Molecular targets of biofabricated silver nanoparticles in Candida albicans
We have analyzed the expressions of genes which regulate Ras-cAMP- EFG1 and CEK1-MAPK pathways involved in yeast to hyphal form morphogenesis in Candida albicans . The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of genes involved in these pathwa...
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| Veröffentlicht in: | Journal of antibiotics 2019-08, Vol.72 (8), p.640-644 |
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| container_title | Journal of antibiotics |
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| creator | Halbandge, Shivkrupa D. Jadhav, Ashwini K. Jangid, Priyanka M. Shelar, Amruta V. Patil, Rajendra H. Karuppayil, Sankunny Mohan |
| description | We have analyzed the expressions of genes which regulate Ras-cAMP-
EFG1
and CEK1-MAPK pathways involved in yeast to hyphal form morphogenesis in
Candida albicans
. The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of genes involved in these pathways by the treatment with biofabricated silver nanoparticles. Cell elongation gene,
ECE1
, was downregulated by 5.1 fold by the treatment of silver nanoparticles. Expression of hyphal inducer gene,
TEC1
was downregulated by 6.28 fold. Negative regulators of yeast to hyphal transition,
TUP1
and
RFG1
were downregulated by 2.45 and 5.43 fold, respectively. Current study suggests that silver nanoparticles affect gene expression and may subsequently reduce virulence in
C. albicans
. Targeting genes involved in virulence may be an acceptable novel treatment strategy for pathogenic fungal infections. |
| doi_str_mv | 10.1038/s41429-019-0185-9 |
| format | Article |
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EFG1
and CEK1-MAPK pathways involved in yeast to hyphal form morphogenesis in
Candida albicans
. The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of genes involved in these pathways by the treatment with biofabricated silver nanoparticles. Cell elongation gene,
ECE1
, was downregulated by 5.1 fold by the treatment of silver nanoparticles. Expression of hyphal inducer gene,
TEC1
was downregulated by 6.28 fold. Negative regulators of yeast to hyphal transition,
TUP1
and
RFG1
were downregulated by 2.45 and 5.43 fold, respectively. Current study suggests that silver nanoparticles affect gene expression and may subsequently reduce virulence in
C. albicans
. Targeting genes involved in virulence may be an acceptable novel treatment strategy for pathogenic fungal infections.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/s41429-019-0185-9</identifier><identifier>PMID: 31019258</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/39 ; 38/77 ; 45/90 ; 631/1647/2234 ; 631/326/193/2542 ; Antifungal Agents - chemical synthesis ; Antifungal Agents - pharmacology ; Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Brief Communication ; Candida albicans - drug effects ; Candida albicans - genetics ; DNA-Binding Proteins - drug effects ; Fungal Proteins - drug effects ; Gene expression ; Gene Expression Regulation, Fungal - drug effects ; Gold ; Life Sciences ; Medicinal Chemistry ; Metal Nanoparticles ; Microbiology ; Morphogenesis ; Nanoparticles ; Nuclear Proteins - drug effects ; Organic Chemistry ; Repressor Proteins - drug effects ; Saccharomyces cerevisiae Proteins - drug effects ; Signal Transduction ; Silver ; Silver - chemistry ; Transcription Factors - drug effects ; Yeasts</subject><ispartof>Journal of antibiotics, 2019-08, Vol.72 (8), p.640-644</ispartof><rights>The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2019</rights><rights>The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-31654bdf9f2cae5e983336944a428f9385ff29b1a9366a32abe94e0d9bf659183</citedby><cites>FETCH-LOGICAL-c396t-31654bdf9f2cae5e983336944a428f9385ff29b1a9366a32abe94e0d9bf659183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31019258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Halbandge, Shivkrupa D.</creatorcontrib><creatorcontrib>Jadhav, Ashwini K.</creatorcontrib><creatorcontrib>Jangid, Priyanka M.</creatorcontrib><creatorcontrib>Shelar, Amruta V.</creatorcontrib><creatorcontrib>Patil, Rajendra H.</creatorcontrib><creatorcontrib>Karuppayil, Sankunny Mohan</creatorcontrib><title>Molecular targets of biofabricated silver nanoparticles in Candida albicans</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>We have analyzed the expressions of genes which regulate Ras-cAMP-
EFG1
and CEK1-MAPK pathways involved in yeast to hyphal form morphogenesis in
Candida albicans
. The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of genes involved in these pathways by the treatment with biofabricated silver nanoparticles. Cell elongation gene,
ECE1
, was downregulated by 5.1 fold by the treatment of silver nanoparticles. Expression of hyphal inducer gene,
TEC1
was downregulated by 6.28 fold. Negative regulators of yeast to hyphal transition,
TUP1
and
RFG1
were downregulated by 2.45 and 5.43 fold, respectively. Current study suggests that silver nanoparticles affect gene expression and may subsequently reduce virulence in
C. albicans
. Targeting genes involved in virulence may be an acceptable novel treatment strategy for pathogenic fungal infections.</description><subject>38/39</subject><subject>38/77</subject><subject>45/90</subject><subject>631/1647/2234</subject><subject>631/326/193/2542</subject><subject>Antifungal Agents - chemical synthesis</subject><subject>Antifungal Agents - pharmacology</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Brief Communication</subject><subject>Candida albicans - drug effects</subject><subject>Candida albicans - genetics</subject><subject>DNA-Binding Proteins - drug effects</subject><subject>Fungal Proteins - drug effects</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Fungal - drug effects</subject><subject>Gold</subject><subject>Life Sciences</subject><subject>Medicinal Chemistry</subject><subject>Metal Nanoparticles</subject><subject>Microbiology</subject><subject>Morphogenesis</subject><subject>Nanoparticles</subject><subject>Nuclear Proteins - drug effects</subject><subject>Organic Chemistry</subject><subject>Repressor Proteins - drug effects</subject><subject>Saccharomyces cerevisiae Proteins - drug effects</subject><subject>Signal Transduction</subject><subject>Silver</subject><subject>Silver - chemistry</subject><subject>Transcription Factors - drug effects</subject><subject>Yeasts</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1LAzEURYMoWqs_wI0E3LgZzcckTZZS_MKKG12HNzNJmZJOajIj-O9NmaoguAhvkXPvexyEzii5ooSr61TSkumC0O1TotB7aEKVogUtpd5HE0IYLZRi5Agdp7QihM_4TB2iI05zhgk1QU_Pwdt68BBxD3Fp-4SDw1UbHFSxraG3DU6t_7ARd9CFDcS-rb1NuO3wHLqmbQCDrzLZpRN04MAne7qbU_R2d_s6fygWL_eP85tFUXMt-4JTKcqqcdqxGqywWnHOpS5LKJlymivhHNMVBc2lBM6gsrq0pNGVk0JTxafocuzdxPA-2NSbdZtq6z10NgzJMEYFYUJLktGLP-gqDLHL12VKcEVnXLFM0ZGqY0gpWmc2sV1D_DSUmK1pM5o22ZrZmjY6Z853zUO1ts1P4lttBtgIpPzVLW38Xf1_6xe5tofl</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Halbandge, Shivkrupa D.</creator><creator>Jadhav, Ashwini K.</creator><creator>Jangid, Priyanka M.</creator><creator>Shelar, Amruta V.</creator><creator>Patil, Rajendra H.</creator><creator>Karuppayil, Sankunny Mohan</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20190801</creationdate><title>Molecular targets of biofabricated silver nanoparticles in Candida albicans</title><author>Halbandge, Shivkrupa D. ; Jadhav, Ashwini K. ; Jangid, Priyanka M. ; Shelar, Amruta V. ; Patil, Rajendra H. ; Karuppayil, Sankunny Mohan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-31654bdf9f2cae5e983336944a428f9385ff29b1a9366a32abe94e0d9bf659183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>38/39</topic><topic>38/77</topic><topic>45/90</topic><topic>631/1647/2234</topic><topic>631/326/193/2542</topic><topic>Antifungal Agents - chemical synthesis</topic><topic>Antifungal Agents - pharmacology</topic><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Brief Communication</topic><topic>Candida albicans - drug effects</topic><topic>Candida albicans - genetics</topic><topic>DNA-Binding Proteins - drug effects</topic><topic>Fungal Proteins - drug effects</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Fungal - drug effects</topic><topic>Gold</topic><topic>Life Sciences</topic><topic>Medicinal Chemistry</topic><topic>Metal Nanoparticles</topic><topic>Microbiology</topic><topic>Morphogenesis</topic><topic>Nanoparticles</topic><topic>Nuclear Proteins - drug effects</topic><topic>Organic Chemistry</topic><topic>Repressor Proteins - drug effects</topic><topic>Saccharomyces cerevisiae Proteins - drug effects</topic><topic>Signal Transduction</topic><topic>Silver</topic><topic>Silver - chemistry</topic><topic>Transcription Factors - drug effects</topic><topic>Yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Halbandge, Shivkrupa D.</creatorcontrib><creatorcontrib>Jadhav, Ashwini K.</creatorcontrib><creatorcontrib>Jangid, Priyanka M.</creatorcontrib><creatorcontrib>Shelar, Amruta V.</creatorcontrib><creatorcontrib>Patil, Rajendra H.</creatorcontrib><creatorcontrib>Karuppayil, Sankunny Mohan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Halbandge, Shivkrupa D.</au><au>Jadhav, Ashwini K.</au><au>Jangid, Priyanka M.</au><au>Shelar, Amruta V.</au><au>Patil, Rajendra H.</au><au>Karuppayil, Sankunny Mohan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular targets of biofabricated silver nanoparticles in Candida albicans</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>72</volume><issue>8</issue><spage>640</spage><epage>644</epage><pages>640-644</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>We have analyzed the expressions of genes which regulate Ras-cAMP-
EFG1
and CEK1-MAPK pathways involved in yeast to hyphal form morphogenesis in
Candida albicans
. The expression profile of genes associated with serum-induced morphogenesis showed reduced expressions of genes involved in these pathways by the treatment with biofabricated silver nanoparticles. Cell elongation gene,
ECE1
, was downregulated by 5.1 fold by the treatment of silver nanoparticles. Expression of hyphal inducer gene,
TEC1
was downregulated by 6.28 fold. Negative regulators of yeast to hyphal transition,
TUP1
and
RFG1
were downregulated by 2.45 and 5.43 fold, respectively. Current study suggests that silver nanoparticles affect gene expression and may subsequently reduce virulence in
C. albicans
. Targeting genes involved in virulence may be an acceptable novel treatment strategy for pathogenic fungal infections.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31019258</pmid><doi>10.1038/s41429-019-0185-9</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of antibiotics, 2019-08, Vol.72 (8), p.640-644 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 38/39 38/77 45/90 631/1647/2234 631/326/193/2542 Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Brief Communication Candida albicans - drug effects Candida albicans - genetics DNA-Binding Proteins - drug effects Fungal Proteins - drug effects Gene expression Gene Expression Regulation, Fungal - drug effects Gold Life Sciences Medicinal Chemistry Metal Nanoparticles Microbiology Morphogenesis Nanoparticles Nuclear Proteins - drug effects Organic Chemistry Repressor Proteins - drug effects Saccharomyces cerevisiae Proteins - drug effects Signal Transduction Silver Silver - chemistry Transcription Factors - drug effects Yeasts |
| title | Molecular targets of biofabricated silver nanoparticles in Candida albicans |
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