Radiologic features of pneumonitis associated with nivolumab in non-small-cell lung cancer and malignant melanoma
To assess the clinical features/imaging characteristics of pneumonitis reported during nationwide nivolumab postmarketing surveillance in Japan. Clinical and radiological data were collected from pneumonitis cases reported during/after nivolumab treatment for melanoma or non-small-cell lung cancer....
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| Veröffentlicht in: | Future oncology (London, England) England), 2019-06, Vol.15 (16), p.1911-1920 |
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| container_title | Future oncology (London, England) |
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| creator | Baba, Tomohisa Akai, Fumikazu S Kato, Terufumi Kusumoto, Masahiko Kenmotsu, Hirotsugu Sugiura, Hiroaki Tominaga, Junya Oikado, Katsunori Sata, Masafumi Endo, Masahiro Yanagawa, Noriyo Sasaki, Shinichi Iwasawa, Tae Saito, Yoshinobu Fujiwara, Yutaka Ohe, Yuichiro Yamazaki, Naoya Sakamoto, Takahiko Koshiba, Takashi Kuwano, Kazuyoshi |
| description | To assess the clinical features/imaging characteristics of pneumonitis reported during nationwide nivolumab postmarketing surveillance in Japan.
Clinical and radiological data were collected from pneumonitis cases reported during/after nivolumab treatment for melanoma or non-small-cell lung cancer. The expert central review committee evaluated each case.
Among 144 cases analyzed, 91 (63.2%) had radiological patterns considered typical for drug-induced pneumonitis and 53 (36.8%) patients had previously unobserved patterns with one or more atypical features, including 23 cases (16.0%) with ground glass opacity confined to the area around the tumor (peritumoral infiltration). A higher proportion of patients with (vs without) peritumoral infiltration had an antitumor response to nivolumab.
Images of nivolumab-induced pneumonitis showed previously unobserved radiological patterns. |
| doi_str_mv | 10.2217/fon-2019-0102 |
| format | Article |
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Clinical and radiological data were collected from pneumonitis cases reported during/after nivolumab treatment for melanoma or non-small-cell lung cancer. The expert central review committee evaluated each case.
Among 144 cases analyzed, 91 (63.2%) had radiological patterns considered typical for drug-induced pneumonitis and 53 (36.8%) patients had previously unobserved patterns with one or more atypical features, including 23 cases (16.0%) with ground glass opacity confined to the area around the tumor (peritumoral infiltration). A higher proportion of patients with (vs without) peritumoral infiltration had an antitumor response to nivolumab.
Images of nivolumab-induced pneumonitis showed previously unobserved radiological patterns.</description><identifier>ISSN: 1479-6694</identifier><identifier>EISSN: 1744-8301</identifier><identifier>DOI: 10.2217/fon-2019-0102</identifier><identifier>PMID: 31020849</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Cancer therapies ; Clinical trials ; Epidermal growth factor ; immune checkpoint inhibitor ; Immunotherapy ; Injuries ; interstitial lung disease ; Lung cancer ; Lung diseases ; Medical diagnosis ; Melanoma ; Metastasis ; Monoclonal antibodies ; nivolumab ; Patients ; PD-1 inhibitor ; Pneumonia ; pneumonitis ; Radiation therapy ; Skin cancer ; Targeted cancer therapy ; Validity</subject><ispartof>Future oncology (London, England), 2019-06, Vol.15 (16), p.1911-1920</ispartof><rights>2019 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Jun 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-2ab7a9065533ea95b2ce90cfb5c81f5bb890534b4915280782d5f05d971a51de3</citedby><cites>FETCH-LOGICAL-c410t-2ab7a9065533ea95b2ce90cfb5c81f5bb890534b4915280782d5f05d971a51de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31020849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baba, Tomohisa</creatorcontrib><creatorcontrib>Akai, Fumikazu S</creatorcontrib><creatorcontrib>Kato, Terufumi</creatorcontrib><creatorcontrib>Kusumoto, Masahiko</creatorcontrib><creatorcontrib>Kenmotsu, Hirotsugu</creatorcontrib><creatorcontrib>Sugiura, Hiroaki</creatorcontrib><creatorcontrib>Tominaga, Junya</creatorcontrib><creatorcontrib>Oikado, Katsunori</creatorcontrib><creatorcontrib>Sata, Masafumi</creatorcontrib><creatorcontrib>Endo, Masahiro</creatorcontrib><creatorcontrib>Yanagawa, Noriyo</creatorcontrib><creatorcontrib>Sasaki, Shinichi</creatorcontrib><creatorcontrib>Iwasawa, Tae</creatorcontrib><creatorcontrib>Saito, Yoshinobu</creatorcontrib><creatorcontrib>Fujiwara, Yutaka</creatorcontrib><creatorcontrib>Ohe, Yuichiro</creatorcontrib><creatorcontrib>Yamazaki, Naoya</creatorcontrib><creatorcontrib>Sakamoto, Takahiko</creatorcontrib><creatorcontrib>Koshiba, Takashi</creatorcontrib><creatorcontrib>Kuwano, Kazuyoshi</creatorcontrib><title>Radiologic features of pneumonitis associated with nivolumab in non-small-cell lung cancer and malignant melanoma</title><title>Future oncology (London, England)</title><addtitle>Future Oncol</addtitle><description>To assess the clinical features/imaging characteristics of pneumonitis reported during nationwide nivolumab postmarketing surveillance in Japan.
Clinical and radiological data were collected from pneumonitis cases reported during/after nivolumab treatment for melanoma or non-small-cell lung cancer. The expert central review committee evaluated each case.
Among 144 cases analyzed, 91 (63.2%) had radiological patterns considered typical for drug-induced pneumonitis and 53 (36.8%) patients had previously unobserved patterns with one or more atypical features, including 23 cases (16.0%) with ground glass opacity confined to the area around the tumor (peritumoral infiltration). A higher proportion of patients with (vs without) peritumoral infiltration had an antitumor response to nivolumab.
Images of nivolumab-induced pneumonitis showed previously unobserved radiological patterns.</description><subject>Cancer therapies</subject><subject>Clinical trials</subject><subject>Epidermal growth factor</subject><subject>immune checkpoint inhibitor</subject><subject>Immunotherapy</subject><subject>Injuries</subject><subject>interstitial lung disease</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Medical diagnosis</subject><subject>Melanoma</subject><subject>Metastasis</subject><subject>Monoclonal antibodies</subject><subject>nivolumab</subject><subject>Patients</subject><subject>PD-1 inhibitor</subject><subject>Pneumonia</subject><subject>pneumonitis</subject><subject>Radiation therapy</subject><subject>Skin cancer</subject><subject>Targeted cancer therapy</subject><subject>Validity</subject><issn>1479-6694</issn><issn>1744-8301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kUuLFDEUhYMozkOXbiXgxk305tWpLGUYdWBAEF0Xt1JJmyGV9FQqiv_etD26EFzdXPLl5HAOIS84vBGCm7ehZCaAWwYcxCNyzo1SbJDAH_ezMpbtdladkYta7wCUkRqekjPZWRiUPSf3n3GOJZV9dDR43NrqKy2BHrJvS8lxi5VircVF3PxMf8TtG83xe0ltwYnGTHP_vy6YEnM-JZpa3lOH2fmVYp5pv4n7jHmji0-Yy4LPyJOAqfrnD_OSfH1__eXqI7v99OHm6t0tc4rDxgROBi3stJbSo9WTcN6CC5N2Aw96mgYLWqpJWa7FAGYQsw6gZ2s4aj57eUlen3QPa7lvvm7jEuvRI2ZfWh17ehqEHbTp6Kt_0LvS1tzddcpIISTf8U6xE-XWUuvqw3hY44Lrz5HDUc2MvYvx2MV47KLzLx9U27T4-S_9J_wO2BMQ2u_cXfQ9t_G09RfRxez_I_4LjLCY5g</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Baba, Tomohisa</creator><creator>Akai, Fumikazu S</creator><creator>Kato, Terufumi</creator><creator>Kusumoto, Masahiko</creator><creator>Kenmotsu, Hirotsugu</creator><creator>Sugiura, Hiroaki</creator><creator>Tominaga, Junya</creator><creator>Oikado, Katsunori</creator><creator>Sata, Masafumi</creator><creator>Endo, Masahiro</creator><creator>Yanagawa, Noriyo</creator><creator>Sasaki, Shinichi</creator><creator>Iwasawa, Tae</creator><creator>Saito, Yoshinobu</creator><creator>Fujiwara, Yutaka</creator><creator>Ohe, Yuichiro</creator><creator>Yamazaki, Naoya</creator><creator>Sakamoto, Takahiko</creator><creator>Koshiba, Takashi</creator><creator>Kuwano, Kazuyoshi</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190601</creationdate><title>Radiologic features of pneumonitis associated with nivolumab in non-small-cell lung cancer and malignant melanoma</title><author>Baba, Tomohisa ; 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Clinical and radiological data were collected from pneumonitis cases reported during/after nivolumab treatment for melanoma or non-small-cell lung cancer. The expert central review committee evaluated each case.
Among 144 cases analyzed, 91 (63.2%) had radiological patterns considered typical for drug-induced pneumonitis and 53 (36.8%) patients had previously unobserved patterns with one or more atypical features, including 23 cases (16.0%) with ground glass opacity confined to the area around the tumor (peritumoral infiltration). A higher proportion of patients with (vs without) peritumoral infiltration had an antitumor response to nivolumab.
Images of nivolumab-induced pneumonitis showed previously unobserved radiological patterns.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>31020849</pmid><doi>10.2217/fon-2019-0102</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cancer therapies Clinical trials Epidermal growth factor immune checkpoint inhibitor Immunotherapy Injuries interstitial lung disease Lung cancer Lung diseases Medical diagnosis Melanoma Metastasis Monoclonal antibodies nivolumab Patients PD-1 inhibitor Pneumonia pneumonitis Radiation therapy Skin cancer Targeted cancer therapy Validity |
| title | Radiologic features of pneumonitis associated with nivolumab in non-small-cell lung cancer and malignant melanoma |
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