Subphthalocyanine as a fluorescence imaging agent for breast tumor
•Subphthalocyanine is a fluorescent probe. In vivo study was carried out in nude mice bearing mammary cancer.•This fluorescent probe might be used in the imaging of mammary cancer.•Subphthalocyanine could be developed as dual agent.•Its dual functional is optic imaging and photodynamic therapeutic a...
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| Veröffentlicht in: | Photodiagnosis and photodynamic therapy 2019-06, Vol.26, p.361-365 |
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| container_title | Photodiagnosis and photodynamic therapy |
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| creator | Yurt, Fatma Ince, Mine Er, Ozge Melis Soylu, Hale Ocakoglu, Kasim Yilmaz, Osman |
| description | •Subphthalocyanine is a fluorescent probe. In vivo study was carried out in nude mice bearing mammary cancer.•This fluorescent probe might be used in the imaging of mammary cancer.•Subphthalocyanine could be developed as dual agent.•Its dual functional is optic imaging and photodynamic therapeutic agent for the diagnosis and treatment
Tri-tert-butyl-carboxyl subphthalocyanine (SubPc) was synthesized and evaluated as a fluorescence agent. Fluorescence imaging for breast tumor in vivo was performed using nude mice as models. Results indicate high uptake in tumor at 20 h. Tumor-non tumor ratio was determined as 2.25. The imaging results demonstrate the potential of this fluorescence-imaging agent in the diagnosis of breast tumor. In the future, subphthalocyanine is also developing as a dual functional, which is fluorescence imaging and as a photodynamic therapeutic agent for the treatment and diagnosis of cancer. |
| doi_str_mv | 10.1016/j.pdpdt.2019.04.022 |
| format | Article |
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Tri-tert-butyl-carboxyl subphthalocyanine (SubPc) was synthesized and evaluated as a fluorescence agent. Fluorescence imaging for breast tumor in vivo was performed using nude mice as models. Results indicate high uptake in tumor at 20 h. Tumor-non tumor ratio was determined as 2.25. The imaging results demonstrate the potential of this fluorescence-imaging agent in the diagnosis of breast tumor. In the future, subphthalocyanine is also developing as a dual functional, which is fluorescence imaging and as a photodynamic therapeutic agent for the treatment and diagnosis of cancer.</description><identifier>ISSN: 1572-1000</identifier><identifier>EISSN: 1873-1597</identifier><identifier>DOI: 10.1016/j.pdpdt.2019.04.022</identifier><identifier>PMID: 31026614</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Female ; Fluorescence imaging ; Indoles - chemical synthesis ; Indoles - pharmacology ; Mammary Neoplasms, Experimental - diagnostic imaging ; Mammary tumor ; Mice ; Mice, Nude ; Nude mice ; Optical Imaging - methods ; Photosensitizing Agents - chemical synthesis ; Photosensitizing Agents - pharmacology ; Subphthalocyanine</subject><ispartof>Photodiagnosis and photodynamic therapy, 2019-06, Vol.26, p.361-365</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-d92a1fd762403eee4c65b98eb694e29e4336995f8a3a2d1bd8f04fad5cc84ec83</citedby><cites>FETCH-LOGICAL-c359t-d92a1fd762403eee4c65b98eb694e29e4336995f8a3a2d1bd8f04fad5cc84ec83</cites><orcidid>0000-0001-8253-8346</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pdpdt.2019.04.022$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31026614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yurt, Fatma</creatorcontrib><creatorcontrib>Ince, Mine</creatorcontrib><creatorcontrib>Er, Ozge</creatorcontrib><creatorcontrib>Melis Soylu, Hale</creatorcontrib><creatorcontrib>Ocakoglu, Kasim</creatorcontrib><creatorcontrib>Yilmaz, Osman</creatorcontrib><title>Subphthalocyanine as a fluorescence imaging agent for breast tumor</title><title>Photodiagnosis and photodynamic therapy</title><addtitle>Photodiagnosis Photodyn Ther</addtitle><description>•Subphthalocyanine is a fluorescent probe. In vivo study was carried out in nude mice bearing mammary cancer.•This fluorescent probe might be used in the imaging of mammary cancer.•Subphthalocyanine could be developed as dual agent.•Its dual functional is optic imaging and photodynamic therapeutic agent for the diagnosis and treatment
Tri-tert-butyl-carboxyl subphthalocyanine (SubPc) was synthesized and evaluated as a fluorescence agent. Fluorescence imaging for breast tumor in vivo was performed using nude mice as models. Results indicate high uptake in tumor at 20 h. Tumor-non tumor ratio was determined as 2.25. The imaging results demonstrate the potential of this fluorescence-imaging agent in the diagnosis of breast tumor. In the future, subphthalocyanine is also developing as a dual functional, which is fluorescence imaging and as a photodynamic therapeutic agent for the treatment and diagnosis of cancer.</description><subject>Animals</subject><subject>Female</subject><subject>Fluorescence imaging</subject><subject>Indoles - chemical synthesis</subject><subject>Indoles - pharmacology</subject><subject>Mammary Neoplasms, Experimental - diagnostic imaging</subject><subject>Mammary tumor</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Nude mice</subject><subject>Optical Imaging - methods</subject><subject>Photosensitizing Agents - chemical synthesis</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Subphthalocyanine</subject><issn>1572-1000</issn><issn>1873-1597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0EoqXwC5BQjlwS_IoTHzhAxUuqxAE4W469aV2lSbATpP57XFo4cto9zOzsfAhdEpwRTMTNOuttb4eMYiIzzDNM6RGakrJgKcllcRz3vKApwRhP0FkIa4wZl5ifogkjmApB-BTdv41VvxpWuunMVreuhUSHRCd1M3YegoHWQOI2eunaZaKX0A5J3fmk8qDDkAzjpvPn6KTWTYCLw5yhj8eH9_lzunh9epnfLVLDcjmkVlJNalsIyjEDAG5EXskSKiE5UAmcMSFlXpeaaWpJZcsa81rb3JiSgynZDF3v7_a--xwhDGrj4oNNo1voxqAoJYLKnDIRpWwvNb4LwUOteh9L-K0iWO3gqbX6gad28BTmKsKLrqtDwFhtwP55fmlFwe1eALHmlwOvgnE7QtZ5MIOynfs34BvlLoGu</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Yurt, Fatma</creator><creator>Ince, Mine</creator><creator>Er, Ozge</creator><creator>Melis Soylu, Hale</creator><creator>Ocakoglu, Kasim</creator><creator>Yilmaz, Osman</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8253-8346</orcidid></search><sort><creationdate>201906</creationdate><title>Subphthalocyanine as a fluorescence imaging agent for breast tumor</title><author>Yurt, Fatma ; Ince, Mine ; Er, Ozge ; Melis Soylu, Hale ; Ocakoglu, Kasim ; Yilmaz, Osman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-d92a1fd762403eee4c65b98eb694e29e4336995f8a3a2d1bd8f04fad5cc84ec83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Female</topic><topic>Fluorescence imaging</topic><topic>Indoles - chemical synthesis</topic><topic>Indoles - pharmacology</topic><topic>Mammary Neoplasms, Experimental - diagnostic imaging</topic><topic>Mammary tumor</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Nude mice</topic><topic>Optical Imaging - methods</topic><topic>Photosensitizing Agents - chemical synthesis</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Subphthalocyanine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yurt, Fatma</creatorcontrib><creatorcontrib>Ince, Mine</creatorcontrib><creatorcontrib>Er, Ozge</creatorcontrib><creatorcontrib>Melis Soylu, Hale</creatorcontrib><creatorcontrib>Ocakoglu, Kasim</creatorcontrib><creatorcontrib>Yilmaz, Osman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photodiagnosis and photodynamic therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yurt, Fatma</au><au>Ince, Mine</au><au>Er, Ozge</au><au>Melis Soylu, Hale</au><au>Ocakoglu, Kasim</au><au>Yilmaz, Osman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subphthalocyanine as a fluorescence imaging agent for breast tumor</atitle><jtitle>Photodiagnosis and photodynamic therapy</jtitle><addtitle>Photodiagnosis Photodyn Ther</addtitle><date>2019-06</date><risdate>2019</risdate><volume>26</volume><spage>361</spage><epage>365</epage><pages>361-365</pages><issn>1572-1000</issn><eissn>1873-1597</eissn><abstract>•Subphthalocyanine is a fluorescent probe. In vivo study was carried out in nude mice bearing mammary cancer.•This fluorescent probe might be used in the imaging of mammary cancer.•Subphthalocyanine could be developed as dual agent.•Its dual functional is optic imaging and photodynamic therapeutic agent for the diagnosis and treatment
Tri-tert-butyl-carboxyl subphthalocyanine (SubPc) was synthesized and evaluated as a fluorescence agent. Fluorescence imaging for breast tumor in vivo was performed using nude mice as models. Results indicate high uptake in tumor at 20 h. Tumor-non tumor ratio was determined as 2.25. The imaging results demonstrate the potential of this fluorescence-imaging agent in the diagnosis of breast tumor. In the future, subphthalocyanine is also developing as a dual functional, which is fluorescence imaging and as a photodynamic therapeutic agent for the treatment and diagnosis of cancer.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31026614</pmid><doi>10.1016/j.pdpdt.2019.04.022</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-8253-8346</orcidid></addata></record> |
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| ispartof | Photodiagnosis and photodynamic therapy, 2019-06, Vol.26, p.361-365 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Female Fluorescence imaging Indoles - chemical synthesis Indoles - pharmacology Mammary Neoplasms, Experimental - diagnostic imaging Mammary tumor Mice Mice, Nude Nude mice Optical Imaging - methods Photosensitizing Agents - chemical synthesis Photosensitizing Agents - pharmacology Subphthalocyanine |
| title | Subphthalocyanine as a fluorescence imaging agent for breast tumor |
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