A new immunohistochemical marker, insulinoma-associated protein 1 (INSM1), for Merkel cell carcinoma: Evaluation of 24 cases

Merkel cell carcinoma (MCC) is an uncommon primary neuroendocrine carcinoma of the skin. Nowadays, pathologists are required to perform immunohistochemistry to demonstrate neuroendocrine and epithelial differentiation for diagnosis of MCC. Insulinoma-associated protein 1 (INSM1) is a zinc-finger tra...

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Veröffentlicht in:	Annals of diagnostic pathology 2019-06, Vol.40, p.53-58
Hauptverfasser:	Leblebici, Cem, Yeni, Begüm, Savli, Taha Cumhan, Aydın, Övgü, Güneş, Pembegül, Cinel, Leyla, Şimşek, Bengü Çobanoğlu, Yıldız, Pelin, Tuncel, Deniz, Kayahan, Sibel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Carcinoma, Merkel Cell - metabolism Carcinoma, Merkel Cell - pathology Carcinoma, Neuroendocrine - metabolism Carcinoma, Neuroendocrine - pathology CD56 CD56 Antigen - metabolism Chromogranin Chromogranin A - metabolism Female Humans INSM1 Insulinoma - metabolism Insulinoma - pathology Male Merkel cell carcinoma Middle Aged Neuroendocrine carcinoma of the skin Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Repressor Proteins - metabolism Sensitivity and Specificity Skin Neoplasms - metabolism Skin Neoplasms - pathology Synaptophysin Synaptophysin - metabolism Transcription Factors - metabolism
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