Real-world clinical experience with the percutaneous extracorporeal life support system: Results from the German Lifebridge® Registry
Background The concept of percutaneous extracorporeal life support (ECLS) is based on immediate cardiovascular stabilization allowing for sufficient end-organ perfusion, thus improving the outcome in patients with circulatory arrest. Lifebridge ® (Zoll Medical GmbH, Germany) is a portable ECLS devic...
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| Veröffentlicht in: | Clinical research in cardiology 2020, Vol.109 (1), p.46-53 |
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| creator | Masyuk, Maryna Abel, Peter Hug, Martin Wernly, Bernhard Haneya, Assad Sack, Stefan Sideris, Konstantinos Langwieser, Nicolas Graf, Tobias Fuernau, Georg Franz, Marcus Westenfeld, Ralf Kelm, Malte Felix, Stephan B. Jung, Christian |
| description | Background
The concept of percutaneous extracorporeal life support (ECLS) is based on immediate cardiovascular stabilization allowing for sufficient end-organ perfusion, thus improving the outcome in patients with circulatory arrest. Lifebridge
®
(Zoll Medical GmbH, Germany) is a portable ECLS device designed for rapid application due to its automated set-up.
Methods
A total of 60 tertiary cardiovascular centers were interrogated with regard to application and short-term results after use of Lifebridge ECLS system. Detailed data were collected by standardized case report forms in all centers consented to participate in the study. Demographic and clinical baseline characteristics of the patient population, procedural and follow-up data were recorded and analyzed.
Results
In total, 444 patients were analyzed regarding mortality. The detailed study cohort consisted of 112 patients. A total of 80% of the study subjects represented patients post cardiopulmonary resuscitation, 43% were in cardiogenic shock and 50% suffered from acute myocardial infarction. The survival rates were 36% immediately after device implementation and 16% after 30 days. Multivariable analysis revealed that only serum lactate concentration at admission could be proven as independent predictor of patients’ outcome. Patients with lactate concentrations above 10 mmol/L exhibited > 95% mortality (
p
|
| doi_str_mv | 10.1007/s00392-019-01482-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2216286888</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2215418252</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-37bf47377918982a41e740952205c78a6aed8fd9aa12e7b0f6b55f3418dd13253</originalsourceid><addsrcrecordid>eNp9kc9KHTEUxkOpVGv7Ai4k0I2bafNnMsm4E7G2cKEgug6ZzJlrJPOnSQa9L-Dj-BA-WXMdteDCRUhOzu_7ksOH0AEl3ykh8kckhNesILTOq1SsYB_QHlUVLUhVs4-vZ1Xuos8x3hAiKOHlJ7TLKWGqlGIP3V-A8cXtGHyLrXeDs8ZjuJsgOBgs4FuXrnG6Bpxv7JzMAOMcM5CCsWOYxpDl2LsOcJynXCYcNzFBf4wvIM4-RdyFsX9yOIfQmwGvMtwE167h8SFDaxdT2HxBO53xEb4-7_vo6ufZ5emvYvXn_PfpyaqwXIpUcNl0peRS1lTVipmSgixJLRgjwkplKgOt6traGMpANqSrGiE6XlLVtpQzwffR0eI7hfHvDDHp3kUL3i-DacZoxVSllMrotzfozTiHIf9uS4nsyQTLFFsoG8YYA3R6Cq43YaMp0duU9JKSzinpp5T0VnT4bD03PbSvkpdYMsAXIObWsIbw_-13bP8B5IGfVw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2215418252</pqid></control><display><type>article</type><title>Real-world clinical experience with the percutaneous extracorporeal life support system: Results from the German Lifebridge® Registry</title><source>Springer Nature - Complete Springer Journals</source><creator>Masyuk, Maryna ; Abel, Peter ; Hug, Martin ; Wernly, Bernhard ; Haneya, Assad ; Sack, Stefan ; Sideris, Konstantinos ; Langwieser, Nicolas ; Graf, Tobias ; Fuernau, Georg ; Franz, Marcus ; Westenfeld, Ralf ; Kelm, Malte ; Felix, Stephan B. ; Jung, Christian</creator><creatorcontrib>Masyuk, Maryna ; Abel, Peter ; Hug, Martin ; Wernly, Bernhard ; Haneya, Assad ; Sack, Stefan ; Sideris, Konstantinos ; Langwieser, Nicolas ; Graf, Tobias ; Fuernau, Georg ; Franz, Marcus ; Westenfeld, Ralf ; Kelm, Malte ; Felix, Stephan B. ; Jung, Christian</creatorcontrib><description>Background
The concept of percutaneous extracorporeal life support (ECLS) is based on immediate cardiovascular stabilization allowing for sufficient end-organ perfusion, thus improving the outcome in patients with circulatory arrest. Lifebridge
®
(Zoll Medical GmbH, Germany) is a portable ECLS device designed for rapid application due to its automated set-up.
Methods
A total of 60 tertiary cardiovascular centers were interrogated with regard to application and short-term results after use of Lifebridge ECLS system. Detailed data were collected by standardized case report forms in all centers consented to participate in the study. Demographic and clinical baseline characteristics of the patient population, procedural and follow-up data were recorded and analyzed.
Results
In total, 444 patients were analyzed regarding mortality. The detailed study cohort consisted of 112 patients. A total of 80% of the study subjects represented patients post cardiopulmonary resuscitation, 43% were in cardiogenic shock and 50% suffered from acute myocardial infarction. The survival rates were 36% immediately after device implementation and 16% after 30 days. Multivariable analysis revealed that only serum lactate concentration at admission could be proven as independent predictor of patients’ outcome. Patients with lactate concentrations above 10 mmol/L exhibited > 95% mortality (
p
< 0.05 versus below 10 mmol/L).
Conclusion
The present study provides real-world clinical data of patients treated with a transportable automated ECLS system. In conclusion, Lifebridge is a safely applicable cardiorespiratory stabilization tool associated with acceptable complication rates. Nevertheless, mortality rates were high in these critically ill patients, especially in those showing high lactate concentrations at admission.</description><identifier>ISSN: 1861-0684</identifier><identifier>EISSN: 1861-0692</identifier><identifier>DOI: 10.1007/s00392-019-01482-2</identifier><identifier>PMID: 31028475</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Automation ; Cardiac arrest ; Cardiology ; Demographics ; Lactic acid ; Life support systems ; Medicine ; Medicine & Public Health ; Mortality ; Myocardial infarction ; Original Paper ; Patients ; Perfusion ; Portable equipment ; Resuscitation ; Stabilization</subject><ispartof>Clinical research in cardiology, 2020, Vol.109 (1), p.46-53</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Clinical Research in Cardiology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-37bf47377918982a41e740952205c78a6aed8fd9aa12e7b0f6b55f3418dd13253</citedby><cites>FETCH-LOGICAL-c375t-37bf47377918982a41e740952205c78a6aed8fd9aa12e7b0f6b55f3418dd13253</cites><orcidid>0000-0003-4024-0220</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00392-019-01482-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00392-019-01482-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31028475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masyuk, Maryna</creatorcontrib><creatorcontrib>Abel, Peter</creatorcontrib><creatorcontrib>Hug, Martin</creatorcontrib><creatorcontrib>Wernly, Bernhard</creatorcontrib><creatorcontrib>Haneya, Assad</creatorcontrib><creatorcontrib>Sack, Stefan</creatorcontrib><creatorcontrib>Sideris, Konstantinos</creatorcontrib><creatorcontrib>Langwieser, Nicolas</creatorcontrib><creatorcontrib>Graf, Tobias</creatorcontrib><creatorcontrib>Fuernau, Georg</creatorcontrib><creatorcontrib>Franz, Marcus</creatorcontrib><creatorcontrib>Westenfeld, Ralf</creatorcontrib><creatorcontrib>Kelm, Malte</creatorcontrib><creatorcontrib>Felix, Stephan B.</creatorcontrib><creatorcontrib>Jung, Christian</creatorcontrib><title>Real-world clinical experience with the percutaneous extracorporeal life support system: Results from the German Lifebridge® Registry</title><title>Clinical research in cardiology</title><addtitle>Clin Res Cardiol</addtitle><addtitle>Clin Res Cardiol</addtitle><description>Background
The concept of percutaneous extracorporeal life support (ECLS) is based on immediate cardiovascular stabilization allowing for sufficient end-organ perfusion, thus improving the outcome in patients with circulatory arrest. Lifebridge
®
(Zoll Medical GmbH, Germany) is a portable ECLS device designed for rapid application due to its automated set-up.
Methods
A total of 60 tertiary cardiovascular centers were interrogated with regard to application and short-term results after use of Lifebridge ECLS system. Detailed data were collected by standardized case report forms in all centers consented to participate in the study. Demographic and clinical baseline characteristics of the patient population, procedural and follow-up data were recorded and analyzed.
Results
In total, 444 patients were analyzed regarding mortality. The detailed study cohort consisted of 112 patients. A total of 80% of the study subjects represented patients post cardiopulmonary resuscitation, 43% were in cardiogenic shock and 50% suffered from acute myocardial infarction. The survival rates were 36% immediately after device implementation and 16% after 30 days. Multivariable analysis revealed that only serum lactate concentration at admission could be proven as independent predictor of patients’ outcome. Patients with lactate concentrations above 10 mmol/L exhibited > 95% mortality (
p
< 0.05 versus below 10 mmol/L).
Conclusion
The present study provides real-world clinical data of patients treated with a transportable automated ECLS system. In conclusion, Lifebridge is a safely applicable cardiorespiratory stabilization tool associated with acceptable complication rates. Nevertheless, mortality rates were high in these critically ill patients, especially in those showing high lactate concentrations at admission.</description><subject>Automation</subject><subject>Cardiac arrest</subject><subject>Cardiology</subject><subject>Demographics</subject><subject>Lactic acid</subject><subject>Life support systems</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Original Paper</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Portable equipment</subject><subject>Resuscitation</subject><subject>Stabilization</subject><issn>1861-0684</issn><issn>1861-0692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kc9KHTEUxkOpVGv7Ai4k0I2bafNnMsm4E7G2cKEgug6ZzJlrJPOnSQa9L-Dj-BA-WXMdteDCRUhOzu_7ksOH0AEl3ykh8kckhNesILTOq1SsYB_QHlUVLUhVs4-vZ1Xuos8x3hAiKOHlJ7TLKWGqlGIP3V-A8cXtGHyLrXeDs8ZjuJsgOBgs4FuXrnG6Bpxv7JzMAOMcM5CCsWOYxpDl2LsOcJynXCYcNzFBf4wvIM4-RdyFsX9yOIfQmwGvMtwE167h8SFDaxdT2HxBO53xEb4-7_vo6ufZ5emvYvXn_PfpyaqwXIpUcNl0peRS1lTVipmSgixJLRgjwkplKgOt6traGMpANqSrGiE6XlLVtpQzwffR0eI7hfHvDDHp3kUL3i-DacZoxVSllMrotzfozTiHIf9uS4nsyQTLFFsoG8YYA3R6Cq43YaMp0duU9JKSzinpp5T0VnT4bD03PbSvkpdYMsAXIObWsIbw_-13bP8B5IGfVw</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Masyuk, Maryna</creator><creator>Abel, Peter</creator><creator>Hug, Martin</creator><creator>Wernly, Bernhard</creator><creator>Haneya, Assad</creator><creator>Sack, Stefan</creator><creator>Sideris, Konstantinos</creator><creator>Langwieser, Nicolas</creator><creator>Graf, Tobias</creator><creator>Fuernau, Georg</creator><creator>Franz, Marcus</creator><creator>Westenfeld, Ralf</creator><creator>Kelm, Malte</creator><creator>Felix, Stephan B.</creator><creator>Jung, Christian</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4024-0220</orcidid></search><sort><creationdate>2020</creationdate><title>Real-world clinical experience with the percutaneous extracorporeal life support system: Results from the German Lifebridge® Registry</title><author>Masyuk, Maryna ; Abel, Peter ; Hug, Martin ; Wernly, Bernhard ; Haneya, Assad ; Sack, Stefan ; Sideris, Konstantinos ; Langwieser, Nicolas ; Graf, Tobias ; Fuernau, Georg ; Franz, Marcus ; Westenfeld, Ralf ; Kelm, Malte ; Felix, Stephan B. ; Jung, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-37bf47377918982a41e740952205c78a6aed8fd9aa12e7b0f6b55f3418dd13253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Automation</topic><topic>Cardiac arrest</topic><topic>Cardiology</topic><topic>Demographics</topic><topic>Lactic acid</topic><topic>Life support systems</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Original Paper</topic><topic>Patients</topic><topic>Perfusion</topic><topic>Portable equipment</topic><topic>Resuscitation</topic><topic>Stabilization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masyuk, Maryna</creatorcontrib><creatorcontrib>Abel, Peter</creatorcontrib><creatorcontrib>Hug, Martin</creatorcontrib><creatorcontrib>Wernly, Bernhard</creatorcontrib><creatorcontrib>Haneya, Assad</creatorcontrib><creatorcontrib>Sack, Stefan</creatorcontrib><creatorcontrib>Sideris, Konstantinos</creatorcontrib><creatorcontrib>Langwieser, Nicolas</creatorcontrib><creatorcontrib>Graf, Tobias</creatorcontrib><creatorcontrib>Fuernau, Georg</creatorcontrib><creatorcontrib>Franz, Marcus</creatorcontrib><creatorcontrib>Westenfeld, Ralf</creatorcontrib><creatorcontrib>Kelm, Malte</creatorcontrib><creatorcontrib>Felix, Stephan B.</creatorcontrib><creatorcontrib>Jung, Christian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical research in cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masyuk, Maryna</au><au>Abel, Peter</au><au>Hug, Martin</au><au>Wernly, Bernhard</au><au>Haneya, Assad</au><au>Sack, Stefan</au><au>Sideris, Konstantinos</au><au>Langwieser, Nicolas</au><au>Graf, Tobias</au><au>Fuernau, Georg</au><au>Franz, Marcus</au><au>Westenfeld, Ralf</au><au>Kelm, Malte</au><au>Felix, Stephan B.</au><au>Jung, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Real-world clinical experience with the percutaneous extracorporeal life support system: Results from the German Lifebridge® Registry</atitle><jtitle>Clinical research in cardiology</jtitle><stitle>Clin Res Cardiol</stitle><addtitle>Clin Res Cardiol</addtitle><date>2020</date><risdate>2020</risdate><volume>109</volume><issue>1</issue><spage>46</spage><epage>53</epage><pages>46-53</pages><issn>1861-0684</issn><eissn>1861-0692</eissn><abstract>Background
The concept of percutaneous extracorporeal life support (ECLS) is based on immediate cardiovascular stabilization allowing for sufficient end-organ perfusion, thus improving the outcome in patients with circulatory arrest. Lifebridge
®
(Zoll Medical GmbH, Germany) is a portable ECLS device designed for rapid application due to its automated set-up.
Methods
A total of 60 tertiary cardiovascular centers were interrogated with regard to application and short-term results after use of Lifebridge ECLS system. Detailed data were collected by standardized case report forms in all centers consented to participate in the study. Demographic and clinical baseline characteristics of the patient population, procedural and follow-up data were recorded and analyzed.
Results
In total, 444 patients were analyzed regarding mortality. The detailed study cohort consisted of 112 patients. A total of 80% of the study subjects represented patients post cardiopulmonary resuscitation, 43% were in cardiogenic shock and 50% suffered from acute myocardial infarction. The survival rates were 36% immediately after device implementation and 16% after 30 days. Multivariable analysis revealed that only serum lactate concentration at admission could be proven as independent predictor of patients’ outcome. Patients with lactate concentrations above 10 mmol/L exhibited > 95% mortality (
p
< 0.05 versus below 10 mmol/L).
Conclusion
The present study provides real-world clinical data of patients treated with a transportable automated ECLS system. In conclusion, Lifebridge is a safely applicable cardiorespiratory stabilization tool associated with acceptable complication rates. Nevertheless, mortality rates were high in these critically ill patients, especially in those showing high lactate concentrations at admission.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31028475</pmid><doi>10.1007/s00392-019-01482-2</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4024-0220</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical research in cardiology, 2020, Vol.109 (1), p.46-53 |
| issn | 1861-0684 1861-0692 |
| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Automation Cardiac arrest Cardiology Demographics Lactic acid Life support systems Medicine Medicine & Public Health Mortality Myocardial infarction Original Paper Patients Perfusion Portable equipment Resuscitation Stabilization |
| title | Real-world clinical experience with the percutaneous extracorporeal life support system: Results from the German Lifebridge® Registry |
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