The relationship between the PD-L1 expression of surgically resected and fine-needle aspiration specimens for patients with pancreatic cancer
Background Recently, therapeutic antibodies against programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) have shown promising clinical results for several solid tumors, including pancreatic cancer. In this study, we evaluated the relationship between the PD-L1 expression of surgical resected an...
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| Veröffentlicht in: | Journal of gastroenterology 2019-11, Vol.54 (11), p.1019-1028 |
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| creator | Matsumoto, Kazuyuki Ohara, Toshiaki Fujisawa, Masayoshi Takaki, Akinobu Takahara, Masahiro Tanaka, Noriyuki Kato, Hironari Horiguchi, Shigeru Yoshida, Ryuichi Umeda, Yuzo Fushimi, Soichiro Yagi, Takahito Matsukawa, Akihiro Okada, Hiroyuki |
| description | Background
Recently, therapeutic antibodies against programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) have shown promising clinical results for several solid tumors, including pancreatic cancer. In this study, we evaluated the relationship between the PD-L1 expression of surgical resected and fine-needle aspiration (FNA) specimens for patients with pancreatic cancer.
Methods
Of 121 patients who underwent endoscopic ultrasound-guided (EUS)–FNA before surgery for pancreatic cancer in an academic center, the 94 (78%) with adequate FNA specimens for a histological evaluation were retrospectively analyzed. All the patients had undergone upfront surgery without any chemotherapy or radiotherapy. We performed immunohistochemistry (IHC) staining to investigate the PD-L1 expression in both resected and FNA specimens. The positive-stained cells were counted, and their percentage was used for the investigation.
Results
Of the 94 patients, 16 (17%) and 11 (10%) were defined as positive on resected cancer specimens using cutoff points of 5% and 10% positively stained cancer cell counts, respectively. The concordance rates for the positive frequency of PD-L1 expression between resected and FNA specimens were 44% (7/16) and 55% (6/11) when the positivity was set to ≥ 5% and ≥ 10%, respectively. The concordance rates for the negative frequency of PD-L1 expression between two specimens were 97% (76/78) and 99% (82/83) when the positivity was set to ≥ 5% and ≥ 10%, respectively.
Conclusions
Approximately, half of the patients with PD-L1 expression positive and almost all the patients with PD-L1 expression negative could be diagnosed on FNA specimens. |
| doi_str_mv | 10.1007/s00535-019-01586-6 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2216769468</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714583177</galeid><sourcerecordid>A714583177</sourcerecordid><originalsourceid>FETCH-LOGICAL-c620t-8ea5afdf73a94bb862c3cb43b7650de2fae1b7b4d0f1f601b44a59e4a2d7b5833</originalsourceid><addsrcrecordid>eNp9kk1vFSEUhonR2Gv1D7gwJG7cTOWbmWVTP5Ob6KKuCTCHe2lmmBFm0vZH-J_l9lYbjTGEAOc878shHIReUnJGCdFvCyGSy4bQrk7ZqkY9Qhsqakh2jD1GG9IJ0VCqxQl6VsoVIZQT2T5FJ5wSziRrN-jH5R5whsEucUplH2fsYLkGSHipia_vmi3FcDNnKKUCeAq4rHkXvR2G26or4BfosU09DjFBkwD6AbAtc8x3lrjM4OMIqeAwZTzXIKSl4Ou47Osp-Qw15LGvW8jP0ZNghwIv7tdT9O3D-8uLT832y8fPF-fbxitGlqYFK23og-a2E861innuneBOK0l6YMECddqJngQaFKFOCCs7EJb12smW81P05ug75-n7CmUxYywehsEmmNZiGKNKq06otqKv_0KvpjWnWt2Bkl3LGdEP1M4OYGIK05KtP5iac01FvZPqA3X2D6qOHsbopwQh1vgfAnYU-DyVkiGYOcfR5ltDiTn0gDn2gKk9YO56wKgqenVf8epG6H9Lfn16BfgRKDWVdpAfnvQf258DF71W</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2215983207</pqid></control><display><type>article</type><title>The relationship between the PD-L1 expression of surgically resected and fine-needle aspiration specimens for patients with pancreatic cancer</title><source>SpringerLink Journals</source><creator>Matsumoto, Kazuyuki ; Ohara, Toshiaki ; Fujisawa, Masayoshi ; Takaki, Akinobu ; Takahara, Masahiro ; Tanaka, Noriyuki ; Kato, Hironari ; Horiguchi, Shigeru ; Yoshida, Ryuichi ; Umeda, Yuzo ; Fushimi, Soichiro ; Yagi, Takahito ; Matsukawa, Akihiro ; Okada, Hiroyuki</creator><creatorcontrib>Matsumoto, Kazuyuki ; Ohara, Toshiaki ; Fujisawa, Masayoshi ; Takaki, Akinobu ; Takahara, Masahiro ; Tanaka, Noriyuki ; Kato, Hironari ; Horiguchi, Shigeru ; Yoshida, Ryuichi ; Umeda, Yuzo ; Fushimi, Soichiro ; Yagi, Takahito ; Matsukawa, Akihiro ; Okada, Hiroyuki</creatorcontrib><description>Background
Recently, therapeutic antibodies against programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) have shown promising clinical results for several solid tumors, including pancreatic cancer. In this study, we evaluated the relationship between the PD-L1 expression of surgical resected and fine-needle aspiration (FNA) specimens for patients with pancreatic cancer.
Methods
Of 121 patients who underwent endoscopic ultrasound-guided (EUS)–FNA before surgery for pancreatic cancer in an academic center, the 94 (78%) with adequate FNA specimens for a histological evaluation were retrospectively analyzed. All the patients had undergone upfront surgery without any chemotherapy or radiotherapy. We performed immunohistochemistry (IHC) staining to investigate the PD-L1 expression in both resected and FNA specimens. The positive-stained cells were counted, and their percentage was used for the investigation.
Results
Of the 94 patients, 16 (17%) and 11 (10%) were defined as positive on resected cancer specimens using cutoff points of 5% and 10% positively stained cancer cell counts, respectively. The concordance rates for the positive frequency of PD-L1 expression between resected and FNA specimens were 44% (7/16) and 55% (6/11) when the positivity was set to ≥ 5% and ≥ 10%, respectively. The concordance rates for the negative frequency of PD-L1 expression between two specimens were 97% (76/78) and 99% (82/83) when the positivity was set to ≥ 5% and ≥ 10%, respectively.
Conclusions
Approximately, half of the patients with PD-L1 expression positive and almost all the patients with PD-L1 expression negative could be diagnosed on FNA specimens.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-019-01586-6</identifier><identifier>PMID: 31032528</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abdominal Surgery ; Analysis ; Antibodies ; Apoptosis ; Biliary Tract ; Biopsy ; Cancer ; Cancer patients ; Chemotherapy ; Colorectal Surgery ; Gastroenterology ; Health aspects ; Hepatology ; Immunohistochemistry ; Medical colleges ; Medicine ; Medicine & Public Health ; Original Article—Liver ; Pancreas ; Pancreatic cancer ; Patients ; PD-1 protein ; PD-L1 protein ; Radiation therapy ; Solid tumors ; Surgery ; Surgical Oncology ; Ultrasound ; Viral antibodies</subject><ispartof>Journal of gastroenterology, 2019-11, Vol.54 (11), p.1019-1028</ispartof><rights>Japanese Society of Gastroenterology 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Journal of Gastroenterology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c620t-8ea5afdf73a94bb862c3cb43b7650de2fae1b7b4d0f1f601b44a59e4a2d7b5833</citedby><cites>FETCH-LOGICAL-c620t-8ea5afdf73a94bb862c3cb43b7650de2fae1b7b4d0f1f601b44a59e4a2d7b5833</cites><orcidid>0000-0002-5102-7452</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-019-01586-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-019-01586-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31032528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsumoto, Kazuyuki</creatorcontrib><creatorcontrib>Ohara, Toshiaki</creatorcontrib><creatorcontrib>Fujisawa, Masayoshi</creatorcontrib><creatorcontrib>Takaki, Akinobu</creatorcontrib><creatorcontrib>Takahara, Masahiro</creatorcontrib><creatorcontrib>Tanaka, Noriyuki</creatorcontrib><creatorcontrib>Kato, Hironari</creatorcontrib><creatorcontrib>Horiguchi, Shigeru</creatorcontrib><creatorcontrib>Yoshida, Ryuichi</creatorcontrib><creatorcontrib>Umeda, Yuzo</creatorcontrib><creatorcontrib>Fushimi, Soichiro</creatorcontrib><creatorcontrib>Yagi, Takahito</creatorcontrib><creatorcontrib>Matsukawa, Akihiro</creatorcontrib><creatorcontrib>Okada, Hiroyuki</creatorcontrib><title>The relationship between the PD-L1 expression of surgically resected and fine-needle aspiration specimens for patients with pancreatic cancer</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
Recently, therapeutic antibodies against programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) have shown promising clinical results for several solid tumors, including pancreatic cancer. In this study, we evaluated the relationship between the PD-L1 expression of surgical resected and fine-needle aspiration (FNA) specimens for patients with pancreatic cancer.
Methods
Of 121 patients who underwent endoscopic ultrasound-guided (EUS)–FNA before surgery for pancreatic cancer in an academic center, the 94 (78%) with adequate FNA specimens for a histological evaluation were retrospectively analyzed. All the patients had undergone upfront surgery without any chemotherapy or radiotherapy. We performed immunohistochemistry (IHC) staining to investigate the PD-L1 expression in both resected and FNA specimens. The positive-stained cells were counted, and their percentage was used for the investigation.
Results
Of the 94 patients, 16 (17%) and 11 (10%) were defined as positive on resected cancer specimens using cutoff points of 5% and 10% positively stained cancer cell counts, respectively. The concordance rates for the positive frequency of PD-L1 expression between resected and FNA specimens were 44% (7/16) and 55% (6/11) when the positivity was set to ≥ 5% and ≥ 10%, respectively. The concordance rates for the negative frequency of PD-L1 expression between two specimens were 97% (76/78) and 99% (82/83) when the positivity was set to ≥ 5% and ≥ 10%, respectively.
Conclusions
Approximately, half of the patients with PD-L1 expression positive and almost all the patients with PD-L1 expression negative could be diagnosed on FNA specimens.</description><subject>Abdominal Surgery</subject><subject>Analysis</subject><subject>Antibodies</subject><subject>Apoptosis</subject><subject>Biliary Tract</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Chemotherapy</subject><subject>Colorectal Surgery</subject><subject>Gastroenterology</subject><subject>Health aspects</subject><subject>Hepatology</subject><subject>Immunohistochemistry</subject><subject>Medical colleges</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article—Liver</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Patients</subject><subject>PD-1 protein</subject><subject>PD-L1 protein</subject><subject>Radiation therapy</subject><subject>Solid tumors</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Ultrasound</subject><subject>Viral antibodies</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kk1vFSEUhonR2Gv1D7gwJG7cTOWbmWVTP5Ob6KKuCTCHe2lmmBFm0vZH-J_l9lYbjTGEAOc878shHIReUnJGCdFvCyGSy4bQrk7ZqkY9Qhsqakh2jD1GG9IJ0VCqxQl6VsoVIZQT2T5FJ5wSziRrN-jH5R5whsEucUplH2fsYLkGSHipia_vmi3FcDNnKKUCeAq4rHkXvR2G26or4BfosU09DjFBkwD6AbAtc8x3lrjM4OMIqeAwZTzXIKSl4Ou47Osp-Qw15LGvW8jP0ZNghwIv7tdT9O3D-8uLT832y8fPF-fbxitGlqYFK23og-a2E861innuneBOK0l6YMECddqJngQaFKFOCCs7EJb12smW81P05ug75-n7CmUxYywehsEmmNZiGKNKq06otqKv_0KvpjWnWt2Bkl3LGdEP1M4OYGIK05KtP5iac01FvZPqA3X2D6qOHsbopwQh1vgfAnYU-DyVkiGYOcfR5ltDiTn0gDn2gKk9YO56wKgqenVf8epG6H9Lfn16BfgRKDWVdpAfnvQf258DF71W</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Matsumoto, Kazuyuki</creator><creator>Ohara, Toshiaki</creator><creator>Fujisawa, Masayoshi</creator><creator>Takaki, Akinobu</creator><creator>Takahara, Masahiro</creator><creator>Tanaka, Noriyuki</creator><creator>Kato, Hironari</creator><creator>Horiguchi, Shigeru</creator><creator>Yoshida, Ryuichi</creator><creator>Umeda, Yuzo</creator><creator>Fushimi, Soichiro</creator><creator>Yagi, Takahito</creator><creator>Matsukawa, Akihiro</creator><creator>Okada, Hiroyuki</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5102-7452</orcidid></search><sort><creationdate>20191101</creationdate><title>The relationship between the PD-L1 expression of surgically resected and fine-needle aspiration specimens for patients with pancreatic cancer</title><author>Matsumoto, Kazuyuki ; Ohara, Toshiaki ; Fujisawa, Masayoshi ; Takaki, Akinobu ; Takahara, Masahiro ; Tanaka, Noriyuki ; Kato, Hironari ; Horiguchi, Shigeru ; Yoshida, Ryuichi ; Umeda, Yuzo ; Fushimi, Soichiro ; Yagi, Takahito ; Matsukawa, Akihiro ; Okada, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c620t-8ea5afdf73a94bb862c3cb43b7650de2fae1b7b4d0f1f601b44a59e4a2d7b5833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdominal Surgery</topic><topic>Analysis</topic><topic>Antibodies</topic><topic>Apoptosis</topic><topic>Biliary Tract</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Chemotherapy</topic><topic>Colorectal Surgery</topic><topic>Gastroenterology</topic><topic>Health aspects</topic><topic>Hepatology</topic><topic>Immunohistochemistry</topic><topic>Medical colleges</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article—Liver</topic><topic>Pancreas</topic><topic>Pancreatic cancer</topic><topic>Patients</topic><topic>PD-1 protein</topic><topic>PD-L1 protein</topic><topic>Radiation therapy</topic><topic>Solid tumors</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Ultrasound</topic><topic>Viral antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsumoto, Kazuyuki</creatorcontrib><creatorcontrib>Ohara, Toshiaki</creatorcontrib><creatorcontrib>Fujisawa, Masayoshi</creatorcontrib><creatorcontrib>Takaki, Akinobu</creatorcontrib><creatorcontrib>Takahara, Masahiro</creatorcontrib><creatorcontrib>Tanaka, Noriyuki</creatorcontrib><creatorcontrib>Kato, Hironari</creatorcontrib><creatorcontrib>Horiguchi, Shigeru</creatorcontrib><creatorcontrib>Yoshida, Ryuichi</creatorcontrib><creatorcontrib>Umeda, Yuzo</creatorcontrib><creatorcontrib>Fushimi, Soichiro</creatorcontrib><creatorcontrib>Yagi, Takahito</creatorcontrib><creatorcontrib>Matsukawa, Akihiro</creatorcontrib><creatorcontrib>Okada, Hiroyuki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsumoto, Kazuyuki</au><au>Ohara, Toshiaki</au><au>Fujisawa, Masayoshi</au><au>Takaki, Akinobu</au><au>Takahara, Masahiro</au><au>Tanaka, Noriyuki</au><au>Kato, Hironari</au><au>Horiguchi, Shigeru</au><au>Yoshida, Ryuichi</au><au>Umeda, Yuzo</au><au>Fushimi, Soichiro</au><au>Yagi, Takahito</au><au>Matsukawa, Akihiro</au><au>Okada, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between the PD-L1 expression of surgically resected and fine-needle aspiration specimens for patients with pancreatic cancer</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>54</volume><issue>11</issue><spage>1019</spage><epage>1028</epage><pages>1019-1028</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background
Recently, therapeutic antibodies against programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) have shown promising clinical results for several solid tumors, including pancreatic cancer. In this study, we evaluated the relationship between the PD-L1 expression of surgical resected and fine-needle aspiration (FNA) specimens for patients with pancreatic cancer.
Methods
Of 121 patients who underwent endoscopic ultrasound-guided (EUS)–FNA before surgery for pancreatic cancer in an academic center, the 94 (78%) with adequate FNA specimens for a histological evaluation were retrospectively analyzed. All the patients had undergone upfront surgery without any chemotherapy or radiotherapy. We performed immunohistochemistry (IHC) staining to investigate the PD-L1 expression in both resected and FNA specimens. The positive-stained cells were counted, and their percentage was used for the investigation.
Results
Of the 94 patients, 16 (17%) and 11 (10%) were defined as positive on resected cancer specimens using cutoff points of 5% and 10% positively stained cancer cell counts, respectively. The concordance rates for the positive frequency of PD-L1 expression between resected and FNA specimens were 44% (7/16) and 55% (6/11) when the positivity was set to ≥ 5% and ≥ 10%, respectively. The concordance rates for the negative frequency of PD-L1 expression between two specimens were 97% (76/78) and 99% (82/83) when the positivity was set to ≥ 5% and ≥ 10%, respectively.
Conclusions
Approximately, half of the patients with PD-L1 expression positive and almost all the patients with PD-L1 expression negative could be diagnosed on FNA specimens.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>31032528</pmid><doi>10.1007/s00535-019-01586-6</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-5102-7452</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of gastroenterology, 2019-11, Vol.54 (11), p.1019-1028 |
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| subjects | Abdominal Surgery Analysis Antibodies Apoptosis Biliary Tract Biopsy Cancer Cancer patients Chemotherapy Colorectal Surgery Gastroenterology Health aspects Hepatology Immunohistochemistry Medical colleges Medicine Medicine & Public Health Original Article—Liver Pancreas Pancreatic cancer Patients PD-1 protein PD-L1 protein Radiation therapy Solid tumors Surgery Surgical Oncology Ultrasound Viral antibodies |
| title | The relationship between the PD-L1 expression of surgically resected and fine-needle aspiration specimens for patients with pancreatic cancer |
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