Niveles de ácido 5-hidroxindolacético</subject><subject>Premature ejaculation</subject><subject>Premature Ejaculation - cerebrospinal fluid</subject><subject>Premature Ejaculation - metabolism</subject><subject>Serotonin - metabolism</subject><issn>1698-031X</issn><issn>1698-0409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-KFDEQhxtR3D_6BiI5ethuK53udPdFkEFXYcGLgreQTipMhnTSJunVeRmf1ayz49FTVeCr_Kj6quoVhYYC5W8PjfQ6Bte0QMcGaANAn1SXlE9jDR1MT889o98vqquUDgCcsw6eVxeMQjt1jF9Wv3dhWWW0KXgSDMl7JA7v0aXzK2EMOXjryYJZzsHZjDekr_fHEv7raL0ODolUmK0qxeobUliFEecY0mq9dMS4zWpiYljIKrNFnxP5afOelA3-NmHLZI24yLxFJHiQanMFDP5F9cxIl_DlY72uvn388HX3qb77cvt59_6uVoy3uWYzn-k4G6qVYZpplD2iUmaeWjkbHGHggzGdBMlNqyXXvYRJj4PUAxroGbuu3pz-XWP4sWHKYrFJoXPSY9iSaFvKh6Ed-q6g3QlVZb8U0Yg12kXGo6AgHsyIgziZEQ9mBFBRzJSx148J27yg_jd0VlGAdyegHB_vLUaRVDmVQm0jqix0sP9P-AO0IqcX</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Erdogan, Abdullah</creator><creator>Demirbas, Murat</creator><creator>Oner, Sedat</creator><creator>Aydos, Mustafa Murat</creator><creator>Sambel, Murat</creator><creator>Yilmaz, Canan</creator><general>Elsevier España, S.L.U</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201904</creationdate><title>Comparison of the levels of the serotonin metabolite, 5-hydroxyindole acetic acid, in cerebrospinal fluid from patients with and without premature ejaculation</title><author>Erdogan, Abdullah ; Demirbas, Murat ; Oner, Sedat ; Aydos, Mustafa Murat ; Sambel, Murat ; Yilmaz, Canan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-3b6b18bf1dcf3d3dea5eeccfb92abfe80767ff4a0a6f2da6d5a09d87ad7ef0533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>5-Hydroxyindol acetic acid levels</topic><topic>Adult</topic><topic>Cerebrospinal fluid</topic><topic>Eyaculación precoz</topic><topic>Humans</topic><topic>Hydroxyindoleacetic Acid - cerebrospinal fluid</topic><topic>Líquido cefalorraquídeo</topic><topic>Male</topic><topic>Niveles de ácido 5-hidroxindolacético</topic><topic>Premature ejaculation</topic><topic>Premature Ejaculation - cerebrospinal fluid</topic><topic>Premature Ejaculation - metabolism</topic><topic>Serotonin - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Erdogan, Abdullah</creatorcontrib><creatorcontrib>Demirbas, Murat</creatorcontrib><creatorcontrib>Oner, Sedat</creatorcontrib><creatorcontrib>Aydos, Mustafa Murat</creatorcontrib><creatorcontrib>Sambel, Murat</creatorcontrib><creatorcontrib>Yilmaz, Canan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Revista internacional de andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erdogan, Abdullah</au><au>Demirbas, Murat</au><au>Oner, Sedat</au><au>Aydos, Mustafa Murat</au><au>Sambel, Murat</au><au>Yilmaz, Canan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the levels of the serotonin metabolite, 5-hydroxyindole acetic acid, in cerebrospinal fluid from patients with and without premature ejaculation</atitle><jtitle>Revista internacional de andrologia</jtitle><addtitle>Rev Int Androl</addtitle><date>2019-04</date><risdate>2019</risdate><volume>17</volume><issue>2</issue><spage>41</spage><epage>45</epage><pages>41-45</pages><issn>1698-031X</issn><eissn>1698-0409</eissn><abstract>Premature ejaculation (PE) is a significant problem as it can cause a loss of sexual self-confidence and a significant deterioration in quality of life. The frequency of PE varies between 9% and 27%. In the current study, we aimed to compare the levels of the serotonin metabolite 5HIAA (5 hydroxyindole acetic acid) in the cerebrospinal fluid (CSF) of patients with and without PE according to IELT (intravaginal ejaculation latency time) in order to investigate the relationship of PE with CSF 5HIAA levels.
A total of 60 male patients were included in the study who were planning to undergo surgery under spinal anesthesia, 30 in the patient (PE) group (all of the included patients had an IELT of <1min) and 30 in the control group (patients had an IELT of >1min). Levels of CSF 5HIAA were measured.
There was a significant negative correlation between IELT and the 5HIAA variables in all patients (r=−0.322, p=0.012). Although the average 5HIAA levels (nmol/L) were higher in the patient group (86.80±28.33) than in the control group (76.44±35.91), this difference was not significant (p=0.22).
Results of the current study bring new and different perspectives to the explanation of PE pathophysiology. There is a need for more specific and genetic studies to determine the best treatment for this common disorder.
La eyaculación precoz (EP) es un problema importante, ya que puede provocar una pérdida de confianza sexual en uno mismo y un deterioro considerable de la calidad de vida. La frecuencia de EP varía entre el 9 y el 27%. En este estudio, nuestro objetivo fue comparar los niveles del ácido 5-hidroxindolacético (5-HIAA), metabolito de la serotonina, en el líquido cefalorraquídeo (LCR) de pacientes con y sin EP según el tiempo de latencia eyaculatoria intravaginal (TLEI) para analizar la relación de la EP con los niveles de 5-HIAA en el LCR.
Se incluyeron en el estudio un total de 60 pacientes de sexo masculino que tenían prevista cirugía con anestesia intradural, 30 en el grupo de pacientes con EP (todos los pacientes incluidos tenían un TLEI <1min) y 30 en el grupo de control (los pacientes tenían un TLEI >1 min). Se midieron los niveles de 5-HIAA en el LCR.
Hubo una correlación negativa importante entre las variables TLEI y 5-HIAA en todos los pacientes (r=−0,322; p=0,012). Aunque los niveles medios de 5-HIAA (nmol/l) fueron más elevados en el grupo de pacientes (86,80±28,33) que en el grupo de control (76,44±35,91), esta diferencia no fue considerable (p=0,22).
Los resultados del presente estudio aportaron nuevas y diferentes perspectivas a la explicación de la fisiopatología de la EP. Es necesario realizar más estudios específicos y genéticos para establecer el mejor tratamiento de este trastorno frecuente.</abstract><cop>Spain</cop><pub>Elsevier España, S.L.U</pub><pmid>31029436</pmid><doi>10.1016/j.androl.2018.01.001</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1698-031X |
| ispartof | Revista internacional de andrologia, 2019-04, Vol.17 (2), p.41-45 |
| issn | 1698-031X 1698-0409 |
| language | eng |
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| subjects | 5-Hydroxyindol acetic acid levels Adult Cerebrospinal fluid Eyaculación precoz Humans Hydroxyindoleacetic Acid - cerebrospinal fluid Líquido cefalorraquídeo Male Niveles de ácido 5-hidroxindolacético Premature ejaculation Premature Ejaculation - cerebrospinal fluid Premature Ejaculation - metabolism Serotonin - metabolism |
| title | Comparison of the levels of the serotonin metabolite, 5-hydroxyindole acetic acid, in cerebrospinal fluid from patients with and without premature ejaculation |
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