Combination treatment of podophyllotoxin and rutin promotes mouse Lgr5+ ve intestinal stem cells survival against lethal radiation injury through Wnt signaling

It has been well established that radiation-induced gastrointestinal injury is manifested through loss of intestinal crypt stem cells and disruption of the mucosal layers, resulting in diarrhoea, weight loss, electrolyte imbalance, infection and mortality. Podophyllotoxin and rutin in combination (G...

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Veröffentlicht in:	Apoptosis (London) 2019-04, Vol.24 (3-4), p.326-340
Hauptverfasser:	Kalita, Bhargab, Ranjan, Rajiv, Gupta, Manju Lata
Format:	Artikel
Sprache:	eng
Schlagworte:	Amifostine Animals Antioxidants Antiviral drugs Apoptosis beta Catenin - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell Biology Deoxyribonucleic acid Diarrhea DNA DNA damage DNA Damage - drug effects Drug Therapy, Combination - methods Electrolytic cells Immune system Infiltration Inflammation Inflammation - metabolism Inflammatory response Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestine Intestines - drug effects Male Metastases Mice Mice, Inbred C57BL Mucosa Nuclear transport Oncology Podophyllotoxin Podophyllotoxin - physiology Radiation damage Radiation effects Radiation injuries Radiation Injuries - drug therapy Radiation Injuries - metabolism Radiation-Protective Agents - pharmacology Receptors, G-Protein-Coupled - metabolism Regeneration Rutin Rutin - physiology Signaling Stem cell transplantation Stem cells Stem Cells - drug effects Stem Cells - metabolism Structure-function relationships Survival Translocation Up-Regulation - drug effects Virology Weight loss Wnt protein Wnt Signaling Pathway - drug effects β-Catenin
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