Oxygen Cost During Mobility Tasks and Its Relationship to Fatigue in Progressive Multiple Sclerosis

To compare the oxygen costs of mobility tasks between individuals with progressive multiple sclerosis (MS) using walking aids and matched controls and to determine whether oxygen cost predicted fatigue. Cross-sectional descriptive. A rehabilitation research laboratory. A total of 14 adults with prog...

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Veröffentlicht in:	Archives of physical medicine and rehabilitation 2019-11, Vol.100 (11), p.2079-2088
Hauptverfasser:	Devasahayam, Augustine J., Kelly, Liam P., Wallack, Elizabeth M., Ploughman, Michelle
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Sprache:	eng
Schlagworte:	Activities of daily living Cardiovascular deconditioning Cross-Sectional Studies Fatigue Fatigue - physiopathology Female Humans Male Multiple sclerosis Multiple Sclerosis - physiopathology Multiple Sclerosis - rehabilitation Orthopedic Equipment Oxygen consumption Oxygen Consumption - physiology Physical Exertion - physiology Physical Therapy Modalities Rehabilitation Walking - physiology
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container_title	Archives of physical medicine and rehabilitation
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creator	Devasahayam, Augustine J. Kelly, Liam P. Wallack, Elizabeth M. Ploughman, Michelle
description	To compare the oxygen costs of mobility tasks between individuals with progressive multiple sclerosis (MS) using walking aids and matched controls and to determine whether oxygen cost predicted fatigue. Cross-sectional descriptive. A rehabilitation research laboratory. A total of 14 adults with progressive MS (mean age ± SD [y], 54.07±8.46) using walking aids and 8 age- and sex-matched controls without MS (N=22). Participants performed 5 mobility tasks (rolling in bed, lying to sitting, sitting to standing, walking, climbing steps) wearing a portable metabolic cart. Oxygen consumption (V˙o2) during mobility tasks, maximal V˙o2 during graded maximal exercise test, perceived exertion, and task-induced fatigue were measured on a visual analog scale before and after mobility tasks. People with progressive MS had significantly higher oxygen cost in all tasks compared to controls (P
doi_str_mv	10.1016/j.apmr.2019.03.017
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Cross-sectional descriptive. A rehabilitation research laboratory. A total of 14 adults with progressive MS (mean age ± SD [y], 54.07±8.46) using walking aids and 8 age- and sex-matched controls without MS (N=22). Participants performed 5 mobility tasks (rolling in bed, lying to sitting, sitting to standing, walking, climbing steps) wearing a portable metabolic cart. Oxygen consumption (V˙o2) during mobility tasks, maximal V˙o2 during graded maximal exercise test, perceived exertion, and task-induced fatigue were measured on a visual analog scale before and after mobility tasks. People with progressive MS had significantly higher oxygen cost in all tasks compared to controls (P<.05): climbing steps (3.60 times more in MS), rolling in bed (3.53), walking (3.10), lying to sitting (2.50), and sitting to standing (1.82). There was a strong, positive correlation between task-induced fatigue and oxygen cost of walking, (ρ [13]=0.626, P=.022). People with progressive MS used 2.81 times more energy on average for mobility tasks compared to controls. People with progressive MS experienced accumulation of oxygen cost, fatigue, and exertion when repeating tasks and higher oxygen cost during walking was related to greater perception of fatigue. Our findings suggest that rehabilitation interventions that increase endurance during functional tasks could help reduce fatigue in people with progressive MS who use walking aids. •People with progressive multiple sclerosis (MS) consume 2.81 times more energy during mobility tasks.•Accumulation of oxygen cost and fatigue suggest deconditioning in persons with MS.•Oxygen cost of walking is a significant predictor of fatigue in progressive MS.</description><identifier>ISSN: 0003-9993</identifier><identifier>EISSN: 1532-821X</identifier><identifier>DOI: 10.1016/j.apmr.2019.03.017</identifier><identifier>PMID: 31026463</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Activities of daily living ; Cardiovascular deconditioning ; Cross-Sectional Studies ; Fatigue ; Fatigue - physiopathology ; Female ; Humans ; Male ; Multiple sclerosis ; Multiple Sclerosis - physiopathology ; Multiple Sclerosis - rehabilitation ; Orthopedic Equipment ; Oxygen consumption ; Oxygen Consumption - physiology ; Physical Exertion - physiology ; Physical Therapy Modalities ; Rehabilitation ; Walking - physiology</subject><ispartof>Archives of physical medicine and rehabilitation, 2019-11, Vol.100 (11), p.2079-2088</ispartof><rights>2019 American Congress of Rehabilitation Medicine</rights><rights>Copyright © 2019 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-99bd6df081ccfc4b4d93f1a9a0f53c71d901b467cbf2be934e99c78d7cdf3c63</citedby><cites>FETCH-LOGICAL-c356t-99bd6df081ccfc4b4d93f1a9a0f53c71d901b467cbf2be934e99c78d7cdf3c63</cites><orcidid>0000-0001-6618-1543 ; 0000-0002-4594-0077</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.apmr.2019.03.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31026463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Devasahayam, Augustine J.</creatorcontrib><creatorcontrib>Kelly, Liam P.</creatorcontrib><creatorcontrib>Wallack, Elizabeth M.</creatorcontrib><creatorcontrib>Ploughman, Michelle</creatorcontrib><title>Oxygen Cost During Mobility Tasks and Its Relationship to Fatigue in Progressive Multiple Sclerosis</title><title>Archives of physical medicine and rehabilitation</title><addtitle>Arch Phys Med Rehabil</addtitle><description>To compare the oxygen costs of mobility tasks between individuals with progressive multiple sclerosis (MS) using walking aids and matched controls and to determine whether oxygen cost predicted fatigue. Cross-sectional descriptive. A rehabilitation research laboratory. A total of 14 adults with progressive MS (mean age ± SD [y], 54.07±8.46) using walking aids and 8 age- and sex-matched controls without MS (N=22). Participants performed 5 mobility tasks (rolling in bed, lying to sitting, sitting to standing, walking, climbing steps) wearing a portable metabolic cart. Oxygen consumption (V˙o2) during mobility tasks, maximal V˙o2 during graded maximal exercise test, perceived exertion, and task-induced fatigue were measured on a visual analog scale before and after mobility tasks. People with progressive MS had significantly higher oxygen cost in all tasks compared to controls (P<.05): climbing steps (3.60 times more in MS), rolling in bed (3.53), walking (3.10), lying to sitting (2.50), and sitting to standing (1.82). There was a strong, positive correlation between task-induced fatigue and oxygen cost of walking, (ρ [13]=0.626, P=.022). People with progressive MS used 2.81 times more energy on average for mobility tasks compared to controls. People with progressive MS experienced accumulation of oxygen cost, fatigue, and exertion when repeating tasks and higher oxygen cost during walking was related to greater perception of fatigue. Our findings suggest that rehabilitation interventions that increase endurance during functional tasks could help reduce fatigue in people with progressive MS who use walking aids. •People with progressive multiple sclerosis (MS) consume 2.81 times more energy during mobility tasks.•Accumulation of oxygen cost and fatigue suggest deconditioning in persons with MS.•Oxygen cost of walking is a significant predictor of fatigue in progressive MS.</description><subject>Activities of daily living</subject><subject>Cardiovascular deconditioning</subject><subject>Cross-Sectional Studies</subject><subject>Fatigue</subject><subject>Fatigue - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Multiple Sclerosis - rehabilitation</subject><subject>Orthopedic Equipment</subject><subject>Oxygen consumption</subject><subject>Oxygen Consumption - physiology</subject><subject>Physical Exertion - physiology</subject><subject>Physical Therapy Modalities</subject><subject>Rehabilitation</subject><subject>Walking - physiology</subject><issn>0003-9993</issn><issn>1532-821X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9vEzEUxK0KREPhC_RQ-cgli_9svLHEpUpbqNSqCHLgZnntt6nDZr3181bNt8dRCkdOTyPNjOb9CDnnrOKMq8_byo67VAnGdcVkxXhzQmZ8IcV8KfivN2TGGJNzrbU8Je8Rt0WqheTvyKnkTKhayRlxDy_7DQx0FTHTqymFYUPvYxv6kPd0bfE3Ujt4epuR_oDe5hAHfAwjzZHeFLWZgIaBfk9xkwAxPAO9n_ocxh7oT9dDihjwA3nb2R7h4-s9I-ub6_Xq2_zu4evt6vJu7uRC5TK09cp3bMmd61zd1l7LjlttWbeQruFeM97WqnFtJ1rQsgatXbP0jfOddEqekU_H2jHFpwkwm11AB31vB4gTGiG4EpotGS9WcbS6MhATdGZMYWfT3nBmDmzN1hzYmgNbw6QpbEvo4rV_anfg_0X-wiyGL0cDlCefAySDLsDgwIcELhsfw__6_wCuCYyQ</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Devasahayam, Augustine J.</creator><creator>Kelly, Liam P.</creator><creator>Wallack, Elizabeth M.</creator><creator>Ploughman, Michelle</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6618-1543</orcidid><orcidid>https://orcid.org/0000-0002-4594-0077</orcidid></search><sort><creationdate>201911</creationdate><title>Oxygen Cost During Mobility Tasks and Its Relationship to Fatigue in Progressive Multiple Sclerosis</title><author>Devasahayam, Augustine J. ; Kelly, Liam P. ; Wallack, Elizabeth M. ; Ploughman, Michelle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-99bd6df081ccfc4b4d93f1a9a0f53c71d901b467cbf2be934e99c78d7cdf3c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Activities of daily living</topic><topic>Cardiovascular deconditioning</topic><topic>Cross-Sectional Studies</topic><topic>Fatigue</topic><topic>Fatigue - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Multiple Sclerosis - rehabilitation</topic><topic>Orthopedic Equipment</topic><topic>Oxygen consumption</topic><topic>Oxygen Consumption - physiology</topic><topic>Physical Exertion - physiology</topic><topic>Physical Therapy Modalities</topic><topic>Rehabilitation</topic><topic>Walking - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Devasahayam, Augustine J.</creatorcontrib><creatorcontrib>Kelly, Liam P.</creatorcontrib><creatorcontrib>Wallack, Elizabeth M.</creatorcontrib><creatorcontrib>Ploughman, Michelle</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of physical medicine and rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Devasahayam, Augustine J.</au><au>Kelly, Liam P.</au><au>Wallack, Elizabeth M.</au><au>Ploughman, Michelle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxygen Cost During Mobility Tasks and Its Relationship to Fatigue in Progressive Multiple Sclerosis</atitle><jtitle>Archives of physical medicine and rehabilitation</jtitle><addtitle>Arch Phys Med Rehabil</addtitle><date>2019-11</date><risdate>2019</risdate><volume>100</volume><issue>11</issue><spage>2079</spage><epage>2088</epage><pages>2079-2088</pages><issn>0003-9993</issn><eissn>1532-821X</eissn><abstract>To compare the oxygen costs of mobility tasks between individuals with progressive multiple sclerosis (MS) using walking aids and matched controls and to determine whether oxygen cost predicted fatigue. Cross-sectional descriptive. A rehabilitation research laboratory. A total of 14 adults with progressive MS (mean age ± SD [y], 54.07±8.46) using walking aids and 8 age- and sex-matched controls without MS (N=22). Participants performed 5 mobility tasks (rolling in bed, lying to sitting, sitting to standing, walking, climbing steps) wearing a portable metabolic cart. Oxygen consumption (V˙o2) during mobility tasks, maximal V˙o2 during graded maximal exercise test, perceived exertion, and task-induced fatigue were measured on a visual analog scale before and after mobility tasks. People with progressive MS had significantly higher oxygen cost in all tasks compared to controls (P<.05): climbing steps (3.60 times more in MS), rolling in bed (3.53), walking (3.10), lying to sitting (2.50), and sitting to standing (1.82). There was a strong, positive correlation between task-induced fatigue and oxygen cost of walking, (ρ [13]=0.626, P=.022). People with progressive MS used 2.81 times more energy on average for mobility tasks compared to controls. People with progressive MS experienced accumulation of oxygen cost, fatigue, and exertion when repeating tasks and higher oxygen cost during walking was related to greater perception of fatigue. Our findings suggest that rehabilitation interventions that increase endurance during functional tasks could help reduce fatigue in people with progressive MS who use walking aids. •People with progressive multiple sclerosis (MS) consume 2.81 times more energy during mobility tasks.•Accumulation of oxygen cost and fatigue suggest deconditioning in persons with MS.•Oxygen cost of walking is a significant predictor of fatigue in progressive MS.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31026463</pmid><doi>10.1016/j.apmr.2019.03.017</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6618-1543</orcidid><orcidid>https://orcid.org/0000-0002-4594-0077</orcidid></addata></record>
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subjects	Activities of daily living Cardiovascular deconditioning Cross-Sectional Studies Fatigue Fatigue - physiopathology Female Humans Male Multiple sclerosis Multiple Sclerosis - physiopathology Multiple Sclerosis - rehabilitation Orthopedic Equipment Oxygen consumption Oxygen Consumption - physiology Physical Exertion - physiology Physical Therapy Modalities Rehabilitation Walking - physiology
title	Oxygen Cost During Mobility Tasks and Its Relationship to Fatigue in Progressive Multiple Sclerosis
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