Single‐Needle Intensive Granulocyte and Monocyte Adsorptive Apheresis Is Suitable for Elderly Patients With Active Ulcerative Colitis Taking no Corticosteroids or Biologics
Twice‐weekly intensive granulocyte/monocyte adsorptive apheresis is effective and safe for ulcerative colitis, but maintaining two blood access routes is problematic. We previously reported that intensive granulocyte/monocyte adsorptive apheresis using a single needle in ulcerative colitis is effect...
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| Veröffentlicht in: | Therapeutic apheresis and dialysis 2019-06, Vol.23 (3), p.224-232 |
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| creator | Fukuchi, Takumi Koga, Hideaki Kaichi, Shinji Ishikawa, Akira Horita, Takahisa Araki, Ryota Yokota, Atsushi Namba, Yukiomi Kyo, Masahiro Eguchi, Takaaki Shimazu, Keiji |
| description | Twice‐weekly intensive granulocyte/monocyte adsorptive apheresis is effective and safe for ulcerative colitis, but maintaining two blood access routes is problematic. We previously reported that intensive granulocyte/monocyte adsorptive apheresis using a single needle in ulcerative colitis is effective and safe. We hypothesized that the efficacy and safety of single‐needle intensive granulocyte/monocyte adsorptive apheresis for ulcerative colitis would especially benefit the elderly. We enrolled 17 elderly ulcerative colitis patients to receive single‐needle intensive granulocyte/monocyte adsorptive apheresis, 27 elderly ulcerative colitis patients to receive double‐needle intensive granulocyte/monocyte adsorptive apheresis, and 52 nonelderly ulcerative colitis patients to receive single‐needle intensive granulocyte/monocyte adsorptive apheresis. Remission and mucosal healing rates after treatment did not differ significantly between elderly ulcerative colitis patients receiving single‐needle apheresis and the other two groups. In addition, no serious adverse effects, including blood clots, were observed in single‐needle intensive granulocyte/monocyte adsorptive apheresis patients. Single‐needle intensive granulocyte/monocyte adsorptive apheresis might be a novel alternative therapeutic option for elderly ulcerative colitis patients before considering corticosteroids. |
| doi_str_mv | 10.1111/1744-9987.12819 |
| format | Article |
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We previously reported that intensive granulocyte/monocyte adsorptive apheresis using a single needle in ulcerative colitis is effective and safe. We hypothesized that the efficacy and safety of single‐needle intensive granulocyte/monocyte adsorptive apheresis for ulcerative colitis would especially benefit the elderly. We enrolled 17 elderly ulcerative colitis patients to receive single‐needle intensive granulocyte/monocyte adsorptive apheresis, 27 elderly ulcerative colitis patients to receive double‐needle intensive granulocyte/monocyte adsorptive apheresis, and 52 nonelderly ulcerative colitis patients to receive single‐needle intensive granulocyte/monocyte adsorptive apheresis. Remission and mucosal healing rates after treatment did not differ significantly between elderly ulcerative colitis patients receiving single‐needle apheresis and the other two groups. In addition, no serious adverse effects, including blood clots, were observed in single‐needle intensive granulocyte/monocyte adsorptive apheresis patients. Single‐needle intensive granulocyte/monocyte adsorptive apheresis might be a novel alternative therapeutic option for elderly ulcerative colitis patients before considering corticosteroids.</description><identifier>ISSN: 1744-9979</identifier><identifier>EISSN: 1744-9987</identifier><identifier>DOI: 10.1111/1744-9987.12819</identifier><identifier>PMID: 31025824</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Adrenal Cortex Hormones ; Adsorption ; Aged ; Aged, 80 and over ; Biological Products ; Cohort Studies ; Colitis, Ulcerative - diagnosis ; Colitis, Ulcerative - therapy ; Corticosteroid naïve ; Elderly ; Female ; Geriatric Assessment ; Granulocytes - cytology ; Humans ; Intensive granulocyte and monocyte adsorptive apheresis ; Japan ; Leukapheresis - methods ; Male ; Middle Aged ; Monocytes - cytology ; Needles ; Patient Safety ; Severity of Illness Index ; Single‐needle induction ; Treatment Outcome ; Ulcerative colitis</subject><ispartof>Therapeutic apheresis and dialysis, 2019-06, Vol.23 (3), p.224-232</ispartof><rights>2019 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy</rights><rights>2019 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3679-ac889a6118a0c14df5410a7a0673480b8f3d3de2aa5e2498da5ef80de9bfb79d3</citedby><cites>FETCH-LOGICAL-c3679-ac889a6118a0c14df5410a7a0673480b8f3d3de2aa5e2498da5ef80de9bfb79d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1744-9987.12819$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1744-9987.12819$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31025824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukuchi, Takumi</creatorcontrib><creatorcontrib>Koga, Hideaki</creatorcontrib><creatorcontrib>Kaichi, Shinji</creatorcontrib><creatorcontrib>Ishikawa, Akira</creatorcontrib><creatorcontrib>Horita, Takahisa</creatorcontrib><creatorcontrib>Araki, Ryota</creatorcontrib><creatorcontrib>Yokota, Atsushi</creatorcontrib><creatorcontrib>Namba, Yukiomi</creatorcontrib><creatorcontrib>Kyo, Masahiro</creatorcontrib><creatorcontrib>Eguchi, Takaaki</creatorcontrib><creatorcontrib>Shimazu, Keiji</creatorcontrib><title>Single‐Needle Intensive Granulocyte and Monocyte Adsorptive Apheresis Is Suitable for Elderly Patients With Active Ulcerative Colitis Taking no Corticosteroids or Biologics</title><title>Therapeutic apheresis and dialysis</title><addtitle>Ther Apher Dial</addtitle><description>Twice‐weekly intensive granulocyte/monocyte adsorptive apheresis is effective and safe for ulcerative colitis, but maintaining two blood access routes is problematic. We previously reported that intensive granulocyte/monocyte adsorptive apheresis using a single needle in ulcerative colitis is effective and safe. We hypothesized that the efficacy and safety of single‐needle intensive granulocyte/monocyte adsorptive apheresis for ulcerative colitis would especially benefit the elderly. We enrolled 17 elderly ulcerative colitis patients to receive single‐needle intensive granulocyte/monocyte adsorptive apheresis, 27 elderly ulcerative colitis patients to receive double‐needle intensive granulocyte/monocyte adsorptive apheresis, and 52 nonelderly ulcerative colitis patients to receive single‐needle intensive granulocyte/monocyte adsorptive apheresis. Remission and mucosal healing rates after treatment did not differ significantly between elderly ulcerative colitis patients receiving single‐needle apheresis and the other two groups. In addition, no serious adverse effects, including blood clots, were observed in single‐needle intensive granulocyte/monocyte adsorptive apheresis patients. Single‐needle intensive granulocyte/monocyte adsorptive apheresis might be a novel alternative therapeutic option for elderly ulcerative colitis patients before considering corticosteroids.</description><subject>Adrenal Cortex Hormones</subject><subject>Adsorption</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological Products</subject><subject>Cohort Studies</subject><subject>Colitis, Ulcerative - diagnosis</subject><subject>Colitis, Ulcerative - therapy</subject><subject>Corticosteroid naïve</subject><subject>Elderly</subject><subject>Female</subject><subject>Geriatric Assessment</subject><subject>Granulocytes - cytology</subject><subject>Humans</subject><subject>Intensive granulocyte and monocyte adsorptive apheresis</subject><subject>Japan</subject><subject>Leukapheresis - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monocytes - cytology</subject><subject>Needles</subject><subject>Patient Safety</subject><subject>Severity of Illness Index</subject><subject>Single‐needle induction</subject><subject>Treatment Outcome</subject><subject>Ulcerative colitis</subject><issn>1744-9979</issn><issn>1744-9987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9uEzEQh1cIREvhzA35yCWt7fVm7eMS9U-kApWaiqPltWdbg2MH2wvKrY_Ak_BQPAlOtuSKLzMeffNppF9VvSX4lJR3RlrGZkLw9pRQTsSz6vgweX7oW3FUvUrpK8aUsrp-WR3VBNOGU3Zc_b61_t7Bn8dfnwCMA7T0GXyyPwBdRuVHF_Q2A1LeoI_BT5_OpBA3ecd0mweIkGxCy4RuR5tVXxxDiOjcGYhui25UtuBzQl9sfkCd3q_dOQ1R7dtFcDaX_ZX6Vi5BPpRJzFaHlCEGaxIqsg82uHBvdXpdvRiUS_DmqZ5Udxfnq8XV7Prz5XLRXc90PW_FTGnOhZoTwhXWhJmhYQSrVuF5WzOOez7UpjZAlWqAMsFNqQPHBkQ_9K0w9Un1fvJuYvg-QspybZMG55SHMCZJKZlTQRvMCno2oTqGlCIMchPtWsWtJFjuQpK7GOQuErkPqWy8e5KP_RrMgf-XSgGaCfhpHWz_55Or7mYS_wUTjaEY</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Fukuchi, Takumi</creator><creator>Koga, Hideaki</creator><creator>Kaichi, Shinji</creator><creator>Ishikawa, Akira</creator><creator>Horita, Takahisa</creator><creator>Araki, Ryota</creator><creator>Yokota, Atsushi</creator><creator>Namba, Yukiomi</creator><creator>Kyo, Masahiro</creator><creator>Eguchi, Takaaki</creator><creator>Shimazu, Keiji</creator><general>John Wiley & Sons Australia, Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201906</creationdate><title>Single‐Needle Intensive Granulocyte and Monocyte Adsorptive Apheresis Is Suitable for Elderly Patients With Active Ulcerative Colitis Taking no Corticosteroids or Biologics</title><author>Fukuchi, Takumi ; Koga, Hideaki ; Kaichi, Shinji ; Ishikawa, Akira ; Horita, Takahisa ; Araki, Ryota ; Yokota, Atsushi ; Namba, Yukiomi ; Kyo, Masahiro ; Eguchi, Takaaki ; Shimazu, Keiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3679-ac889a6118a0c14df5410a7a0673480b8f3d3de2aa5e2498da5ef80de9bfb79d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adrenal Cortex Hormones</topic><topic>Adsorption</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological Products</topic><topic>Cohort Studies</topic><topic>Colitis, Ulcerative - diagnosis</topic><topic>Colitis, Ulcerative - therapy</topic><topic>Corticosteroid naïve</topic><topic>Elderly</topic><topic>Female</topic><topic>Geriatric Assessment</topic><topic>Granulocytes - cytology</topic><topic>Humans</topic><topic>Intensive granulocyte and monocyte adsorptive apheresis</topic><topic>Japan</topic><topic>Leukapheresis - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monocytes - cytology</topic><topic>Needles</topic><topic>Patient Safety</topic><topic>Severity of Illness Index</topic><topic>Single‐needle induction</topic><topic>Treatment Outcome</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukuchi, Takumi</creatorcontrib><creatorcontrib>Koga, Hideaki</creatorcontrib><creatorcontrib>Kaichi, Shinji</creatorcontrib><creatorcontrib>Ishikawa, Akira</creatorcontrib><creatorcontrib>Horita, Takahisa</creatorcontrib><creatorcontrib>Araki, Ryota</creatorcontrib><creatorcontrib>Yokota, Atsushi</creatorcontrib><creatorcontrib>Namba, Yukiomi</creatorcontrib><creatorcontrib>Kyo, Masahiro</creatorcontrib><creatorcontrib>Eguchi, Takaaki</creatorcontrib><creatorcontrib>Shimazu, Keiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Therapeutic apheresis and dialysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukuchi, Takumi</au><au>Koga, Hideaki</au><au>Kaichi, Shinji</au><au>Ishikawa, Akira</au><au>Horita, Takahisa</au><au>Araki, Ryota</au><au>Yokota, Atsushi</au><au>Namba, Yukiomi</au><au>Kyo, Masahiro</au><au>Eguchi, Takaaki</au><au>Shimazu, Keiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single‐Needle Intensive Granulocyte and Monocyte Adsorptive Apheresis Is Suitable for Elderly Patients With Active Ulcerative Colitis Taking no Corticosteroids or Biologics</atitle><jtitle>Therapeutic apheresis and dialysis</jtitle><addtitle>Ther Apher Dial</addtitle><date>2019-06</date><risdate>2019</risdate><volume>23</volume><issue>3</issue><spage>224</spage><epage>232</epage><pages>224-232</pages><issn>1744-9979</issn><eissn>1744-9987</eissn><abstract>Twice‐weekly intensive granulocyte/monocyte adsorptive apheresis is effective and safe for ulcerative colitis, but maintaining two blood access routes is problematic. We previously reported that intensive granulocyte/monocyte adsorptive apheresis using a single needle in ulcerative colitis is effective and safe. We hypothesized that the efficacy and safety of single‐needle intensive granulocyte/monocyte adsorptive apheresis for ulcerative colitis would especially benefit the elderly. We enrolled 17 elderly ulcerative colitis patients to receive single‐needle intensive granulocyte/monocyte adsorptive apheresis, 27 elderly ulcerative colitis patients to receive double‐needle intensive granulocyte/monocyte adsorptive apheresis, and 52 nonelderly ulcerative colitis patients to receive single‐needle intensive granulocyte/monocyte adsorptive apheresis. Remission and mucosal healing rates after treatment did not differ significantly between elderly ulcerative colitis patients receiving single‐needle apheresis and the other two groups. In addition, no serious adverse effects, including blood clots, were observed in single‐needle intensive granulocyte/monocyte adsorptive apheresis patients. Single‐needle intensive granulocyte/monocyte adsorptive apheresis might be a novel alternative therapeutic option for elderly ulcerative colitis patients before considering corticosteroids.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>31025824</pmid><doi>10.1111/1744-9987.12819</doi><tpages>9</tpages></addata></record> |
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| ispartof | Therapeutic apheresis and dialysis, 2019-06, Vol.23 (3), p.224-232 |
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| subjects | Adrenal Cortex Hormones Adsorption Aged Aged, 80 and over Biological Products Cohort Studies Colitis, Ulcerative - diagnosis Colitis, Ulcerative - therapy Corticosteroid naïve Elderly Female Geriatric Assessment Granulocytes - cytology Humans Intensive granulocyte and monocyte adsorptive apheresis Japan Leukapheresis - methods Male Middle Aged Monocytes - cytology Needles Patient Safety Severity of Illness Index Single‐needle induction Treatment Outcome Ulcerative colitis |
| title | Single‐Needle Intensive Granulocyte and Monocyte Adsorptive Apheresis Is Suitable for Elderly Patients With Active Ulcerative Colitis Taking no Corticosteroids or Biologics |
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