Engineering a multifunctional 3D-printed PLA-collagen-minocycline-nanoHydroxyapatite scaffold with combined antimicrobial and osteogenic effects for bone regeneration

3D-printing and additive manufacturing can be powerful techniques to design customized structures and produce synthetic bone grafts with multifunctional effects suitable for bone repair. In our work we aimed the development of novel multifunctionalized 3D printed poly(lactic acid) (PLA) scaffolds wi...

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Veröffentlicht in:	Materials Science & Engineering C 2019-08, Vol.101, p.15-26
Hauptverfasser:	Martin, Victor, Ribeiro, Isabel A., Alves, Marta M., Gonçalves, Lídia, Claudio, Ricardo A., Grenho, Liliana, Fernandes, Maria H., Gomes, Pedro, Santos, Catarina F., Bettencourt, Ana F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Additive manufacturing Adsorption Anti-Bacterial Agents - pharmacology Antibiofilm Antibiotics Biocompatibility Biofilms Biofilms - drug effects Biomimetics Bone growth Bone healing Bone implants Bone marrow Bone regeneration Bone Regeneration - drug effects Cbfa-1 protein Citric acid Collagen Collagen - pharmacology Compressive strength Drug delivery Drug delivery systems Drug Liberation Durapatite - pharmacology Gene expression Gene Expression Regulation - drug effects Grafts Humans Hydroxyapatite Local-drug-delivery Materials science Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Mesenchymal Stem Cells - ultrastructure Mesenchyme Microbial Sensitivity Tests Minocycline Minocycline - pharmacology Nanoparticles Nanoparticles - chemistry Osseointegration - drug effects Osteogenesis Osteogenesis - drug effects Osteogenesis - genetics Polyesters - pharmacology Polylactic acid Printing, Three-Dimensional Regeneration Regeneration (physiology) Repair Scaffolds Staphylococcus aureus Staphylococcus aureus - drug effects Stem cells Substitute bone Surgical implants Tetracyclines Three dimensional printing Tissue Engineering - methods Tissue Scaffolds - chemistry Wettability
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