Widespread neonatal infection with phocid herpesvirus 1 in free-ranging and stranded grey seals Halichoerus grypus
Phocid herpesvirus 1 (PhHV-1) is known to infect grey seals Halichoerus grypus but little is known about its pathogenicity or true prevalence in this species. To investigate the prevalence of and risk factors associated with PHV-1 infection, nasal swabs were collected from grey seal pups and yearlin...
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| Veröffentlicht in: | Diseases of aquatic organisms 2019-03, Vol.133 (3), p.181-187 |
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| creator | Baily, Johanna L Willoughby, Kim Maley, Madeleine Chapman, Jacob Pizzi, Romain Hall, Ailsa J Dagleish, Mark P |
| description | Phocid herpesvirus 1 (PhHV-1) is known to infect grey seals Halichoerus grypus but little is known about its pathogenicity or true prevalence in this species. To investigate the prevalence of and risk factors associated with PHV-1 infection, nasal swabs were collected from grey seal pups and yearlings on the Isle of May, a well-studied grey seal breeding colony, and from stranded grey seal pups submitted to a rehabilitation centre. PhHV-1 nucleic acids were detected in nasal swabs from 58% (52/90) of live free-ranging grey seal pups, 62% (18/29) of live stranded grey seal pups and 28% (5/18) of live free-ranging yearlings, suggesting recrudescence in the latter. Location within the colony, pup body mass and stranding were determined to be risk factors for shedding PhHV-1 in live seal pups with a significantly higher prevalence of PhHV-1 in pups born on the tidal boulder beach when compared to other sites; a significantly positive correlation of PhHV-1 shedding and pup body mass and a higher prevalence in stranded grey seal pups compared to their free-ranging conspecifics. The prevalence of PhHV1 in dead pups on the Isle of May was 56% (27/48) with a positive PhHV-1 PCR status significantly associated with hepatic necrosis (p = 0.01), thymic atrophy (p < 0.001) and buccal ulceration (p = 0.027). Results indicate that PhHV1 was widespread in the pups in the Isle of May grey seal breeding colony. |
| doi_str_mv | 10.3354/dao03345 |
| format | Article |
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To investigate the prevalence of and risk factors associated with PHV-1 infection, nasal swabs were collected from grey seal pups and yearlings on the Isle of May, a well-studied grey seal breeding colony, and from stranded grey seal pups submitted to a rehabilitation centre. PhHV-1 nucleic acids were detected in nasal swabs from 58% (52/90) of live free-ranging grey seal pups, 62% (18/29) of live stranded grey seal pups and 28% (5/18) of live free-ranging yearlings, suggesting recrudescence in the latter. Location within the colony, pup body mass and stranding were determined to be risk factors for shedding PhHV-1 in live seal pups with a significantly higher prevalence of PhHV-1 in pups born on the tidal boulder beach when compared to other sites; a significantly positive correlation of PhHV-1 shedding and pup body mass and a higher prevalence in stranded grey seal pups compared to their free-ranging conspecifics. The prevalence of PhHV1 in dead pups on the Isle of May was 56% (27/48) with a positive PhHV-1 PCR status significantly associated with hepatic necrosis (p = 0.01), thymic atrophy (p < 0.001) and buccal ulceration (p = 0.027). Results indicate that PhHV1 was widespread in the pups in the Isle of May grey seal breeding colony.</description><identifier>ISSN: 0177-5103</identifier><identifier>EISSN: 1616-1580</identifier><identifier>DOI: 10.3354/dao03345</identifier><identifier>PMID: 31019131</identifier><language>eng</language><publisher>Germany: Inter-Research Science Center</publisher><subject>Atrophy ; Body mass ; Breeding ; Colonies ; Conspecifics ; Grey seals ; Halichoerus grypus ; Health risks ; Infections ; Necrosis ; Neonates ; Nucleic acids ; Pathogenicity ; Pathogens ; Rehabilitation ; Risk analysis ; Risk factors ; Seals ; Shedding ; Stranding ; Thymus ; Wildlife conservation</subject><ispartof>Diseases of aquatic organisms, 2019-03, Vol.133 (3), p.181-187</ispartof><rights>Copyright Inter-Research Science Center 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-c8eca93d3978b7a80f0025fcdadbfd93169e9a6d8b41d2ec7bcdc55b1ef7c1cd3</citedby><cites>FETCH-LOGICAL-c345t-c8eca93d3978b7a80f0025fcdadbfd93169e9a6d8b41d2ec7bcdc55b1ef7c1cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3759,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31019131$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baily, Johanna L</creatorcontrib><creatorcontrib>Willoughby, Kim</creatorcontrib><creatorcontrib>Maley, Madeleine</creatorcontrib><creatorcontrib>Chapman, Jacob</creatorcontrib><creatorcontrib>Pizzi, Romain</creatorcontrib><creatorcontrib>Hall, Ailsa J</creatorcontrib><creatorcontrib>Dagleish, Mark P</creatorcontrib><title>Widespread neonatal infection with phocid herpesvirus 1 in free-ranging and stranded grey seals Halichoerus grypus</title><title>Diseases of aquatic organisms</title><addtitle>Dis Aquat Organ</addtitle><description>Phocid herpesvirus 1 (PhHV-1) is known to infect grey seals Halichoerus grypus but little is known about its pathogenicity or true prevalence in this species. To investigate the prevalence of and risk factors associated with PHV-1 infection, nasal swabs were collected from grey seal pups and yearlings on the Isle of May, a well-studied grey seal breeding colony, and from stranded grey seal pups submitted to a rehabilitation centre. PhHV-1 nucleic acids were detected in nasal swabs from 58% (52/90) of live free-ranging grey seal pups, 62% (18/29) of live stranded grey seal pups and 28% (5/18) of live free-ranging yearlings, suggesting recrudescence in the latter. Location within the colony, pup body mass and stranding were determined to be risk factors for shedding PhHV-1 in live seal pups with a significantly higher prevalence of PhHV-1 in pups born on the tidal boulder beach when compared to other sites; a significantly positive correlation of PhHV-1 shedding and pup body mass and a higher prevalence in stranded grey seal pups compared to their free-ranging conspecifics. The prevalence of PhHV1 in dead pups on the Isle of May was 56% (27/48) with a positive PhHV-1 PCR status significantly associated with hepatic necrosis (p = 0.01), thymic atrophy (p < 0.001) and buccal ulceration (p = 0.027). Results indicate that PhHV1 was widespread in the pups in the Isle of May grey seal breeding colony.</description><subject>Atrophy</subject><subject>Body mass</subject><subject>Breeding</subject><subject>Colonies</subject><subject>Conspecifics</subject><subject>Grey seals</subject><subject>Halichoerus grypus</subject><subject>Health risks</subject><subject>Infections</subject><subject>Necrosis</subject><subject>Neonates</subject><subject>Nucleic acids</subject><subject>Pathogenicity</subject><subject>Pathogens</subject><subject>Rehabilitation</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Seals</subject><subject>Shedding</subject><subject>Stranding</subject><subject>Thymus</subject><subject>Wildlife conservation</subject><issn>0177-5103</issn><issn>1616-1580</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpdkdFLwzAQxoMobk7Bv0ACvvhSzTVL2zzKUCcMfFF8LGlybTO6tiatsv_eDDcFn47jfvdx332EXAK75VzM74zqGOdzcUSmkEASgcjYMZkySNNIAOMTcub9mjGIpYBTMuHAQAKHKXHv1qDvHSpDW-xaNaiG2rZEPdiupV92qGlfd9oaWqPr0X9aN3oKgaGlQ4ycaivbVlS1hvohdAYNrRxuqUfVeLpUjdV1h7utym370Z-TkzJM8GJfZ-Tt8eF1sYxWL0_Pi_tVpIOTIdIZaiW54TLNilRlrGQsFqU2yhSlkRwSiVIlJivmYGLUaaGNFqIALFMN2vAZufnR7V33MaIf8o31GptGBaOjz-MYBIsTLmVAr_-h6250bbguUCwFnkqW_Alq13nvsMx7ZzfKbXNg-S6H_JBDQK_2gmOxQfMLHh7PvwFCHIUw</recordid><startdate>20190314</startdate><enddate>20190314</enddate><creator>Baily, Johanna L</creator><creator>Willoughby, Kim</creator><creator>Maley, Madeleine</creator><creator>Chapman, Jacob</creator><creator>Pizzi, Romain</creator><creator>Hall, Ailsa J</creator><creator>Dagleish, Mark P</creator><general>Inter-Research Science Center</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20190314</creationdate><title>Widespread neonatal infection with phocid herpesvirus 1 in free-ranging and stranded grey seals Halichoerus grypus</title><author>Baily, Johanna L ; Willoughby, Kim ; Maley, Madeleine ; Chapman, Jacob ; Pizzi, Romain ; Hall, Ailsa J ; Dagleish, Mark P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-c8eca93d3978b7a80f0025fcdadbfd93169e9a6d8b41d2ec7bcdc55b1ef7c1cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Atrophy</topic><topic>Body mass</topic><topic>Breeding</topic><topic>Colonies</topic><topic>Conspecifics</topic><topic>Grey seals</topic><topic>Halichoerus grypus</topic><topic>Health risks</topic><topic>Infections</topic><topic>Necrosis</topic><topic>Neonates</topic><topic>Nucleic acids</topic><topic>Pathogenicity</topic><topic>Pathogens</topic><topic>Rehabilitation</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Seals</topic><topic>Shedding</topic><topic>Stranding</topic><topic>Thymus</topic><topic>Wildlife conservation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baily, Johanna L</creatorcontrib><creatorcontrib>Willoughby, Kim</creatorcontrib><creatorcontrib>Maley, Madeleine</creatorcontrib><creatorcontrib>Chapman, Jacob</creatorcontrib><creatorcontrib>Pizzi, Romain</creatorcontrib><creatorcontrib>Hall, Ailsa J</creatorcontrib><creatorcontrib>Dagleish, Mark P</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Diseases of aquatic organisms</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baily, Johanna L</au><au>Willoughby, Kim</au><au>Maley, Madeleine</au><au>Chapman, Jacob</au><au>Pizzi, Romain</au><au>Hall, Ailsa J</au><au>Dagleish, Mark P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Widespread neonatal infection with phocid herpesvirus 1 in free-ranging and stranded grey seals Halichoerus grypus</atitle><jtitle>Diseases of aquatic organisms</jtitle><addtitle>Dis Aquat Organ</addtitle><date>2019-03-14</date><risdate>2019</risdate><volume>133</volume><issue>3</issue><spage>181</spage><epage>187</epage><pages>181-187</pages><issn>0177-5103</issn><eissn>1616-1580</eissn><abstract>Phocid herpesvirus 1 (PhHV-1) is known to infect grey seals Halichoerus grypus but little is known about its pathogenicity or true prevalence in this species. To investigate the prevalence of and risk factors associated with PHV-1 infection, nasal swabs were collected from grey seal pups and yearlings on the Isle of May, a well-studied grey seal breeding colony, and from stranded grey seal pups submitted to a rehabilitation centre. PhHV-1 nucleic acids were detected in nasal swabs from 58% (52/90) of live free-ranging grey seal pups, 62% (18/29) of live stranded grey seal pups and 28% (5/18) of live free-ranging yearlings, suggesting recrudescence in the latter. Location within the colony, pup body mass and stranding were determined to be risk factors for shedding PhHV-1 in live seal pups with a significantly higher prevalence of PhHV-1 in pups born on the tidal boulder beach when compared to other sites; a significantly positive correlation of PhHV-1 shedding and pup body mass and a higher prevalence in stranded grey seal pups compared to their free-ranging conspecifics. The prevalence of PhHV1 in dead pups on the Isle of May was 56% (27/48) with a positive PhHV-1 PCR status significantly associated with hepatic necrosis (p = 0.01), thymic atrophy (p < 0.001) and buccal ulceration (p = 0.027). Results indicate that PhHV1 was widespread in the pups in the Isle of May grey seal breeding colony.</abstract><cop>Germany</cop><pub>Inter-Research Science Center</pub><pmid>31019131</pmid><doi>10.3354/dao03345</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diseases of aquatic organisms, 2019-03, Vol.133 (3), p.181-187 |
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| source | Inter-Research Science Center Journals; Alma/SFX Local Collection |
| subjects | Atrophy Body mass Breeding Colonies Conspecifics Grey seals Halichoerus grypus Health risks Infections Necrosis Neonates Nucleic acids Pathogenicity Pathogens Rehabilitation Risk analysis Risk factors Seals Shedding Stranding Thymus Wildlife conservation |
| title | Widespread neonatal infection with phocid herpesvirus 1 in free-ranging and stranded grey seals Halichoerus grypus |
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