Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine

Although (+)-catharanthine is an attractive alkaloid for both clinical research and organic synthetic chemistry, only a limited number of approaches for its catalytic asymmetric synthesis exist. Herein, we describe a novel strategy for synthesizing a chiral intermediate of (+)-catharanthine via phos...

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Veröffentlicht in:	Organic letters 2019-05, Vol.21 (10), p.3750-3754
Hauptverfasser:	Kono, Masato, Harada, Shingo, Nozaki, Tomoyuki, Hashimoto, Yoshinori, Murata, Shun-ichi, Gröger, Harald, Kuroda, Yusuke, Yamada, Ken-ichi, Takasu, Kiyosei, Hamada, Yasumasa, Nemoto, Tetsuhiro
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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