Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts

Oxidative stress is known to induce early replicative senescence. Senescence has been proposed to work as a barrier to immortalization and tumor development. Here, we aimed to evaluate the impact of the loss of peroxisome proliferator activated receptor γ co-activator 1α (PGC-1α), a master regulator...

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Veröffentlicht in:	Free radical biology & medicine 2019-07, Vol.138, p.23-32
Hauptverfasser:	Prieto, Ignacio, Zambrano, Alberto, Laso, Javier, Aranda, Ana, Samper, Enrique, Monsalve, María
Format:	Artikel
Sprache:	eng
Schlagworte:	Immortalization Mitochondria Oxidative stress PGC-1α Senescence
Online-Zugang:	Volltext
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