Non-Specific Porins of Yersinia pseudotuberculosis as Inductors of Experimental Hyperthyroidism in Mice
In vivo experiments showed that antibodies to OmpC and OmpF porins of Yersinia pseudotuberculosis increased thyroxine (T4) level in the blood of experimental animals. The mice were immunized with different antigens: recombinant OmpF porin in a soluble monomeric form, trimers of OmpC and OmpF porins...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2019-04, Vol.166 (6), p.751-753 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Portnyagina, O. Yu Golotin, V. A. Zelepuga, E. A. Khomenko, V. A. Shevchenko, L. S. Novikova, O. D. |
| description | In vivo
experiments showed that antibodies to OmpC and OmpF porins of
Yersinia pseudotuberculosis
increased thyroxine (T4) level in the blood of experimental animals. The mice were immunized with different antigens: recombinant OmpF porin in a soluble monomeric form, trimers of OmpC and OmpF porins isolated from the outer membrane, or antibodies to them. The level of thyroxine in the blood of mice immunized with OmpF and OmpC porins increased by 5.47 and 22.3 times, respectively; after immunization with antibodies to these proteins, blood thyroxine increased by 9.28 and 14.29 times. Immunization with recombinant OmpF porin induced no reliable increase in thyroxine level. Hence, the serum to recombinant OmpF porin contains no antibodies specific to conformational antigenic determinants that are present in the protein trimer and, according to our previous findings from molecular docking studies, determine cross-reactions between OmpF porin of
Y. pseudotuberculosis
and thyroidstimulating hormone receptor. |
| doi_str_mv | 10.1007/s10517-019-04433-z |
| format | Article |
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experiments showed that antibodies to OmpC and OmpF porins of
Yersinia pseudotuberculosis
increased thyroxine (T4) level in the blood of experimental animals. The mice were immunized with different antigens: recombinant OmpF porin in a soluble monomeric form, trimers of OmpC and OmpF porins isolated from the outer membrane, or antibodies to them. The level of thyroxine in the blood of mice immunized with OmpF and OmpC porins increased by 5.47 and 22.3 times, respectively; after immunization with antibodies to these proteins, blood thyroxine increased by 9.28 and 14.29 times. Immunization with recombinant OmpF porin induced no reliable increase in thyroxine level. Hence, the serum to recombinant OmpF porin contains no antibodies specific to conformational antigenic determinants that are present in the protein trimer and, according to our previous findings from molecular docking studies, determine cross-reactions between OmpF porin of
Y. pseudotuberculosis
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experiments showed that antibodies to OmpC and OmpF porins of
Yersinia pseudotuberculosis
increased thyroxine (T4) level in the blood of experimental animals. The mice were immunized with different antigens: recombinant OmpF porin in a soluble monomeric form, trimers of OmpC and OmpF porins isolated from the outer membrane, or antibodies to them. The level of thyroxine in the blood of mice immunized with OmpF and OmpC porins increased by 5.47 and 22.3 times, respectively; after immunization with antibodies to these proteins, blood thyroxine increased by 9.28 and 14.29 times. Immunization with recombinant OmpF porin induced no reliable increase in thyroxine level. Hence, the serum to recombinant OmpF porin contains no antibodies specific to conformational antigenic determinants that are present in the protein trimer and, according to our previous findings from molecular docking studies, determine cross-reactions between OmpF porin of
Y. pseudotuberculosis
and thyroidstimulating hormone receptor.</description><subject>Antibodies</subject><subject>Antigenic determinants</subject><subject>Antigens</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood</subject><subject>Cell Biology</subject><subject>Electronic components</subject><subject>Hormones</subject><subject>Hyperthyroidism</subject><subject>Immunization</subject><subject>Immunoglobulins</subject><subject>Immunology and Microbiology</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Pathology</subject><subject>Porins</subject><subject>Proteins</subject><subject>Pseudotuberculosis</subject><subject>Thyroid diseases</subject><subject>Thyroid hormones</subject><subject>Thyroxine</subject><subject>Trimers</subject><subject>Yersinia pseudotuberculosis</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kk1v1DAQhi0EokvhD3BAkZBQLyn-iuMcq6q0lcqHBBw4WY4z2XWV2MGTSGx_Pd5uoRQh5IM1nucdzYxfQl4yesword8ioxWrS8qakkopRHnziKxYVYtSc84ekxXNVCm11gfkGeL1LqSKPSUHglGuq1qvyPpDDOXnCZzvvSs-xeQDFrEvvkFCH7wtJoSli_PSQnLLENFjYbG4DN3i5phu2bMfEyQ_QpjtUFxsczBvtin6zuNY-FC89w6ekye9HRBe3N2H5Ou7sy-nF-XVx_PL05Or0kku51IIqXlb19I6aNpG9AJU0wkrVa8aRpkEULJt6sqB5qK2LWOqp9DlbMW7hopDcrSvO6X4fQGczejRwTDYAHFBkxejuFaNqDP6-i_0Oi4p5O52VCWZZhW_p9Z2AONDH-dk3a6oOakapZlWWmTq-B9UPh2M3sUAvc_vDwRv_hBswA7zBuOwzD4GfAjyPehSREzQmynv2qatYdTsbGD2NjDZBubWBuYmi17djba0I3S_Jb_-PQNiD2BOhTWk-9n_U_Ynkuu8EQ</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Portnyagina, O. 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Yu</au><au>Golotin, V. A.</au><au>Zelepuga, E. A.</au><au>Khomenko, V. A.</au><au>Shevchenko, L. S.</au><au>Novikova, O. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-Specific Porins of Yersinia pseudotuberculosis as Inductors of Experimental Hyperthyroidism in Mice</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>166</volume><issue>6</issue><spage>751</spage><epage>753</epage><pages>751-753</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>In vivo
experiments showed that antibodies to OmpC and OmpF porins of
Yersinia pseudotuberculosis
increased thyroxine (T4) level in the blood of experimental animals. The mice were immunized with different antigens: recombinant OmpF porin in a soluble monomeric form, trimers of OmpC and OmpF porins isolated from the outer membrane, or antibodies to them. The level of thyroxine in the blood of mice immunized with OmpF and OmpC porins increased by 5.47 and 22.3 times, respectively; after immunization with antibodies to these proteins, blood thyroxine increased by 9.28 and 14.29 times. Immunization with recombinant OmpF porin induced no reliable increase in thyroxine level. Hence, the serum to recombinant OmpF porin contains no antibodies specific to conformational antigenic determinants that are present in the protein trimer and, according to our previous findings from molecular docking studies, determine cross-reactions between OmpF porin of
Y. pseudotuberculosis
and thyroidstimulating hormone receptor.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31028578</pmid><doi>10.1007/s10517-019-04433-z</doi><tpages>3</tpages></addata></record> |
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| ispartof | Bulletin of experimental biology and medicine, 2019-04, Vol.166 (6), p.751-753 |
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| subjects | Antibodies Antigenic determinants Antigens Biomedical and Life Sciences Biomedicine Blood Cell Biology Electronic components Hormones Hyperthyroidism Immunization Immunoglobulins Immunology and Microbiology Internal Medicine Laboratory Medicine Pathology Porins Proteins Pseudotuberculosis Thyroid diseases Thyroid hormones Thyroxine Trimers Yersinia pseudotuberculosis |
| title | Non-Specific Porins of Yersinia pseudotuberculosis as Inductors of Experimental Hyperthyroidism in Mice |
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