Targeting Plant ssDNA Viruses with Engineered Miniature CRISPR-Cas14a

CRISPR-Cas14a is a highly compact protein with great potential to be used as a guided genome editing tool for single-stranded (ss) DNA cleavage. Recently isolated from noncultured archaea, its unrestricted and sequence-independent cleavage makes it an ideal tool for engineering resistance against ec...

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Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2019-08, Vol.37 (8), p.800-804
Hauptverfasser:	Khan, Muhammad Zuhaib, Haider, Sibtain, Mansoor, Shahid, Amin, Imran
Format:	Artikel
Sprache:	eng
Schlagworte:	Advantages Archaea Cleavage CRISPR CRISPR-Cas13a CRISPR-Cas14a CRISPR-Cas9 Deoxyribonucleic acid DNA Economic importance Genome editing Genomes Infections Mutation Nucleotide sequence Plant viruses Proteins Single-stranded DNA ssDNA cleavage ssDNA viruses Viral infections Viruses
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